Medical beta phase tricalcium phosphate/collagen cmposite material and its preparing method

A technology of β-phase tricalcium phosphate and phase tricalcium phosphate, which is applied in the field of biomedicine, can solve the problems of immune response, biological rejection, virus infection, etc., and achieve uniform distribution of components, good biocompatibility, and tight combination Effect

Inactive Publication Date: 2005-08-03
翁文剑 +7
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the source of autologous bone is limited and cannot be used for large-scale treatment; although the source of allogeneic bone is extensive, there is an immune response, and even viral infection may occur
At present, the research on bone repair materials has covered many fields including metals, ceramics, polymers and their composite materials, but these materials have their own shortcomings: some remain in the body for a long time, and are prone to biorejection effects, and some remain in the body over time. The increase of the mechanical properties decreases too fast, which cannot meet the requirements of bone repair materials

Method used

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  • Medical beta phase tricalcium phosphate/collagen cmposite material and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Dissolve 1g of collagen in 300ml of 0.01M hydrochloric acid solution and stir at the same time. After the milky white solution is formed, add 1.5g of β-phase tricalcium phosphate powder evenly into the collagen solution, then add 10ml of 1% glutaraldehyde solution, and continue stirring until White flocculent suspended matter appeared, after it was completely deposited, NaOH solution was added until the pH value was 6, the supernatant was removed after standing for 24 hours, the obtained material was put into a plastic mold with micropores on the surface, cooled in liquid nitrogen for 10 minutes, and then Dry in a freeze dryer for 72 hours, take out the material and soak it in ethanol for 24 hours × 3 times, put it in a freeze dryer again and dry it for 48 hours, take it out and sterilize it in ethylene oxide vapor for 2 hours.

Embodiment 2

[0021] Dissolve 0.4g of collagen in 100ml of 0.5M acetic acid solution, and stir at the same time. After the milky white solution, add 0.8g of β-phase tricalcium phosphate powder evenly into the collagen solution, then add 8ml of 0.5% glutaraldehyde solution, and continue stirring until White flocculent suspended matter appears, add NH after it is completely deposited 4 OH solution to a pH value of 7, after standing for 36 hours, remove the supernatant, put the obtained material into a plastic mold with micropores on the surface, cool in liquid nitrogen for 30 minutes, then put it into a freeze dryer to dry for 72 hours, put the material into ethanol after taking it out Soak it for 24 hours × 3 times, put it into the freeze dryer again to dry for 48 hours, take it out and sterilize it in ethylene oxide vapor for 3 hours. The product obtained in this example was tested by a scanning electron microscope. The internal morphology of the material is shown in Figure 1. It can be see...

Embodiment 3

[0023] Evenly add 0.5g of β-phase tricalcium phosphate powder into 400ml of collagen solution, the concentration of collagen solution is 0.5mg / ml, then add 25ml of 0.2% glutaraldehyde solution, continue to stir until white flocculent suspended matter appears, and wait until it is completely deposited Finally, add KOH solution until the pH value is 7, remove the supernatant after standing for 48 hours, put the obtained material into a plastic mold with micropores on the surface, cool it in liquid nitrogen for 60 minutes, and then put it into a freeze dryer to dry for 96 hours. Soak it in ethanol for 24h×3 times, put it into the freeze dryer again and dry it for 60h, take it out and sterilize it in ethylene oxide vapor for 1h.

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Abstract

The medical composite beta-tricalcium phosphate/collagen material consists of nano level beta-tricalcium phosphate in 50-67 wt% and collagen 33-50 wt%. Through in-situ complexing of collagen and beta-tricalcium phosphate, nanometer level beta-tricalcium phosphate powder is deposited on collagen substrate, and under the action of glutaraldehyde, the composite material has raised mechanical strength. The composite beta-tricalcium phosphate/collagen material of the present invention has homogeneous components, close combination, excellent biocompatibility, proper pore size and other features, and is suitable for use as the medical bone repairing material.

Description

technical field [0001] The invention relates to a medical β-phase tricalcium phosphate / collagen composite material and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] Accidents or diseases cause damage or loss of human bones, teeth and other hard tissues, thus forming a huge market for medical repair materials. Typically, autograft and allograft are used as options for the treatment of bone defects. However, the source of autologous bone is limited and cannot be used for a wide range of treatments; although allogeneic bone comes from a wide range of sources, there is an immune response, and even viral infection may occur. At present, the research on bone repair materials has covered many fields including metals, ceramics, polymers and their composite materials, but these materials have their own shortcomings: some remain in the body for a long time and are prone to biorejection, and some remain in the body over ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44
Inventor 翁文剑邹超邓旭亮罗永明胡晓阳孙志辉李洪张明志
Owner 翁文剑
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