Bone repairing biological ceramic material based on 3D printing and preparation method thereof

A bioceramic material, 3D printing technology, applied in the field of biomedical materials, can solve problems such as difficulty in mass construction, and achieve the effect of improving biocompatibility and good mechanical properties

Active Publication Date: 2016-07-20
SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional scaffold materials and preparation techniques are difficult to construct complex bone repair materials of various shapes in large quantities to meet the needs of clinical personalized repair

Method used

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  • Bone repairing biological ceramic material based on 3D printing and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 1.26g PLA, put it into a beaker, add a stirrer, inhale CHCl3 (analytical pure, Hengyang Kaixin Chemical Reagent Co., Ltd.) with a plastic dropper, dropwise add it to the beaker, drop 7.13g to stop, and use a parafilm Seal the mouth of the beaker, then place it on a stirrer and stir until the PLA is completely dissolved, and adjust the rotation speed so that the solution has no bubbles, and prepare a 15wt% transparent solution A. Then weigh 1.47g β-TCP and nano-HA respectively, add them to solution A, stir for 1h until uniform and stable, and obtain slurry B, fill slurry B into the pre-prepared needle tube (EFD), and seal it with parafilm The rear end and the front end of the needle tube were left to age for 24 hours to obtain slurry C. The high-precision air-floating automatic three-dimensional motion platform ABL10150 (Aerotech, U.S.A.) with pre-adjusted three-dimensional fine direct writing movement, the control intelligent extrusion system EFDUltraTM2400, the wo...

Embodiment 2

[0029] Take 1.43g PLA, put it into a beaker, add a stirring bar, inhale CHCl3 drop by drop into the beaker with a rubber dropper, stop dropping 8.10g, seal the mouth of the beaker with a parafilm, and then put it on the stirrer Stir until the PLA is completely dissolved, and adjust the rotation speed so that the solution has no bubbles, and prepare a 15wt% transparent solution A. Then weigh 2.86g of β-TCP and nano-HA respectively, add them to solution A, stir for 1h until uniform and stable, and obtain slurry B, fill slurry B into a pre-prepared needle tube (EFD), and seal it with a parafilm The rear end and the front end of the needle tube were left to age for 24 hours to obtain slurry C. The high-precision air-floating automatic three-dimensional motion platform ABL10150 (Aerotech, U.S.A.) with pre-adjusted three-dimensional fine direct writing movement, the control intelligent extrusion system EFDUltraTM2400, the working input air pressure is 480KPa-580KPa, and the air pres...

Embodiment 3

[0033] Take 1g PLA, put it into a beaker, add a stirring bar, and suck CHCl with a plastic dropper 3 Add drop by drop into the beaker, stop dropping 9g, seal the mouth of the beaker with a parafilm, then put it on the stirrer and stir until the PLA is completely dissolved, and adjust the speed so that the solution has no bubbles, and prepare a 10wt% transparent Solution A. Then weigh 4.5g of β-TCP and nano-HA respectively, add them to solution A, stir for 1h until uniform and stable, and obtain slurry B, fill slurry B into the pre-prepared needle tube (EFD), and seal it with parafilm The rear end and the front end of the needle tube were left to age for 24 hours to obtain slurry C. The high-precision air-floating automatic three-dimensional motion platform ABL10150 (Aerotech, U.S.A.) with pre-adjusted three-dimensional fine direct writing movement, the control intelligent extrusion system EFDUltraTM2400, the working input air pressure is 480KPa-580KPa, and the air pressure af...

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Abstract

A bone repairing biological ceramic material based on 3D printing is prepared from beta-tricalcium phosphate, hydroxyapatite and polylactic acid with the molecular weight being 100,000-120,000 and the viscosity being 0.79 dL / g-0.84 dL / g, and is of a three-dimensional grid structure with the porosity being 70%-90%, and the line diameter forming a grid is 100 micrometers to 300 micrometers. A preparation method comprises the steps that polylactic acid is dissolved in chloroform to prepare a solution with the mass concentration being 15-20%; beta-tricalcium phosphate and hydroxyapatite are added into the solution, and the mixture is stirred evenly and stably so that composite pulp can be obtained; the composite pulp is added into a 3D printing device to be printed, a precursor of the printed biological ceramic material is vacuumized so that chloroform can be fully volatized, and the product is obtained. The ceramic material is adjustable in degradation rate and good in mechanical performance and biocompatibility, can adapt to osteocyte and chondrocyte co-culture and composition of growth factors or micro-molecule polypeptides and can be used for simultaneous repairing of bones and cartilages.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a 3D printing-based bioceramic material used for repairing osteochondral defects, and to a preparation method thereof. Background technique [0002] Every year in my country, traffic accidents and production safety accidents cause many traumatic fractures, plus bone tumors, avascular necrosis of the femoral head and other orthopedic diseases, resulting in more than 3 million cases of bone defects. Clinically, due to the limited source of autologous bone, immune rejection of allogeneic bone and xenograft bone, and the potential risk of pathogen transmission, there is an urgent need to develop bone tissue repair materials for the treatment of bone defects. Traditional scaffold materials and preparation techniques are difficult to construct complex bone repair materials of various shapes in large quantities to meet the needs of clinical personalized repair. Scaffold materials fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/12A61L27/56A61L27/50
CPCA61L27/12A61L27/18A61L27/50A61L27/56A61L2430/02A61L2430/06C08L67/04
Inventor 李勃许国军朱朋飞周济
Owner SHENZHEN GRADUATE SCHOOL TSINGHUA UNIV
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