Degradable high-molecular drug-loading fibrous membrane used for repairing scars

Abstract

The invention discloses a degradable high-molecular drug-loading fibrous membrane used for repairing scars. According to the invention, 0.01 to 5 parts of a scar repairing medicine by net weight are dissolved and dispersed in 100 parts of a biodegradable high-molecular material solution by weight, such that a mixed system is obtained. The mixed system is transferred into a spray liquid storing device. Through the altering of electrostatic spinning parameters, a haphazardly or directionally arranged target fibrous membrane is obtained. The electrostatic spun membrane provided by the invention has high porosity and good permeability, such that side-effects caused by poor permeability of a sealed membrane can be solved. The substrate material of the membrane is degradable high molecules. According to the invention, the medicine is sealed in the fibers, such that the stability of the structure of the medicine can be ensured; also, the medicine can be slowly released under the controlling of the degradation of the high-molecular material, such that the effect duration of the medicine is longer than that of traditional scar-repairing preparations or ointments. Further, the membrane can be cut into any required shape according to the dimension of a scar. Therefore, the membrane is easy to be customized and utilized.

Description

technical field [0001] The invention relates to medical rehabilitation materials, in particular to the technical field of degradable polymer drug-loaded fiber membrane for scar repair and its preparation method. Background technique [0002] Scar is a normal process of human skin injury (such as trauma, burn, surgical incision, infection, etc.) repair. The main reason for its formation is the excessive deposition of collagen in the dermis and subcutaneous tissue. Scar formation not only affects the appearance, but is often accompanied by symptoms such as itching and pain after the wound heals; if the scar occurs in the joint or grows across the joint, it will further affect its normal physiological function. [0003] There are nine types of scars in theory, but five types are common: atrophic scars, contracture scars, hypertrophic scars, keloids, and malignant changes of scars. Atrophic scars and contracture scars have little impact on the appearance and normal physiologic...

AI Technical Summary

Problems solved by technology

[0007] 1. Most of these films are prepared by cast film method, they are dense and have poor air permeability

[0008] 2. Based on the method of directly applying the medicine, it must be applied every day. For the treatment of scars, which requires a relatively long period, the treatment process needs to be repeated cumbersomely, and it may be disturbed by other things and forget to apply the medicine, resulting in unsatisfactory treatment effect

[0009] 3. Most of the films based on silicone gel have a certain degree of viscosity, and the part of the drug-loaded film needs a supporting substrate at the bottom, which directly prevents the contact between the drug and the scar and reduces the efficacy of the drug.

[0010] Clinically, it is also treated by surgical resection and injection, which not only increases the pain of the patient, but also increases the economic burden on the patient for multiple injections.