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Preparation method of cationic hydrogel

A technology of cationic hydrogel and cationic starch, applied in the field of pharmaceutical dosage forms, can solve problems such as being unsuitable for large-scale production and application, and achieve the effects of cheap raw materials, easy availability of raw materials, and simple preparation process

Pending Publication Date: 2020-04-24
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, there are various preparation methods and types of hydrogels, and most of the raw materials are artificially synthesized, which is not suitable for large-scale production and application.

Method used

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  • Preparation method of cationic hydrogel
  • Preparation method of cationic hydrogel
  • Preparation method of cationic hydrogel

Examples

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Effect test

Embodiment 1

[0027] A kind of preparation of cationic hydrogel, its preparation method comprises the following steps:

[0028] (1) Mix 10g of polyvinyl alcohol and 2g of cationic starch and dissolve in 100mL of water, stir and heat at 90°C for 2h, mix the polymer completely, and dissolve in water.

[0029] (2) The polymer aqueous solution was poured into the mold, frozen at -25°C for 16 hours, thawed at 25°C for 8 hours, and repeated once to obtain a hydrogel containing cations.

Embodiment 2

[0031] A kind of preparation of cationic hydrogel, its preparation method comprises the following steps:

[0032] (1) Mix 10g of polyvinyl alcohol and 2g of cationic starch and dissolve in 100mL of water, stir and heat at 90°C for 2h, mix the polymer completely, and dissolve in water.

[0033] (2) The polymer aqueous solution was poured into the mold, frozen at -25°C for 20 hours, thawed at 25°C for 4 hours, and cycled 3 times to obtain a hydrogel containing cations.

Embodiment 3

[0035] A kind of preparation of cationic hydrogel, its preparation method comprises the following steps:

[0036] (1) Mix 10g of polyvinyl alcohol and 2g of cationic starch and dissolve in 100mL of water, stir and heat at 90°C for 2h, mix the polymer completely, and dissolve in water.

[0037] (2) The polymer aqueous solution was poured into the mold, frozen at -25°C for 22 hours, thawed at 25°C for 2 hours, and cycled 5 times to obtain a hydrogel containing cations.

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Abstract

The invention discloses a preparation method of a cationic hydrogel. The method comprises the following steps: heating a mixture of polyvinyl alcohol and cationic starch at 90 DEG C for 2-4 h to achieve complete and uniformly mixing, dissolving the obtained mixture in water, and cooling to room temperature to obtain an aqueous polymer solution, wherein the mass ratio of the polyvinyl alcohol to the cationic starch is (1-5):1, and the total mass of the polyvinyl alcohol and the cationic starch is 12% of the total mass of the aqueous polymer solution; freezing the aqueous polymer solution at -25DEG C for 16-20 h, unfreezing at 25 DEG C for 4-8 h, and repeating for 1-5 times to obtain the hydrogel containing cations. The preparation process is simple, the raw materials are cheap and easy toobtain, the polyvinyl alcohol and the cationic starch are used as the raw materials, a cross-linking agent is not introduced, and the physical cross-linked hydrogel can be prepared through a refrigeration cycle method. The hydrogel adhesive tape has positive charges, the slow release effect of a drug is achieved through anion and cation combination in different pH environments, the advantages of the polyvinyl alcohol and cationic starch are combined, and the cationic hydrogel can be widely applied to the field of drug carriers.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical dosage forms, and specifically relates to a preparation method of cationic hydrogel. Background technique [0002] Hydrogel is a hydrophilic polymer material with a three-dimensional network structure. It can absorb a large amount of water, but because of its inherent three-dimensional network structure, it has the characteristics of water retention and no bursting after swelling. [0003] Generally speaking, hydrogels are classified from four aspects: raw materials are divided into natural polymer hydrogels and synthetic polymer hydrogels; cross-linking methods are divided into physical cross-linked hydrogels and chemical hydrogels. Cross-linked hydrogel; in terms of shape and size, it can be divided into macroscopic hydrogel and microscopic hydrogel; in terms of response to external stimuli, it can be divided into traditional hydrogel and responsive hydrogel. Hydrogels have good water r...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L89/00C08L3/08A61K9/06A61K47/32A61K47/36
CPCC08J3/075C08J3/24A61K9/06A61K47/32A61K47/36C08J2329/04C08J2403/08
Inventor 王培鑫王纯洁翟晚娜金志敏
Owner ZHEJIANG UNIV OF TECH
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