29 results about "Caprylic/Capric Acid" patented technology

The invention provides a liquid crystal bionic water-locking and oxygen-permeating nursing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The skin care product is prepared from components in percentage by weight as follows: 20%-40% of glycerin, 5%-10% of hydrogenated lecithin, 5%-10% of phytosterols, 0.1%-0.5% of sodium stearoyl glutamate, 0.01%-0.05% of sodium methyl stearoyl taurate, 0.1%-1% of ceramide NP, 1%-10% of caprylic / capric triglyceride, 1%-10% of squalane, 0.1%-1% of tocopheryl acetate, 0.01%-0.3% of DNA sodium, 0.001%-0.1% of fibronectin and the balance of water. 0.001-0.1% of soluble collagen and the balance of water. The liquid crystal bionic water-locking and oxygen-permeating nursing composition provided by the invention can better form a breathable protective film on the surface of skin, reduce water loss of the skin and help to repair a damaged skin barrier, so that the water-locking and oxygen-permeating nursing effect is achieved.

The invention relates to pharmaceutical compositions comprising a peptide, such as a GLP-1 peptide and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The invention discloses a traditional Chinese medicine composition capable of reducing transaminase increase and a preparation method of the traditional Chinese medicine composition, and belongs to a medicine for protecting the liver and dispelling the effects of alcohol, which is prepared by utilizing traditional Chinese medicine compound compatibility and extraction and wrapping technologies. Comprising the following steps: drying and crushing radix bupleuri, radix puerariae, ligusticum chuanxiong hort and fructus lycii to obtain traditional Chinese medicine powder; the traditional Chinese medicine powder is subjected to ultrasonic extraction to obtain a dissolution solution; sequentially carrying out centrifugation, filtration, evaporation, drying and modification treatment on the dissolution liquid to obtain modified effective component micro powder; the modified effective component micro powder, glyceryl monostearate, tricaprylin and an ethanol solution with the mass fraction of 70% are mixed and then evaporated to obtain a lipid membrane; mixing soybean lecithin, Tween 80 and deionized water to obtain a compound emulsifier; the compound emulsifier and the lipid membrane are mixed and then sequentially subjected to drying and pulse ultrasound to obtain the traditional Chinese medicine composition capable of reducing transaminase increase.

The invention belongs to the technical field of environmental engineering and chemical separation, and particularly relates to a deep-eutectic solvent composition for efficiently extracting phenolic compounds and a preparation method of the deep-eutectic solvent composition. The deep-eutectic solvent composition for efficiently extracting the phenolic compounds, provided by the invention, consists of a hydrogen bond acceptor and a hydrogen bond donor in a molar ratio of (1-2): (1-9), the hydrogen bond donor comprises n-caprylic acid or n-hexyl alcohol; the hydrogen bond receptor comprises 1-ethyl-3-methylimidazole chloride or tetrabutylammonium bromide. The eutectic solvent composition has the advantages of high partition coefficient, low viscosity, high selectivity, rapid phase separation, environmental friendliness and the like, can efficiently extract phenol, resorcinol, o-cresol, m-cresol and p-cresol, and has single-stage extraction efficiency gt; the regeneration rate is high, and the method is suitable for high-concentration phenolic wastewater, polyhydroxy phenolic wastewater, continuous process and low-toxicity emission requirement scenes.

