31results about How to "Prolong the duration of action of the drug" patented technology

The present invention relates to medicine preparation of arteannuin and dihydroartemisine for resisting vascularization and its use. The preparation has arteannuin or dihydroartemisine as main component and is prepared into microball injection. It is used in treating tumor vascularization and other vascularization relevant diseases and may be also used in chemotherapy of tumor. Its slow release and absorption in the administrated part results in the acting period of the medicine. The present invention is based on vascularization theory, describes the function and mechanism of single Chinese medicinal component, is one important direction for developing Chinese medicine theory and provides basis for developing the new use of artemisine medicine.

The invention belongs to the technical field of biological medicines and nanomedicine and relates to an RGD (Arginine-Glycine-Aspartic Acid) peptide modified double-layer medicine carrying cation nanometer particle. The inner core of the nanometer particle disclosed by the invention is a polylactic acid-hydroxyacetic acid PLGA medicine carrying layer; the outer layer of the nanometer particle is an RGD modified cation polymer layer which is carried with a medicine sensitizer. The nanometer particle can penetrate through blood brain barrier through receptor mediation and electrostatic adsorption action, can be gathered at the brain tumor tissue after entering the brain, can deeply penetrate through the solid parts of the tumor under the RGD mediation to specially combine with tumor new vessel endothelial cells and tumor cells and can enter the cells through endocytosis. The sensitizer dispersed at the outer layer is firstly released to play a role of reversing tumor drug resistance and the medicine dispersed at the inner layer is slowly released, so that the efficient, lasting and safe anti-tumor curative effect of the effect is brought into play.

The invention relates to a long-acting cefquinome sulfate injection. The injection is prepared by a method in the following steps: adding cefquinome sulfate into an ethanol solution containing ethyecellulose and hydroxy propyl cellulose; filtering, sterilizing and performing spray-drying to obtain a cefquinome sulfate carrier; adding a suspending agent, a dispersing agent and a stabilizing agent into partial injection solvent, dissolving at 100 DEG C, and adding an injection solvent to the whole amount, and performing dry heat sterilization at 150 DEG C for 1 hour; cooling the dispersion liquid to room temperature, adding the cefquinome sulfate carrier into the dispersion liquid, and uniformly stirring; passing through a high-speed cutting dispersion machine to prepare the long-acting cefquinome sulfate injection. The prepared suspension injection is uniform in granularity, good in fluidity, slow in settlement, good in redispersion property, wall adhesion prevention of liquid medicine, good needle cleaning performance, no discoloration after long-term storage and stable chemical property. After the preparation is injected in a pig in an intramuscular manner, the preparation is slowly released, long in elimination half life and smooth in plasma concentration, can be used for prolonging the effective action duration of the medicine in the body and reducing the number of administration times, and is convenient to use.

The jelly contains zedoary oil and borneol in the ratio of 1.0933, has pH value of 3-7, and features the functions of treating mycotic vaginitis, senile vaginitis, cervical erosion and other women's diseases.

The invention provides an implantable dosage for huperzine-a and the derivatives or the salt, which comprises essentially huperzine-a, the derivatives or the salt, and macromolecule accessories. The invention is characterized in that the solid implantable dosage of the huperzine-a and the derivatives or the salt can be conveyed into the body by way of implant surgery; or the solution or gel of the implantable dosage of the huperzine-a and the derivatives or the salt are injected into the body to form semi-solid or gel implanted object. When used to cure senile diseases such as alzheimer disease and vascular dementia, The implantable dosage has the advantages of lengthened drug treating time, reduced times for drug taking, enhanced bioavailability of the huperzine-a and the derivatives or the salt, decreased poison and side effects of the drug, and greatly enhanced drug compliance of the patients.

The invention relates to a cinnamic acid compound of which the structure is as shown in the formula (I), wherein R1, R2, R3, R4 and R5 are separately selected from a group consisting of hydrogen, hydroxyl and methoxy, and R6 is a linear chain alkyl group with 3-6 carbon atoms. The invention further relates to a medical composition which comprises a styrene acid compound, organic carboxylic acid, a pH-regulating agent and one or more optional auxiliary materials which are pharmaceutically acceptable, and the pH value of the medical composition is 6-8. The styrene acid compound accounts for 0.05-1.00wt% of the medical composition, and the organic carboxylic acid accounts for 0.01-0.50wt% of the medical composition. The invention further relates to the application of the cinnamic acid compound and the medical composition for preparing medicines for preventing and/or treating eye diseases caused by diabetes.

The present invention discloses a biodegradation type long-acting contraception microsphere and a preparation method and an application thereof, belonging to a pharmacy technology field. The biodegradation type long-acting contraception microsphere is taken a biodegradable manpower synthetic polymer as a carrier and a Nestorone as a basic remedy, wherein a weight shares of the carrier is from 100 to 140 shares, the weight share of the basic remedy is from 2 to 10 shares. The preparation method includes dissolving the basic remedy and the carrier in an organic solvent to obtain a solution containing the basic remedy and the carrier, adding the solution containing the basic remedy and the carrier into a stabiliser water solution of 10-20 shares by weight as well as agitating, agitating to emulsify thoroughly, remixing to volatilize the organic solvent, solidifying to obtain a microsphere. The invention also provides an application of the microsphere, that is the microsphere is prepared into an injecting heeling-in agent by a preparation method of a conventional medicinal preparation. The long-acting Nestorone microsphere of the invention has an integral modality, the microsphere dimension is from 10 to 50 [Mu]m, the diameter is distributed well, and a vitro release time is from 1 to 12 weeks.

The invention provides a medicinal composition for treating allergic rhinitis, which is a medicament prepared from the following traditional Chinese medicines in part by weight: 14 to 26 parts of paniculate swallowwort root, 3.15 to 5.85 parts of cicada slough, 0.021 to 0.039 part of borneol and 0.21 to 0.39 part of bezoar. The invention also provides a preparation method and application of the medicinal composition. The medicinal composition has the effects of expelling wind, reducing heat, and causing resuscitation and refreshing nose and has an obvious clinical treatment effect. Efficacy trials show that drops of the medicinal composition relieves allergic reaction of nasal meatus by reducing AR guinea pig blood LTE4, IgE concentration, inhibiting the release of inflammatory mediator and reducing the aggregation of inflammatory cells on mucous membrane of nose.

The invention discloses a huperzine A acupoint sustained-release gel patch for treating senile dementia and a preparation method thereof. When in use, the sustained-release gel patch is applied to theDazhui acupoint of the governor meridian of a patient, huperzine A is absorbed by the skin of the Dazhui acupoint and distributively enters the brain tissues to play a role in brain-targeted treatment, and entry of drugs into the blood circulation system is reduced, so that adverse reactions are avoided; and meanwhile, the patch belongs to a novel hydrogel drug delivery system, a preparation matrix is soft, comfortable and high in skin affinity, the patch is safe, non-irritating and non-allergic to the skin, and the drug action time is long, so that the drug delivery frequency is reduced. Therefore, the patch solves the problem of poor curative effect or adverse reactions caused by the fact that AD patients often forget to take medicines or take excessive medicines or take wrong medicinesdue to weakened memory and reduced intelligence, provides a novel medicinal preparation which is reliable in curative effect, convenient to use, safe and non-toxic for the treatment of the AD patients, and has important clinical values and wide market prospects.

The invention discloses lipopeptide based on melittin and a preparation method and application thereof, and belongs to the field of biological medicine. The lipopeptide is obtained by coupling C10-18 fatty acid at the N end of melittin and performing amidation modification on the C end of melittin. Experiments show that compared with parent melittin, the lipopeptide has a better inhibition effect on gram-positive bacteria and gram-negative bacteria, and has lower hemolytic activity. In an in-vitro stability test, the lipopeptide shows better stability in pepsin, trypsin and serum, is the lipopeptide with great application value, can be used for preparing a novel anti-bacterial infection medicine and the like, and has a very wide application prospect.

The invention provides a method for administering TRAIL-like protein to continuously inhibit tumor cell growth, which is a method for intermittent, repeated and full-course drug exposure. By increasing the interval of administration, increasing the exposure time of tumor cells in the whole course of treatment, the effect of the drug in the entire course of treatment is not attenuated, thereby continuing to inhibit tumor growth.

The invention discloses a combined medicine for treating rhinitis by stuffing the medicine in a nose. The combined medicine comprises the following medicine combination: base medicine paste, rhinitispowder I, rhinitis powder II, soothing tarpaulin, a nasal spray and oral pills. The invention also discloses the combined medicine for treating rhinitis by stuffing the medicine in the nose and a preparation method of the combined medicine. The preparation method specifically comprises the following steps: mixing and crushing fried cocklebur fruits, herba centipedae, fructus gleditsiae, artificialmusk, yellow croaker ear-stone and radix angelicae into powder, pouring vaseline molten by heating, uniformly mixing the vaseline, and bagging the obtained mixture for later use after cooling; and mixing and stirring the fried cocklebur fruits, the herba centipedae, the fructus gleditsiae, borneol and menthol uniformly, crushing the mixture into powder, and bottling the powder for later use. By use of the method of stuffing the medicine in the nose, the medicine makes direct contact with a lesion part, the the method has the characteristics of accurate medicine application part, long local medicine acting time, safety, rapidness, effectiveness, simplicity and convenience, the spray and the pills are matched in rhinitis treatment for assistance, both symptoms and root causes are treated, and the treatment effect is improved more rapidly and comprehensively.

