Composition for oral ulcer, oral ulcer film and preparation method of oral ulcer film

A technology of oral ulcer and composition, which is applied in the field of oral ulcer composition, can solve the problems of unsatisfactory film mechanical strength, poor continuous treatment effect, poor oral adhesion, etc., to prolong the drug action time and lasting anti-inflammatory healing , the effect of good degradability

Pending Publication Date: 2021-05-25
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current oral ulcer patches are instant patches, the continuous treatment effect is poor, and frequent administration is still required; and the mechanical strength of the patches is not ideal, the adhesion to the oral cavity is not good, and it is easy to fall off after absorbing water and swelling

Method used

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  • Composition for oral ulcer, oral ulcer film and preparation method of oral ulcer film
  • Composition for oral ulcer, oral ulcer film and preparation method of oral ulcer film
  • Composition for oral ulcer, oral ulcer film and preparation method of oral ulcer film

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preparation example Construction

[0094] The invention provides a kind of preparation method of oral ulcer film, it comprises the steps:

[0095] Dissolving the film forming agent to obtain solution A;

[0096] adding the composition and glycerin to solution A to obtain solution B;

[0097] Degassing the solution B, then putting it into a mold to form a film, drying and demoulding to obtain a film; and

[0098] The film is obtained by soaking the film in calcium chloride solution, then taking it out and drying it.

[0099] In a preferred embodiment of the present invention, wherein the film-forming agent is sodium alginate and polyvinyl alcohol, preferably, in parts by weight, the sodium alginate is 5-30 parts, and the polyvinyl alcohol Vinyl alcohol is 5-30 parts.

[0100] In a preferred specific embodiment of the present invention, wherein, the composition includes hyaluronic acid or its salt, ectoine, lidocaine, iodine, recombinant human epidermal growth factor, vitamin C, vitamin B 2 ;

[0101] Prefer...

Embodiment 1

[0139] Weigh 15g of polyvinyl alcohol, add an appropriate amount of purified water, heat and stir in a water bath at 85°C for 4 hours until it dissolves completely, continuously replenish the water reduced by evaporation, cool to room temperature for later use, and obtain solution A1;

[0140] Weigh 15g of sodium alginate, add an appropriate amount of purified water, stir at room temperature for 4 hours until completely dissolved, and obtain solution A2;

[0141] Weigh 0.2g sodium hyaluronate with a molecular weight of 50wDa, 0.5g ectoine, 0.002g lidocaine, 0.002g iodine, 0.0003g recombinant human epidermal growth factor, 0.1g vitamin C, 0.001g vitamin B 2 and 10g of glycerin were added to the solution A2, and stirred for 1.5h until the solution was evenly dissolved to obtain the solution B1;

[0142] Stir solution A1 and solution B1 with a stirrer at room temperature for 15 minutes until uniform, and obtain solution B;

[0143] Put the solution B at room temperature for 2.5 ho...

Embodiment 2

[0147] Weigh 20g of polyvinyl alcohol, add an appropriate amount of purified water, heat and stir in a 95°C water bath for 4 hours until completely dissolved, continuously replenish the water reduced by evaporation, cool to room temperature for later use, and obtain solution A1;

[0148] Weigh 20g of sodium alginate, add an appropriate amount of purified water, stir at room temperature for 4 hours until completely dissolved, and obtain solution A2;

[0149] Weigh 0.5g of sodium hyaluronate with a molecular weight of 80wDa, 1g of ectoine, 0.004g of lidocaine, 0.003g of iodine, 0.0004g of recombinant human epidermal growth factor, 0.2g of vitamin C, and 0.002g of vitamin B 2 and 20g of glycerin were added to the solution A2, and stirred for 2 hours to dissolve evenly to obtain the solution B1;

[0150] Stir solution A1 and solution B1 with a stirrer at room temperature for 20 minutes until uniform, and obtain solution B;

[0151] Put the solution B at room temperature for 3 hou...

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Abstract

The invention discloses a composition for oral ulcer, an oral ulcer film and a preparation method of the oral ulcer film. The composition comprises hyaluronic acid or a salt thereof, ectoine, lidocaine, iodine, a recombinant human epidermal growth factor, vitamin C and vitamin B2. The composition provided by the invention can be used in a compatible manner, can play a good role in relieving pain, diminishing inflammation for a long time and promoting healing, and can also supplement vitamins lacking in the body. The hyaluronic acid or the salt thereof also has outstanding cell affinity, can interact with the recombinant human epidermal growth factor and can be combined with a specific cell receptor, so that the human body can better absorb the recombinant human epidermal growth factor, and the healing of ulcer can be better promoted; and the oral ulcer film prepared from the composition has good biocompatibility and degradability, good film-forming property, good softness and strong stickiness, and can better accelerate wound healing.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a composition for oral ulcers, an oral ulcer film and a preparation method thereof. Background technique [0002] Oral ulcer, commonly known as "oral sore", is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, tongue belly, buccal mucosa, vestibular groove, soft palate and other parts. The mucosa in these parts lacks stratum corneum. or poor keratosis. Tongue ulcers refer to oral ulcers that occur on the tongue and the abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning pain is obvious. In severe cases, it will also affect eating and speaking, causing great inconvenience to daily life; Symptoms such as swollen lymph nodes. [0003] At present, the treatment methods for oral ulcers are mainly divided into two categories: one is local treatment, including tablets, powders, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/18A61K9/70A61K47/32A61K47/36A61P1/02A61P7/04A61P29/00A61P31/02A61P31/04A61K31/167A61K31/375A61K31/505A61K31/525A61K31/728A61K33/18
CPCA61K9/006A61K31/728A61K31/505A61K31/167A61K33/18A61K38/1808A61K31/375A61K31/525A61K9/7007A61K47/36A61K47/32A61P1/02A61P29/00A61P7/04A61P31/02A61P31/04
Inventor 田晨颖李超宓妍妍韩月梅刘建建郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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