High-strength magnetic calcium-phosphate-based bone cement and preparation method thereof

A calcium phosphate, high-strength technology, applied in medical science, prosthesis, etc., can solve the problems of high bone cement preparation process requirements, prone to danger, low mechanical strength, etc., and achieve good injectability, safe operation, and easy preparation The effect of low temperature

Inactive Publication Date: 2013-04-24
HENAN UNIV OF SCI & TECH
View PDF4 Cites 13 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problems that the mechanical strength of the existing calcium phosphate-based bone cement is relatively low, and the bone cement prepared by the ion modification method has high requirements for the preparation process, is prone to danger, and has high energy consumption. The present invention provides a high-strength magnetic phosphoric acid Calcium-based bone cement and its preparation method

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • High-strength magnetic calcium-phosphate-based bone cement and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0031] The preparation method of the high-strength magnetic calcium phosphate-based bone cement comprises the following steps:

[0032] 1) Preparation of manganese zinc ferrite

[0033] 1) According to Mn 0.4 Zn 0.6 Fe 2 o 4 The stoichiometric ratio weighs FeCl 3 ·6H 2 O, ZnCl 2 and MnCl 2 4H 2 O is made into a mixture, and ultrapure water is added to make a solution with a total concentration of metal ions of 0.3mol / L, and the reaction is carried out at a constant temperature of 90°C for 4 hours;

[0034] During the reaction, under the condition of strong stirring, the NaOH solution with a concentration of 1mol / L was added dropwise to the solution to control the pH value of the reaction solution to be 9.5-10.5;

[0035] The strong stirring here is mainly to dissipate the heat generated by the reaction, and stir at a stirring speed of 3000rpm in actual operation;

[0036] 2) Wash the reaction solution and the generated precipitate in step 1), centrifuge, and vacu...

Embodiment 1

[0053] A preparation method of high-strength magnetic calcium phosphate-based bone cement, comprising the following steps:

[0054] 1) Preparation of manganese zinc ferrite

[0055] 1) According to Mn 0.4 Zn 0.6 Fe 2 o 4 The stoichiometric ratio weighs FeCl 3 ·6H 2 O, ZnCl 2 and MnCl 2 4H 2 O is made into a mixture, and ultrapure water is added to make a solution with a total concentration of metal ions of 0.3mol / L, and the reaction is carried out at a constant temperature of 90°C for 4 hours;

[0056] During the reaction, under the condition of strong stirring, the NaOH solution with a concentration of 1mol / L was added dropwise to the solution to control the pH value of the reaction solution to be 9.5-10.5;

[0057] 2) Wash the reaction solution and the generated precipitate in step 1), centrifuge, and vacuum-dry at 60°C to obtain the manganese-zinc-ferrite precursor, which is set aside;

[0058] 3) Calcining the manganese-zinc-ferrite precursor obtained in step...

Embodiment 2

[0068] A preparation method of high-strength magnetic calcium phosphate-based bone cement, comprising the following steps:

[0069] 1) Preparation of manganese zinc ferrite, as in Example 1;

[0070] 2) Preparation of solid phase mixture

[0071] Weigh β-tricalcium phosphate and Ca(H 2 PO 4 ) 2 ·H 2 O powder is put into mortar and grinds 15min, makes mixed powder, for subsequent use;

[0072] Take the modified manganese zinc ferrite powder prepared in step 1) and the mixed powder prepared in step 2) according to the weight ratio of 1: 6, mix them in a mortar and grind for 15 minutes, and mix them evenly to obtain a solid phase mixture ,spare;

[0073] c) Liquid phase preparation

[0074] Preparation concentration is that the citric acid solution of 0.8mol / L is standby as liquid phase;

[0075] 4) Solid phase mixture and liquid phase reconciliation

[0076] Add the citric acid solution in step 3) to the solid phase mixture prepared in step 2) according to the rati...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
compressive strengthaaaaaaaaaa
compressive strengthaaaaaaaaaa
compressive strengthaaaaaaaaaa
Login to view more

Abstract

The invention relates to high-strength magnetic calcium-phosphate-based bone cement which is obtained by blending a solid-phase mixed material and a liquid phase before use. The ratio of the solid-phase mixed material to the liquid phase when blending is that every 2.8-3.2g of the solid-phase mixed material requires 1mL of liquid phase. The liquid phase is a citric acid solution with a concentration of 0-0.8mol / L. The solid-phase mixed material is composed of the raw materials of beta-tricalcium phosphate, Ca(H2PO4)2.H2O, and Mn-Zn ferrite with a chemical composition of Mn0.4Zn0.6Fe2O4. The molar ratio of beta-tricalcium phosphate to Ca(H2PO4)2.H2O is 1:0.8-1.2. The weight ratio of Mn-Zn ferrite to the mixture of beta-tricalcium phosphate and Ca(H2PO4)2.H2O is 1:4-6. According to the invention, beta-tricalcium phosphate, Ca(H2PO4)2.H2O, and modified Mn-Zn ferrite with the chemical composition of Mn0.4Zn0.6Fe2O4 are adopted as solid-phase raw materials. With the three substances, preparation temperature is low, energy consumption is low, quenching is not needed, and operation is safe. The compressive strength of the bone cement can reach 112MPa, which is greatly higher than that of existing calcium-phosphate-based bone cement. The bone cement has good injectable performance, anti-collapsing performance, and low cytotoxicity.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a high-strength magnetic calcium phosphate-based bone cement and a preparation method thereof. Background technique [0002] Calcium phosphate-based bone cement is usually prepared by blending a solid phase and a liquid phase. The solid phase is a mixture of one or more phosphates, and the liquid phase is usually water or a water-based solution. Calcium phosphate-based bone cement has good biocompatibility, can be clinically shaped arbitrarily, and is easy to operate, and it can be processed into a slurry form and directly injected into bone defects and solidified in situ to achieve minimally invasive, so it is clinically favored by surgeons. welcome and widely used. [0003] Bone cement needs to replace bone tissue to play a load-bearing role after implanted in the body, so the mechanical properties are a very important performance of bone cement. Although calcium phosphate-based bone ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622A61L27/10
Inventor 李光大冯书营赵三团李萍乔晓岚谢蟪旭何华伟
Owner HENAN UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap