Oral adhesive powder and preparation method thereof

A technology of oral adhesion and honeysuckle extract is applied in the directions of pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. The effect of shortening the fasting time, reducing the frequency of drug use, and prolonging the effect of the drug

Inactive Publication Date: 2017-10-13
TAISHAN MEDICAL UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0003] In terms of local treatment of oral ulcers, the current traditional Chinese medicine therapy often uses powder, and the curative effect is often not good.
Because the current powder has the following disadvantages: 1. The dissolution and adsorption are slow, so that the medicine on the ulcer surface is often washed away by the self-cleaning force of saliva and cannot be effectively covered in time, which affects the efficacy of the medicine
3. Some existing powders need to be dipped with a cotton swab when taking medicine, which is inconvenient to take.
4. Some dispersants have poor fluidity, which is easy to block the nozzle and affect the use
5. It is easy to cause choking and coughing

Method used

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  • Oral adhesive powder and preparation method thereof
  • Oral adhesive powder and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0027] The result that other powders are carried out contrast experiment with powders of the present invention below in the form of list is as follows:

[0028] Table 1. Comparison of in vitro adhesion between Adhesive Powder and other powders

[0029]

[0030] As can be seen from Table 1, the present invention is obviously superior to other powders in adhesion, which is mainly because we have added CMC-Na and carbomer to thicken, emulsify, strengthen toughness, and improve viscosity.

[0031] Table 2. Comparison of adhesion time in vivo between Adhesive Powder and other powders

[0032]

Bingboron Powder

Ulcer powder

Watermelon Frost

Adhesive powder

time (min)

3±0.3

2±0.2

3±0.3

26±0.4

[0033] As can be seen from Table 2, the present invention is obviously superior to other powders in oral cavity adhesion time, which is mainly because we have added CMC-Na and carbomer to improve the adhesion time.

[0034] Table 3. Comparis...

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Abstract

An oral adhesive powder, the components of which are as follows: honeysuckle extract, Scutellaria baicalensis extract, CMC-Na, carbomer, montmorillonite, borneol, menthol mannitol. Compared with other powders, the Oral Adhesive Powder of the present invention has a longer duration of drug action due to its strong adhesion, longer intervals between medications, reduced times of drug use, shortened course of treatment, and improved curative effect. It shortens the fasting time and is more suitable for infants and young children.

Description

technical field [0001] The invention relates to a new pharmaceutical dosage form - oral adhesive powder. Background technique [0002] Oral ulcer is a common oral mucosal disease with a long course of disease and is difficult to cure. Epidemiological survey data show that the incidence of oral ulcer is about 20%, and the number of patients is huge. At present, oral ulcers can be treated with drugs such as anti-inflammatory, anti-infection, anti-virus, sterilization, wound healing promotion and immune resistance enhancement. [0003] In the local treatment of oral ulcers, the current traditional Chinese medicine therapy often adopts powder, and the curative effect is often not good. Because the powder has the following disadvantages at present: 1. The dissolution and adsorption are slow, so that the medicine on the ulcer surface is often washed away by the self-cleaning force of saliva and cannot be effectively covered in time and affects the drug effect. 2. Due to the lack...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/539A61K9/14A61K47/38A61K47/26A61P1/02A61K31/045A61K33/06
Inventor 张燕堂张颖张强
Owner TAISHAN MEDICAL UNIV
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