The invention relates to a wild chrysanthemum total flavonoid bio-adhesive double-layer patch for treating oral ulcer, which can effectively solve the therapeutic medication problem of oral ulcer; the patch is prepared by combining an adhesive layer with a protective layer, wherein the adhesive layer is prepared by 5-15 g of wild chrysanthemum total flavonoids, 5-15 g of carbomer 934P, 10-30 g ofhydroxy propyl cellulose, and 1-3 g of lactose, and the protective layer is prepared by 4-12 g of ethyl cellulose; the preparation method comprises the following steps: adding lactose into wild chrysanthemum total flavonoids, well mixing, adding carbomer 934P and hydroxy propyl cellulose, well mixing, sieving, pressing into a sheet-like adhesive layer, pressing ethyl cellulose on the adhesive layer to form the composite double-layer patch; the invention prolongs the action time of the drugs, greatly improves the curative effect, shortens the treatment course, reduces the administration frequency, increases patient compliance; the patch covers and adheres to a ulcer surface for longer time than pellicles, has protection effect on wound, and can reduce patient pain.

The invention discloses a drug slow-release device which comprises a closed main body container. The main body container is provided with a liquid inlet and liquid outlets of a plurality of emulsion droplet shaped protrusions. In this way, the drug slow-release device is simple in structure, convenient to operate and environmentally friendly and can achieve long acting in use. Drug release can becontrollable through the drug slow-release device, the release time can be prolonged, drug release can be stable, the acting time is long, the use amount of a drug is decreased, and the use efficiencyof the drug is improved.

The invention relates to a medicine preparation, and particularly relates to transdermal ointment and a drug-loaded composition and a drug-loaded preparation thereof. The drug-loaded composition comprises a matrix, a cosolvent, a transdermal enhancer and a defoaming agent, wherein with respect to 100 parts by weight of the matrix, the content of the cosolvent is 50-110 parts by weight, the content of the transdermal enhancer is 30-100 parts by weight, and the content of the defoaming agent is 3-15 parts by weight. The invention further provides a transdermal ointment for animal parasite expelling, which comprises a drug-loaded preparation and an active drug dispersed in the drug-loaded preparation, wherein based on the total weight of the transdermal ointment, the content of the active drug is 1-30 wt%; and the active drug is a nitromethylene systemic insecticide and/or a macrolide antibiotic. The transdermal ointment formed by the composition disclosed by the invention has a good drug transdermal amount, transdermal depth and residence time, is safe and convenient to use, and has a good application prospect.

The invention discloses a spacing antiskid vascular scaffold capable of slowly discharging drugs. The spacing antiskid vascular scaffold comprises a plurality main scaffolds which are parallelly arranged at intervals, the main scaffolds are fixedly connected through auxiliary scaffolds, a plurality of through holes are formed in the main scaffolds, the auxiliary scaffolds are inserted into the through holes, gaps are reserved among the auxiliary scaffolds and the outer side walls of the main scaffolds, drug cavities are formed among the main scaffolds and the auxiliary scaffolds, and drug discharging holes are formed in one side, close to the outer wall of the corresponding main scaffold, of each drug cavity. According to the vascular scaffold, the main scaffolds are arranged at intervals,antiskid effect is further enhanced, the action time of thrombolysis drugs can be greatly prolonged through action of the drug cavities and the drug discharging holes, and the vascular scaffold is quite effective and worthy of popularization.

The invention belongs to the technical field of medicines, and particularly relates to extracellular matrix imitated eye drops and a preparation method thereof. Particularly, the eye drops are prepared from the following components in parts by weight: 1-20 parts of Lifitegrast, 0.1-5 parts of heparan sulfate, 1-10 parts of sodium hyaluronate, 0.01-0.1 part of growth factors, 0.1-1 part of collagen and 200-500 parts of water. Once conea is injured, the extracellular matrix imitated eye drops prepared by the invention can repair the cell communication channel of the conea by adjusting a biological function of an extracellular matrix, so that the physiological function of the conea is adjusted and repaired.