Transdermal ointment and drug-loaded composition and drug-loaded preparation thereof

A technology of composition and transdermal enhancer, which is applied in the field of drug-loaded composition forming the drug-loaded preparation, which can solve the problems of high proportion of organic solvents, easily irritated pet skin, itching, erythema, etc., and achieve skin permeability Good sex, long drug action time, and improved safety

Pending Publication Date: 2022-01-18
江苏集萃新型药物制剂技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the drugs containing imidacloprid or moxidectin sold in the domestic market are liquid preparations, drops or pouring preparations. Most of the preparations contain a very high proportion of organic solvents, which are easy to irritate the skin of pets, causing itching, erythema, etc. symptom

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] (1) Prepare the composition

[0072] Base: a total of 100 parts by weight, composed of glyceryl monostearate and petrolatum at a weight ratio of 1:2;

[0073] Co-solvent: a total of 75 parts by weight, composed of medium-chain triglycerides and propylene glycol at a weight ratio of 1:1.5;

[0074] Transdermal enhancer: a total of 65 parts by weight, composed of diethylene glycol monoethyl ether and caprylic capric acid macrogolglyceride with a weight ratio of 1.5:1;

[0075] Defoamer: 8 parts by weight in total, composed of the first simethicone (viscosity 30000cst, average molecular weight 92500Da) and the second simethicone (viscosity 1000cst, average molecular weight 28200Da) in a weight ratio of 1:10 ;

[0076] Shaping agent: 10 parts by weight of aluminum starch octenyl succinate (Dry Flo TS, Nouryon, the following are the same);

[0077] Antioxidant: a total of 0.03 parts by weight, 2,6-di-tert-butyl-p-cresol (BHT);

[0078] Medicine: parts by weight make the ...

Embodiment 2

[0087] (1) Prepare the composition

[0088] Substrate: a total of 100 parts by weight, composed of lanolin and sodium lauryl sulfate at a weight ratio of 1:1.5;

[0089] Co-solvent: a total of 80 parts by weight, composed of medium-chain triglycerides and propylene glycol at a weight ratio of 1:2;

[0090] Transdermal accelerator: a total of 55 parts by weight, composed of diethylene glycol monoethyl ether and caprylic capric acid macrogolglyceride in a weight ratio of 1:1;

[0091] Defoamer: a total of 10 parts by weight, composed of the first type of simethicone (viscosity of 30000cst, average molecular weight of 92500Da) and the second type of simethicone (viscosity of 200cst, average molecular weight of 9500Da) in a weight ratio of 1:8 ;

[0092] Shaping agent: 7 parts by weight of Dry Flo TS;

[0093] Antioxidant: 0.05 parts by weight of BHT.

[0094] Medicine: parts by weight make the medicine account for 12% by weight of the total composition, and consist of imidacl...

Embodiment 3

[0098] (1) Prepare the composition

[0099] Substrate: 100 parts by weight in total, composed of liquid paraffin and Span 80 at a weight ratio of 1:2.5;

[0100] Co-solvent: a total of 70 parts by weight, composed of medium-chain triglycerides and ethanol at a weight ratio of 1:1;

[0101] Transdermal accelerator: a total of 70 parts by weight, composed of diethylene glycol monoethyl ether and caprylic capric acid macrogolglyceride in a weight ratio of 1:1;

[0102] Defoamer: 7 parts by weight in total, composed of the first simethicone (viscosity 60000cst, average molecular weight 115000Da) and the second simethicone (viscosity 100cst, average molecular weight 6200Da) in a weight ratio of 1:15 ;

[0103] Shaping agent: 8 parts by weight of Dry Flo TS;

[0104] Antioxidant: 0.02 parts by weight of BHT.

[0105] Drug: parts by weight make the drug account for 12% by weight of the total composition, and consist of imidacloprid and moxidectin in a weight ratio of 3:1.

[010...

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Abstract

The invention relates to a medicine preparation, and particularly relates to transdermal ointment and a drug-loaded composition and a drug-loaded preparation thereof. The drug-loaded composition comprises a matrix, a cosolvent, a transdermal enhancer and a defoaming agent, wherein with respect to 100 parts by weight of the matrix, the content of the cosolvent is 50-110 parts by weight, the content of the transdermal enhancer is 30-100 parts by weight, and the content of the defoaming agent is 3-15 parts by weight. The invention further provides a transdermal ointment for animal parasite expelling, which comprises a drug-loaded preparation and an active drug dispersed in the drug-loaded preparation, wherein based on the total weight of the transdermal ointment, the content of the active drug is 1-30 wt%; and the active drug is a nitromethylene systemic insecticide and/or a macrolide antibiotic. The transdermal ointment formed by the composition disclosed by the invention has a good drug transdermal amount, transdermal depth and residence time, is safe and convenient to use, and has a good application prospect.

Description

technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a transdermal ointment, a drug-loaded preparation for forming the transdermal ointment, and a drug-loaded composition for forming the drug-loaded preparation. Background technique [0002] In recent years, my country's pet market has continued to expand, and the number of dogs and cats kept has continued to increase. Pet diseases have attracted more and more attention, and internal and external parasites are one of the important causes of pet diseases. The external parasites of cats and dogs, such as mites, lice, and fleas, have a high infection rate, which can cause skin itching, hair loss, redness, swelling, and scabs of cats and dogs, seriously affecting the health of pets. In addition, ectoparasites may also be transmitted to the host, causing harm. Internal parasites of cats and dogs, such as Toxocara canis, Ancylostoma canis, Ancylocephalus, etc., after cats and dogs are in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/4439A61K31/365A61K47/10A61K47/14A61P33/00
CPCA61K9/06A61K9/0014A61K31/4439A61K31/365A61K47/10A61K47/14A61P33/00A61K2300/00
Inventor 全丹毅王翔宇
Owner 江苏集萃新型药物制剂技术研究所有限公司
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