Proposed are preparations comprising (i) a mixture of substances comprising (a) one, two or more compounds selected from the group consisting of (a1) alcohol monoterpenes of the formula (I) where R1 is H or methyl, R2 is H or C2-alkenyl, and R3 is a linear or branched, saturated or unsaturated hydrocarbon radical having 4 to 10 carbon atoms, and their enantiomers, diastereomers, racemates, solvates and physiologically acceptable salts, and / or (a2) bicyclic epoxy monoterpenes, (b) at least two lactones of the formula (II) where R4 is H or methyl, R5 is a linear or branched, saturated or unsaturated hydrocarbon radical having 2 to 10 carbon atoms and n is the number 1 or 2, and their enantiomers, diastereomers and racemates, and (c) one, two or more Solvent selected from the group consisting of ethanol, water, dipropylene glycol (DPG), diethyl phthalate (DEP), propylene glycol (PG),Isopropyl myristate (IPM), isopropyl palmitate (IPP), triethyl citrate (TEC), triacetin (TRI), 1,2-propanediol, 1,3-propanediol, propanetriol, pentanediol, hexanediol, octanediol, decanediol, dodecanol, 4-hydroxyacetophenone, butylene glycol, pentylene glycol, hexylene glycol, decylene glycol, propylene carbonate, butylene carbonate, glycerol carbonate, 2-benzylheptanol, trimethyl hydroxypentyl isobutyrate, glyceryl caprylate, ethylhexylglycerin, benzyl benzoate (BB), and optionally (d) further flavorings or fragrances selected from the group consisting of 3-phenylbutanal, acetylmethylcarbinol, anethole, anisyl acetate, dihydroeugenol, linalyl formate, 2-methyldecanal, 2-Benzyl-2-methylbut-3-ene nitrile, 3-hexenyl acetate, styralyl acetate, citronellal, cinnamyl acetate, rhubafuran, betalonone, anther, prenyl acetate, 2-phenylpropanal, 4-(4-hydroxyphenyl)butan-2-one, ethylphenoxyacetate, isoraldein, gamma-terpinene, Limonene, Neocyclocitral, Methyl Lavender Ketone, Styralyl Propionate, Phenyl Ethyl Propionate, Limonenal,4-Isopentylcyclohexanol, 4-methyl-2-phenyl-3,6-dihydro-2H-pyran / 4-methylene-2-phenyl-tetrahydropyran, hydrocitronitrile, phenoxanol, isoamylphenyl acetate, damascone, silvial, nectaryl, ambroxide, acetylpyrazine, trimethylpyrazine, isoamyl acetate, cresyl methyl ether para, filbertone, cyclohexyl acetate, heliotropin, acetophenone, anisaldehyde, methylacetophenone para, veratraldehyde, methyl anisate and vertoprenal, and (ii) aldehydes of the formula (III) where R6 is a saturated or unsaturated, linear hydrocarbon radical, and / or (iii) free fatty acids of the formula (IV) where R7 is a linear or branched, saturated hydrocarbon radical.

The invention belongs to the technical field of ecological prevention and control of agricultural pests, and relates to a peach fruit moth sex pheromone communication interference composition derived from host plants. The interferent is selected from at least one of trans-2-heptanal, trans-2-hexenyl acetate, leaf acetate and octanoic acid. The interferent can be used for predicting, forecasting, preventing and controlling peach fruit moths. The communication interferent provided by the invention can influence chemical communication between female and male imagoes of the peach fruit moth. The method can be combined with sex pheromones to be used for predicting, forecasting, preventing and controlling the peach fruit moths, and a new combination is provided for ecological prevention and control of the peach fruit moths.

This invention discloses a method for preparing capsaicin-like substances by temperature-responsive eutectic solvent extraction, comprising the following steps: drying Yunnan chili peppers (after removing stems and seeds), pulverizing, sieving, and collecting the chili powder; mixing lidocaine (HBA) with six alkane-chain carboxylic acids (valerate, hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, and lauric acid) at a 1:1 molar ratio to form a homogeneous and transparent liquid, TRDES; weighing the chili powder, adding it to the TRDES aqueous solution, and extracting by shaking; after extraction, centrifuging, and diluting the supernatant to obtain capsaicin-like substances. This invention uses temperature-responsive eutectic solvent extraction to prepare capsaicin-like substances, which is simple, highly efficient, and allows for the recycling of extraction reagents, effectively saving resources. It has significant practical and industrial value for promoting the large-scale production of capsaicin-like substances and enhancing their high-value applications.

The present invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a semaglutide pharmaceutical composition and a preparation method thereof. The semaglutide pharmaceutical composition of the present invention comprises semaglutide, vorapaxar fumarate, sodium N-(8-(2-hydroxybenzoyl)amino) octanoate (SNAC), and pharmaceutically acceptable excipients. The dosage of SNAC in the composition is small. Vorapaxar fumarate can rapidly adjust the pH, can stay on gastric parietal cells for a long time and be more stable in an alkaline environment for a longer time, improve the dissolution of semaglutide, and the preparation has good stability.

The utility model belongs to capric acid glyceride production equipment technical field, concretely relates to a kind of enzyme synthesis capric acid glyceride reaction kettle, including reaction kettle, agitator, it is characterized by: reaction kettle top is equipped with the quick sampling mechanism installed by tank top flange one, tank top flange two, quick sampling mechanism includes the pipeline system of venturi, suction tube, connecting pipe, wherein the top end of suction tube is connected to venturi throat, the bottom end of suction tube is inserted into the inside of reaction kettle, venturi two ends are connected nitrogen valve and backwash valve respectively, backwash valve connects reaction kettle inside, connecting pipe connects sample release pipe, sample release valve is installed on sample release pipe, nitrogen valve is connected with nitrogen pipeline.The flow of nitrogen in venturi safely and conveniently takes out reaction liquid, effectively improves sampling convenience and safety;Reaction liquid can be circulated in quick sampling mechanism and reaction kettle to avoid sample cross-contamination.

The invention provides a skin care composition capable of repairing a skin barrier, mildly relieving and non-irritating as well as a preparation method and application of the skin care composition. The skin care composition is prepared from the following raw materials: a plant extract, euglena gracilis polysaccharide, xylitol-based glucoside, hydrolyzed glucosaminoglycan, acetyl dipeptide-1 cetyl ester, ascorbic acid polypeptide, dipropylene glycol, acetyl hexapeptide-8, glyceryl polyether-26, alanine, caprylic / capric triglyceride, hydroxypropyl cyclodextrin, xanthan gum and water. The skin care composition disclosed by the invention can form a protective film, enhance the water locking capacity, protect the stability of various active ingredients, continuously release the active ingredients during use, permeate into skin, supplement intercellular lipid in the inner layer of the skin, effectively inhibit release of inflammatory factors, promote metabolism and renewal of skin cells, and improve the skin care effect. The effects of effectively prolonging and repairing the skin barrier and relieving the skin are achieved, and the effect is mild and non-irritant.

The invention discloses a preparation method of an egg yolk antibody, which comprises the following steps of: preparing a vaccine composition from a porcine epidemic diarrhea virus strain with the microbial preservation number of CGMCC (China General Microbiological Culture Collection Center) NO.46190, inoculating 90-180-day-old laying hens with the vaccine composition to prepare hyper-immune eggs, and extracting the egg yolk antibody in the hyper-immune eggs by using an octanoic acid extraction method. The egg yolk antibody can effectively prevent porcine epidemic diarrhea, is good in specificity, safe and effective, and has a clinical application prospect.

The invention belongs to the technical field of preparation of monoglyceride, and discloses a preparation system of glycerol monocaprylate and a method for preparing glycerol monocaprylate by using the preparation system. The preparation system comprises a feeding system, a loop reaction system and a post-treatment system, wherein the feeding system comprises a weighing type feeding device as well as a glycerol storage tank and an octanoic acid storage tank which are connected to the weighing type feeding device; the loop reaction system comprises a loop reactor, a loop circulating pump, an external circulation heat exchanger and a gas-liquid separation device; the post-treatment system comprises a flash evaporation device, a molecular distillation device and a finished product receiving device; a feed port of the flash evaporation device is connected to a discharge port of the loop reactor, and a discharge port at the bottom of the flash evaporation device is connected with a feed port of the molecular distillation device through a pipeline; a discharge hole in the top of the molecular distillation device is connected with a finished product receiving device. By utilizing the preparation system and the preparation method provided by the invention, the glycerol monocaprylate with high yield and purity can be prepared, and the preparation method is green and efficient.

The invention relates to a down feather fiber thermal insulation material and a compounding method thereof, and belongs to the technical field of thermal insulation material production, the thermal insulation material is a porous composite fiber prepared by a melt spinning technology, and the raw materials of the thermal insulation material comprise modified down feather fiber powder, isotactic polypropylene and polyurethane, the down feather fiber powder is obtained through modification treatment of 2, 3-epoxypropyltrimethylammonium chloride and caprylic acid. According to the invention, down feather fiber powder, isotactic polypropylene and polyurethane, which are modified by a modification liquid containing 2, 3-epoxypropyltrimethylammonium chloride and caprylic acid, are used as raw materials to prepare the porous composite fiber with spacing heat preservation and moisture resistance.

The invention discloses a cactus external preparation and a preparation method thereof, and relates to the technical field of skin external preparations and preparation thereof.The cactus external preparation comprises, by mass, 4.5% of a cactus oligosaccharide compound, the molar ratio of mannan oligosaccharide to arabinogalactan in the cactus oligosaccharide compound is 3: 2, and the cactus oligosaccharide compound contains beta-1, 4 glucosidic bond modification groups; 6% of sericin temperature-sensitive microspheres, the particle size of the microspheres being 200-300 nm, and the phase transition temperature being 32-35 DEG C; according to the invention, staphylococcus epidermidis is activated to secrete antibacterial substances in a targeted manner through the cactus oligosaccharide compound, a physical barrier is formed in combination with the sericin temperature-sensitive microspheres, lactobacillus extracellular vesicles inhibit metabolism of propionibacterium acnes, glycerol caprylate selectively interferes with the fluidity of a pathogenic bacterium membrane, and konjac glucomannan regulates immunity; and a flora regulation and control-barrier protection-immune regulation system is constructed under the assistance of a pulsed electric field pretreatment process and the like, so that the problems of flora imbalance and drug resistance caused by traditional sterilization are solved, and skin micro-ecological balance and inflammation blocking are realized.

The invention belongs to the technical field of veterinary drugs, and particularly discloses a permeation enhancer-containing fluralan-moxidectin nano drop and a preparation method thereof, the permeation enhancer-containing fluralan-moxidectin nano drop comprises the following components: fluralan, moxidectin, a permeation enhancer, glycosylglycerol, tocopheryl acetate, a cosolvent, modified chitosan, hydroxy acid salt, an antioxidant and the balance of a solvent; the permeation enhancer is prepared from phytosphingosine, beta-caryophyllene and caprylic / capric triglyceride according to the mass ratio of 1 to (0.2 to 2) to (0.2 to 1.8). According to the invention, the fluralan and the moxidectin are taken as active ingredients, and the permeation enhancer, the glycosylglycerol, the tocopheryl acetate, the modified chitosan, the hydroxy acid salt and the antioxidant are added, so that the permeation effect of the fluralan and the moxidectin is effectively improved, the transdermal absorption effect of the fluralan and the moxidectin is remarkably improved, and the stability of the drops is effectively improved.

The invention discloses a method for extracting antioxidants in semen nigellae based on a pH-responsive eutectic solvent, which comprises the following specific steps: mixing ethanolamine, octanoic acid and water according to a molar ratio of 1: 1: (2-6), and heating in a closed container in a constant-temperature water bath until a clear and transparent DES homogeneous liquid is formed; mixing the semen nigellae powder and the DES homogeneous liquid according to a solid-liquid ratio of 1: (25-50) g / mL, and performing ultrasonic-assisted extraction to obtain a mixed extracting solution; the mixed extracting solution is centrifuged, DES phases are collected, a phase change triggering agent is added into the mixed extracting solution, centrifugation is conducted again after vortex oscillation, a lower-layer water phase is collected, and the antioxidant of the semen nigellae is obtained. The antioxidant extracted through the method has high antioxidant activity, and the FRAP value gt of the antioxidant is measured through an FRAP method; and 20 [mu] mol / g.

The invention relates to pharmaceutical compositions comprising a peptide, such as a GLP-1 peptide and a salt of N-(8-(2-hydroxybenzoyl)amino)caprylic acid. The invention further relates to processes for the preparation of such compositions, and their use in medicine.

