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Medicinal sustained-release hydrogel as well as preparation method and application thereof

A hydrogel and drug technology, applied in the field of drug sustained-release hydrogel and its preparation, can solve the problems such as the research on the release rate and time of negative ions, the lack of application carrier in the drug sustained-release system, and the inability to achieve skin repair, so as to protect the drug. Bioactive, good elasticity, mild effects

Active Publication Date: 2013-12-25
薛巍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the drug sustained-release system prepared by this technology lacks the application carrier
[0008] Chinese Patent Application No. 200810001455.X discloses a polyvinyl alcohol hydrogel that releases negative ions and its preparation. By changing the percentage of negative ions, the negative ion concentration of the product is changed. However, the release rate and time of negative ions have not been studied, and the gel The use of rare earth additives in glue may cause certain cytotoxicity and affect the skin
This product also can't reach the purposes of skin repairs such as burns to be applied by the present invention, scald

Method used

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  • Medicinal sustained-release hydrogel as well as preparation method and application thereof
  • Medicinal sustained-release hydrogel as well as preparation method and application thereof
  • Medicinal sustained-release hydrogel as well as preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0036] Experimental materials: sodium alginate (the viscosity of 2% aqueous solution at 25°C is 250cps), Sigma Company; polyvinyl alcohol (alcoholysis degree: 99.8~100%), Aladdin Company; carboxymethyl chitosan (deacetylation degree : ≥90, carboxylation degree: ≥80%), Guangzhou Feibo Biotechnology Co., Ltd.; heparin sodium (>170 units / mg), Bailingwei Company; bovine serum albumin (BSA), Genview Company; basic fibroblast growth Factor (bFGF), Biomedical Base of Jinan University.

[0037]High-voltage DC power supply (DW-P503-4ACCD), Tianjin Sanchuan Company; micro syringe pump (LSP01-1A), Baoding Lange Company; digital display air bath constant temperature oscillator (CHA-S), Jiangsu Jintan Co., Ltd.; syringe ( 2.5ml), Zhejiang Jinghuan Medical Supplies Co., Ltd.; polystyrene orifice plate (6, 24 holes), Nice Biotechnology Co., Ltd.

[0038] Experimental content: Calcium alginate microspheres were prepared by high-voltage electrostatic droplet method, with 10mg / ml BSA and 2wt% ...

Embodiment 2

[0046] Calcium alginate microspheres were prepared by high-voltage electrostatic droplet method, using 1.17 μg / ml basic fibroblast growth factor (bFGF)-containing 1wt% heparin aqueous solution and 2wt% sodium alginate aqueous solution as raw materials, 3% (w / v) CaCl 2 The aqueous solution is used as the receiver, the inner diameter of the needle is 200μm, and the needle tip is kept in contact with CaCl 2 The liquid surface distance of the solution is 20 cm, and the electric field voltage is 10 kV. Cured for 10 minutes, washed three times with deionized water. Use filter paper to filter out the moisture on the surface of the microspheres, weigh 50 mg of calcium alginate microspheres and add them to two uniformly mixed hydrogel matrices, which contain 2% carboxymethyl chitosan and 10% polyvinyl alcohol solution, its volume is 2:4, vortex for a few seconds to make it evenly dispersed. The hydrogel containing calcium alginate microspheres was frozen at -20°C for 20 h, and then...

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Abstract

The invention discloses medicinal sustained-release hydrogel as well as a preparation method and an application thereof. Monodisperse medicament-containing calcium alginate microspheres are prepared by adopting a high-pressure electrostatic sessile drop method, to realize direct encapsulation of growth factors and keep the activity of medicaments; and the medicament-carrying calcium alginate microspheres are put into the netlike structure of the hydrogel to realize sustained release of the medicaments. The matrix of the hydrogel contains carboxymethyl chitosan and polyvinyl alcohol, the volume ratio of the carboxymethyl chitosan solution to the polyvinyl alcohol solution is n: (6-n), 0<n<=4, and the release rate of the medicaments is controlled through different volume ratios.

Description

technical field [0001] The invention belongs to the technical field of macromolecules and the technical field of drug sustained release. In particular, it relates to a drug sustained-release hydrogel and a preparation method thereof. Background technique [0002] Growth factors have the function of promoting the healing of wounds and ulcers, and can be used for the treatment of wounds, burns, ulcers and other diseases. However, FGF-2 is mostly administered by water or spray, which leads to high production costs and is easily degraded by wound proteases. There are many problems such as frequent dressing changes, short residence time on the wound surface, no protective effect on the wound surface, and inconvenient use, which are greatly restricted in clinical use. In order to improve its bioavailability, the development of new formulations of FGF-2 with sustained release has broad prospects, which can improve the wound healing speed and quality of such patients, thereby impro...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/08C08L29/04C08L5/04B01J13/02A61L15/28A61L15/24A61L15/42A61L15/44A61K47/36A61K47/32A61K9/06
Inventor 薛巍刘权左琴华何留民黄跃新
Owner 薛巍
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