Medical antibacterial hydrogel dressing preparation method

An antibacterial water and gel technology, applied in the fields of medical science, rayon manufacturing, fiber chemical characteristics, etc., can solve the problems of mechanical properties and antibacterial ability need to be further strengthened, so as to promote fusion and dispersion, improve mechanical properties, and improve antibacterial properties. effect of effect

Active Publication Date: 2018-10-19
广东安道医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as the requirements for medical hydrogel dressings are getting higher and higher, their mechanical properties and antibacterial capabilities need to be further strengthened.

Method used

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  • Medical antibacterial hydrogel dressing preparation method

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Embodiment 1

[0019] A method for preparing a medical antibacterial hydrogel dressing, comprising the following steps:

[0020] (1) Add 20 parts by weight of oxidized sodium alginate into distilled water, stir and dissolve for 20 minutes, prepare a 10% oxidized sodium alginate solution, store it in the dark, and set aside;

[0021] (2) Place 40 parts of carboxymethyl chitosan in a vacuum drying oven, dry at 40°C for 5 hours, then add the dried carboxymethyl chitosan to distilled water 20 times its volume, and heat up to 40°C , stirring and dissolving at a speed of 400rpm;

[0022] (3) Add the solution obtained in step (1) to the solution obtained in step (2), continue to stir at 40°C and 400 rpm for 10 minutes, then add 10 parts of graphene oxide-carboxymethyl chitosan spinning fibers, and increase the speed to Stir at 800rpm for 5min, keep the temperature at 40°C, and let stand for 1h to form a gel.

[0023] Further, the preparation method of the graphene oxide-carboxymethyl chitosan spi...

Embodiment （2）

[0031] A method for preparing a medical antibacterial hydrogel dressing, comprising the following steps:

[0032] (1) Add 25 parts by weight of oxidized sodium alginate into distilled water, stir and dissolve for 30 minutes, prepare a 15% oxidized sodium alginate solution, store it in the dark, and set aside;

[0033] (2) Put 45 parts of carboxymethyl chitosan in a vacuum drying oven, dry at 50°C for 7 hours, then add the dried carboxymethyl chitosan to distilled water 22 times its volume, and heat up to 45°C , stirring and dissolving at a speed of 500rpm;

[0034] (3) Add the solution obtained in step (1) to the solution obtained in step (2), continue to stir at 45°C and 500 rpm for 20 minutes, then add 15 parts of graphene oxide-carboxymethyl chitosan spinning fibers, and increase the speed to Stir at 900 rpm for 7 minutes, keep the temperature at 42°C, and let stand for 2 hours to form a gel.

[0035] Further, the preparation method of the graphene oxide-carboxymethyl chi...

Embodiment 3

[0043] A method for preparing a medical antibacterial hydrogel dressing, comprising the following steps:

[0044] (1) Add 30 parts by weight of oxidized sodium alginate into distilled water, stir and dissolve for 40 minutes, prepare a 20% oxidized sodium alginate solution, store it in the dark, and set aside;

[0045] (2) Place 50 parts of carboxymethyl chitosan in a vacuum drying oven, dry at 60°C for 10 hours, then add the dried carboxymethyl chitosan to distilled water 25 times its volume, and heat up to 50°C , stirring and dissolving at a speed of 600rpm;

[0046] (3) Add the solution obtained in step (1) to the solution obtained in step (2), continue to stir at 50°C and 600 rpm for 30 minutes, then add 20 parts of graphene oxide-carboxymethyl chitosan spinning fibers, and increase the speed to Stir at 1000rpm for 10min, keep the temperature at 45°C, and let stand for 3h to form a gel.

[0047] Further, the preparation method of the graphene oxide-carboxymethyl chitosan sp...

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Abstract

The invention discloses a medical antibacterial hydrogel dressing preparation method which comprises the following steps: firstly, utilizing graphene oxide to modify carboxymethyl chitosan and wrapping the graphene oxide with the carboxymethyl chitosan; then spinning, freeze drying and smashing to form fibers; then reacting with oxidized sodium alginate and the carboxymethyl chitosan to form hydrogel dressing. The medical antibacterial hydrogel dressing has an excellent antibacterial effect; furthermore, the mechanical property of the hydrogel dressing is remarkably improved; the hydrogel dressing has good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of medical dressings, in particular to a method for preparing a medical antibacterial hydrogel dressing. Background technique [0002] Hydrogel is a kind of insoluble gel polymer with three-dimensional hydrophilic network cross-linked by water-soluble polymers. At present, hydrogel has been widely studied and applied in the field of medical dressings. The high water content of the hydrogel can promote the growth of granulation tissue and epithelium in a humid environment, and its elastic properties can bring convenience to wound treatment, making the wound heal without any damage. At the same time, the hydrogel also has the effect of soothing and cooling the surface skin. Curative effect, can reduce wound temperature, suitable for chronic wounds, necrotic wounds, pressure ulcers and burns, etc. On the other hand, the hydrogel also has the effect of sustained drug release, which mainly makes use of physical ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00D01F1/10D01F9/00
CPCA61L26/0004A61L26/0023A61L26/0066A61L26/008A61L2300/10A61L2300/404A61L2300/602D01F1/10D01F9/00C08L5/08C08L5/04
Inventor 饶建军
Owner 广东安道医疗器械有限公司
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