The invention provides a method for removing IgA (Immunoglobulin A) and IgM (Immunoglobulin M) in human immunoglobulin for intravenous injection. The method comprises the following steps: S1) dissolving plasma component II + III precipitates to obtain a dissolved solution; s2) precipitating and centrifuging the dissolved solution by adopting n-caprylic acid or sodium caprylate to obtain supernate; s3) performing anion exchange column chromatography on the supernate to obtain first flow-through liquid and first washing liquid; s4) mixing the first flow-through liquid with the first washing liquid to obtain a column chromatography collection liquid; s5) performing strong anion membrane chromatography on the column chromatography collection liquid to obtain second flow-through liquid and second washing liquid; s6) mixing the second flow-through liquid and the second washing liquid to obtain a membrane chromatography collection liquid, and S7) sequentially performing first concentration, dialysis, first sterilization, incubation, ultrafiltration and second sterilization on the membrane chromatography collection liquid to obtain the human immunoglobulin for intravenous injection without IgA and IgM. According to the method disclosed by the invention, the IgA and IgM removal efficiency is remarkably improved through a multi-stage purification process.

This invention discloses a medium-chain fatty acid disinfectant for meat products, its preparation method, and its application. The medium-chain fatty acid disinfectant for meat products, by weight, comprises 0.1-1 parts acidifier, 4-6 parts medium-chain fatty acid, 25-35 parts solubilizer, 10-20 parts plant-derived surfactant, and 38-61 parts water. The medium-chain fatty acid includes at least one of caprylic acid, nonanoic acid, and capric acid, and the solubilizer includes lactic acid. This invention's medium-chain fatty acid disinfectant for meat products uses medium-chain fatty acid as the main bactericidal component, combined with a solubilizer and a plant-derived surfactant. The synergistic solubilization effect of these two components enhances the solubilization effect of the medium-chain fatty acid, further improving the bactericidal effect. Therefore, this invention's medium-chain fatty acid disinfectant maintains excellent bactericidal effect even at low concentrations, and because of the low concentration, it does not cause yellowing of the meat product surface.

The invention discloses anti-blue-light, anti-oxidation and anti-pollution refreshing essence lotion and a preparation method thereof, and belongs to the technical field of skin care product preparation. Every 100 parts of the skin care product is prepared from the following components in parts by weight: 1.0 to 4.0 parts of trehalose, 5.0 to 10.0 parts of coconut oil alcohol-octoate / caprate, 2.0 to 5.0 parts of dibutyl adipate, 0.3 to 1.0 part of tocopheryl acetate, 0.01 to 0.08 part of blue copper peptide, 0.5 to 3.0 parts of a radix scutellariae extract, 5 to 12 parts of a humectant, 0.05 to 0.20 part of a thickening agent, 1.0 to 3.0 parts of a volatile solvent, 2 to 4.2 parts of an emulsifier, 0.55 to 1.15 parts of an anti-corrosion stabilizer and the balance of water. The essence lotion provided by the invention can synchronously realize triple protection effects of blue light resistance, pollution resistance and oxidation resistance, has extremely fresh and cool skin feeling which can be quickly absorbed and is not sticky and not greasy, and is particularly suitable for long-term daily use of oily and mixed skin.

The utility model discloses a caprylic capric triglyceride refining and purifying device which comprises an evaporating tank, the top of the evaporating tank is fixedly connected with a driving motor, an output shaft of the driving motor is fixedly connected with a rotating shaft, and the surface of the rotating shaft is fixedly connected with a mounting plate. Through cooperation of the evaporation tank, the driving motor, the rotating shaft, the mounting plate, the fixed shaft, the first stirring rod, the transmission mechanism, the second stirring rod, a third gear, a tooth ring, an evaporation pipe, a condensation box, a collection box, a feeding pipe and a discharging funnel, materials enter an inner cavity of the evaporation tank through the feeding pipe; an output shaft of a driving motor drives a fixing shaft to rotate through a rotating shaft and a mounting plate, a third gear is matched with a tooth ring, the third gear drives the fixing shaft to rotate, the fixing shaft drives a first stirring rod to rotate, and then the fixing shaft drives a second stirring rod to rotate through a transmission mechanism, so that materials are uniformly stirred, and the heating effect is improved; hot air enters the condensation box through the evaporation pipe and then is quickly liquefied.

