Antioxidant network efficacy nanoemulsion externally used for skin and preparation method thereof

An antioxidant and nanoemulsion technology, applied in skin care preparations, skin diseases, cosmetic preparations, etc., can solve the problem of low light stability, and achieve the effects of shortening the course of treatment, improving stability and improving efficacy

Active Publication Date: 2010-03-10
董萍 +1
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0042] In order to overcome the shortcoming that exists in the current background technology: (1) some functional components are not high to the stability of illumination

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0111] Implementation example:

[0112] (1) The optimal weight ratio of the raw materials of nanoemulsion with antioxidant effect for external use on skin is: vitamin E 1.0, glutathione 2.6, L-ascorbic acid-2-glucoside (AA2G) 2.5, seabuckthorn oil 1.1, coenzyme Q10 1.4, a-lipoic acid 0.5, isopropyl myristate 8.5, caprylic capric macrogolglyceride 23.7, polyglyceryl fatty acid ester 7.9, laurocaprone 0.7, triple distilled water 48.6, citric acid 0.2, sodium citrate 1.3 .

[0113] (2) Preparation of nanoemulsion with antioxidant effect for external skin application (taking 100g as an example)

[0114] ① Use an analytical balance to accurately weigh 0.2g of citric acid and 1.3g of sodium citrate and place them in a decontaminated 150mL Erlenmeyer flask, then add 48.6g of triple distilled water to fully dissolve, then add 2.5g of AA2G, dissolve and add 2.6g of glutathione, after mixing and dissolving evenly, clearly marked as the water phase (I) 55.2g with a colored marker, and ...

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Abstract

The invention relates to an antioxidant network efficacy nanoemulsion externally used for skin and a preparation method thereof. The nanoemulsion consists of the following raw materials according to weight mixture ratio: 1.0-1.5 of vitamin E, 2.0-3.0 of glutathione, 2.0-2.5 of L-ascorbic acid-2-heteroside, 1.0-1.8 of seabuckthorn oil, 1.0-1.6 of coenzyme Q10, 0.5-0.6 of alpha-lipoic acid, 8.0-10 of isopropyl myristate, 20-25 of caprylic acid capric acid polyethylene glycol glyceride, 7.0-9.0 of polyglyceryl fatty acid ester, 0.5-1.0 of azone, 46-50 of triple distilled water, 0.05-0.25 of citric acid and 1.0-1.6 of sodium citrate. The functional ingredients in the formula can form an antioxidant network system with cooperative interaction, synergy and regeneration, and the penetrating function of a nanoemulsion carrier system greatly enhances the antioxidant function and effect of the functional ingredients. The preparation method can enhance the stability and effectiveness of antioxidant, is simple in preparation technology and easy for scale production, needs no extra energy, saves time, energy and raw materials and is beneficial to environment protection.

Description

technical field [0001] The invention relates to an improved carrier technology of a novel transdermal delivery system applied to the formulation of anti-oxidation nanoemulsion products for external use on the skin, in particular to an anti-oxidation network effect nano-emulsion for external use on the skin and a preparation method thereof. Background technique [0002] Peroxidative damage is not only an important contributor to overall aging and disease, but also the greatest threat to skin aging and disease. Sun exposure, radiation, pressure, certain drugs, environmental pollution and many other factors can increase the free radicals in skin tissue, leading to skin aging, pigmentation, certain skin diseases, and even skin cancer. Therefore, no matter from the aspect of skin health and skin care, or the prevention of skin aging or diseases induced by free radicals, it is necessary to pay attention to strengthening and improving the antioxidant capacity of the skin. [0003]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/06A61K9/107A61Q19/00A61P17/18A61K8/67A61K8/64A61K8/49A61K8/35
Inventor 杨永鹏朱晓亮董萍丁宇夏林丁克祥
Owner 董萍
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