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Preparation method and applications of ilaprazole sodium liposome

A technology of ilaprazole sodium lipid and ilaprazole sodium, which is applied in the field of preparation of ilaprazole sodium liposome, can solve the problems of large adverse reactions, slow onset of action and the like, and achieves inhibition of gastric acid secretion and onset of effect Fast, significant effect on peptic ulcer

Inactive Publication Date: 2016-10-19
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantage is that the adverse reactions are large and the onset is slow
There is no ilaprazole sodium liposome preparation on the market, and the application of this patent can make up for this part of the gap

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Specific Embodiments Example 1 Weigh lecithin and cholesterol at a molar ratio of 2:1, add ilaprazole sodium composition to 4mL absolute ethanol in a water bath at 55°C until dissolved, and inject 20mL pH6. In the hydration medium of 0-8.0 phosphate buffer solution, stir and hydrate for 30 minutes, remove ethanol by rotary evaporation (55°C, vacuum degree 0.1MPa), cool rapidly, and homogenize under ultra-high pressure (pressure 25000PSI, cycle 2-4 times), Then freeze-dry, that is.

Embodiment 2

[0014] Example 2 Ilaprazole Sodium Tablets 10mg (calculated as ilaprazole sodium) Prescription: 500 parts of ilaprazole sodium liposome, 500g of lactose, 1000g of crospovidone, 1000g of magnesium stearate, made 1000 pieces.

[0015] Preparation method: Take ilaprazole sodium liposome, lactose, crospovidone, and magnesium stearate according to the prescription amount, mix them evenly, and directly compress them to form tablets.

Embodiment 3

[0016] Example 3 Ilaprazole Sodium Capsules 20 mg (calculated as Ilaprazole Sodium) Prescription: 1,000 parts of Ilaprazole Sodium Liposome, 2,000 g of Microcrystalline Cellulose, 1,000 g of Sodium Carboxymethyl Starch, 1,000 g of Magnesium Stearate , made into 1000 capsules.

[0017] Preparation method: Take ilaprazole sodium liposome according to the prescription amount, mix them evenly with microcrystalline cellulose, sodium carboxymethyl starch, and magnesium stearate, and fill them in a capsule machine to obtain capsules.

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PUM

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Abstract

The present invention provides a preparation method and applications of ilaprazole sodium liposome, wherein the method is characterized in that lecithin and cholesterol are adopted as film materials and an ethanol injection method is adopted to encapsulate an ilaprazole sodium composition into the ilaprazole sodium liposome. According to the present invention, the ilaprazole sodium liposome has characteristics of targeting property, slow releasing property, cell affinity, histocompatibility, no toxicity, and drug stability increasing; the obtained preparation has characteristics of high stability, low side effect and long drug acting time, and further has effects of gastric acid secretion inhibiting, gastric mucosa protecting, and Helicobacter pylori killing; and with the application of the ethanol injection method to prepare the ilaprazole sodium liposome, the continuous production can be achieved, and the industrialized requirement can be well met, such that the broad application prospects are provided in the field of medicine.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method and application of ilaprazole sodium liposome. Background technique [0002] Peptic ulcer (peptic ulcer) is one of clinically common and frequently-occurring diseases. my country is a high-incidence area for ulcers. According to statistics, about 10% of the population has suffered from this disease in their lifetime. Clinically, duodenal ulcer is more common than gastric ulcer, and the ratio of the two is about 1.56-5.6:1. Gastric ulcer and duodenal ulcer are chronic diseases with high recurrence coefficient, and require long-term treatment, especially for patients with gastric ulcer and duodenal ulcer caused by Helicobacter pylori infection. For patients, the price factor of medicines is very important. Therefore, the majority of patients urgently need products with good curative effect, high safety, low price, small adverse effects, good durability, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/4439A61K47/24A61P1/04A61P31/04A61K31/4164A61K33/00
Inventor 邓学峰耿华靖刘澎
Owner 邓学峰
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