The invention discloses dog serum immune globulin and albumin as well as a preparation method and application thereof, and relates to the technical field of biological products. The preparation method comprises the following steps: caprylic acid precipitation, one-step anion exchange chromatography, ultrafiltration concentration and virus inactivation: diluting dog serum to adjust the pH value, adding caprylic acid to precipitate impure protein, carrying out Capto Q anion exchange chromatography on the supernatant, collecting the flow-through liquid to obtain an immune globulin component, eluting with a buffer solution containing 0.2 M NaCl to obtain an albumin component, and carrying out one-step anion exchange chromatography on the albumin component. And respectively carrying out targeted ultrafiltration concentration and virus inactivation treatment to synchronously obtain two products. The process is simple and efficient, the defects of multi-step chromatography or a complex precipitation method are avoided, and the production cost is low; the purity of the prepared immunoglobulin is greater than or equal to 96%, the purity of albumin is greater than or equal to 96%, the recovery rate is in a reasonable range, the product quality is stable, and the safety requirements of biological products are met. The immune globulin and albumin can be applied to preparation of veterinary biological products, and efficient utilization of dog serum resources is realized.

The invention discloses a preparation method of flaxseed oligosaccharide, and belongs to the technical field of biological extraction. According to the method, HDES composed of L-menthol and octanoic acid is used as an organic phase, ammonium sulfate is combined to form a three-phase system, a microbubble-assisted interface separation technology is introduced, protein is selectively adsorbed through the high specific surface area of bubbles and the electrical effect of an interface, the protein is promoted to migrate to an intermediate phase, layering is accelerated, and efficient separation of polysaccharide and protein is achieved. Under the optimized gas dissolving and pressure releasing conditions, the system layering is rapid, the distribution selectivity is high, and the high-purity polysaccharide is obtained; further, through directional enzymolysis, polysaccharide is converted into oligosaccharide with a uniform structure and good activity. The process integrates extraction, purification and enzymolysis, has the characteristics of greenness, environmental protection, simplicity and convenience in operation and high yield, and provides a new technical approach for high-value utilization of the flaxseed cakes.

The present application relates to the technical field of wound dressings, and provides a curcumin-loaded pH / enzyme dual-responsive polysaccharide-protein-based emulsion gel dressing and a preparation method thereof.A stable three-dimensional network cross-linked matrix is constructed by using soybean protein fibrils and carboxymethyl chitosan, and curcumin is dissolved in caprylic capric triglyceride to obtain a dispersed phase, the obtained dispersed phase is subjected to homogenization treatment with the cross-linked matrix to obtain the curcumin-loaded pH / enzyme dual-responsive polysaccharide-protein-based emulsion gel dressing.The emulsion gel dressing prepared by the present application can realize the dual-responsive directional slow release of curcumin at the target site of a wound by means of the pH sensitivity of carboxymethyl chitosan and the enzyme degradability of soybean protein fibrils, and meanwhile, the curcumin has high encapsulation efficiency and stability, and has excellent antibacterial, anti-inflammatory and biocompatibility, so the emulsion gel dressing has a wide application prospect in the field of wound dressings.

The present application provides a kind of containing 2nm narrow molecular weight silk peptide and its preparation method, and belongs to the field of functional food and big health technology;Oral liquid takes D90≤2nm, PDI<0.2 narrow molecular weight hydrolysis silk fibroin peptide as core efficacy raw material, compound 800~1200Da small molecule sodium hyaluronate, sodium ascorbate, beta-glucan, with octanoyl hydroxamic acid, glycerol caprylate, three-dimensional plant preservative system of decoloring and tasteless rosemary extract;Raw material includes purified water, crystalline fructose, D-sorbitol, citric acid, sodium citrate, no artificial essence, no benzoic acid sodium, no nipagin chemical preservative.The present application 2nm narrow molecular weight silk peptide intestinal absorption efficiency is high, formula realizes collagen synthesis, endogenous water locking, antioxidant three-dimensional synergy;Finished product has no protein fishy smell, long-term storage stability, shelf life can reach 24 months, process is suitable for industrialized batch production, meet the market demand of high-end clean label oral cosmetic drink.

