The invention discloses an atmospheric pressure atomization plasma efficient sterilization device, and a sterilization method. The main body structure of the atmospheric pressure atomization plasma efficient sterilization device comprises a high-voltage electrode, a grounding electrode, medium pipes, a fixed clamping groove, an insulating plate, a supporting plate, a distance adjusting rod, an atomization machine shell, a water inlet, a water inlet switch, an electricity inlet, a separation baffle plate, an ultrasonic atomizer, a mist outlet pipe, an outlet baffle plate and a machine shell cover plate. During an operation, a high-voltage wire and a ground wire are respectively led out from electrode lead-out ports at two ends and then are respectively connected with a high-voltage power supply and the ground, working liquid is introduced, then the power supply is turned on to generate plasma and preheat the device, the ultrasonic oscillator is started to generate water mist, the water mist is discharged through the mist outlet pipe below and enters an activation chamber, and the activated water mist can be directly used for object surface disinfection or space environment disinfection. The technology has the advantages that equipment is simple and portable, cost is low, and the generated atomized plasma is environmentally-friendly, efficient and free from pollution and chemical residues.