The invention relates to the technical field of functional food processing, in particular to sheep colostrum composite freeze-dried powder capable of assisting in reducing blood sugar and a preparation method of the sheep colostrum composite freeze-dried powder. According to the invention, lactobacillus helveticus and lactobacillus plantarum are compounded and cooperated to carry out biological conversion on sheep colostrum fermentation, so that release of substances such as hexanal and octanoic acid of goaty odor precursor substances can be reduced, and bad fishy odor of sheep colostrum can be effectively improved in sense; through cooperation with the fermented Chinese yam and poria cocos, the fishy smell of the sheep colostrum can be remarkably reduced in the aspects of smell and taste from the aspects of release reduction, blending and the like, and the bad flavor is improved. The sheep colostrum fermented by compounding lactobacillus helveticus and lactobacillus plantarum, and the Chinese yam and poria cocos fermented by lactobacillus plantarum are compounded, so that the sheep colostrum has a synergistic blood sugar reducing effect, and can be used for preparing products for assisting in reducing blood sugar.

The invention discloses a hydrolase DAH8 coding gene for synthesizing various fatty acid ethyl esters from a Burkholderia seminis source and an application of the hydrolase DAH8 coding gene. The amino acid sequence of the hydrolase DAH8 is as shown in SEQ ID NO.1, and the nucleotide sequence of the coding gene of the hydrolase DAH8 is as shown in SEQ ID NO.2. The invention belongs to the technical field of hydrolase and particularly discloses construction of a Burkholderia seminalis source hydrolase DAH8 encoding gene and an escherichia coli expression vector carrying the gene, and meanwhile, the invention further discloses application of the Burkholderia seminalis source hydrolase DAH8 to catalytic synthesis of ethyl butyrate, ethyl valerate, ethyl hexanoate, ethyl caprylate and ethyl caprate in a water phase system. The invention firstly provides a hydrolase DAH8 which has the capability of synthesizing fatty acid ethyl ester in a water phase system and is derived from Burkholderia seminalis and a coding gene of the hydrolase DAH8.

The invention discloses a method for preparing horse-derived immune globulin F (ab ') 2 by a sodium caprylate precipitation process, and belongs to the technical field of biological pharmacy and plasma immune globulin separation and purification. According to the method, horse source immune plasma is used as a raw material, enzymatic hydrolysate containing immune globulin F (ab ') 2 is obtained through protease enzymolysis, sodium caprylate is added to serve as a selective precipitator, non-target impure protein is selectively precipitated, and target protein F (ab') 2 is kept in the solution. After a clear feed liquid is obtained through solid-liquid separation, membrane separation or chromatographic purification treatment can be further carried out according to needs, and a horse-derived immunoglobulin F (ab ') 2 product is obtained. The precipitate formed by the invention is suitable for industrial filtration operation, solves the problems of low recovery rate of the existing ammonium sulfate precipitate and difficulty in filtration of the free octanoic acid precipitate, improves the feasibility and stability of the process, and improves the product recovery rate.

The invention discloses leg essence containing rutin, the leg essence is a double-phase essence, and the leg essence is composed of an oil phase and a water phase according to a weight ratio of (1-4): (2-7), the water phase is prepared from the following components in parts by weight: 0.01 to 1.5 parts of rutin liposome, 0.1 to 5 parts of grape vine extract, 0.1 to 3 parts of microcirculation dynamic factors, 0.1 to 4 parts of jania rubens extract, 0.5 to 1.5 parts of hexanediol, 0.5 to 0.8 part of p-hydroxyacetophenone, 1 to 8 parts of 1, 2-pentanediol, 0.2 to 1 part of thickening agent and the balance of water; the oil phase is prepared from the following components in parts by weight: 0.1 to 6 parts of abelmoschus manihot essential oil, 1 to 10 parts of plukenetia volubilis seed oil, 1 to 10 parts of pumpkin seed oil, 0.1 to 5 parts of zingiber zingiberensis extract, 0.1 to 3 parts of grapefruit essential oil, 20 to 50 parts of coconut oil alcohol-octoate / caprate, 20 to 40 parts of isopropyl myristate and 10 to 30 parts of squalane. The components in the formula supplement each other and have a synergistic effect, the conditions of leg edema and obesity are effectively improved, the water storage capacity of the skin is promoted, blood circulation and metabolism are promoted, and the oil is not greasy.