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A cosmetic or dermatological composition and its preparation method and application

A technology of dermatology and cosmetics, applied in the direction of cosmetic preparations, cosmetics, skin diseases, etc., can solve the problems of low bioavailability, poor skin absorption, low solubility, etc., and achieve the expansion of the gap between keratinocytes, uniform distribution, good compatibility

Active Publication Date: 2022-07-01
泉州达浔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, triterpene acids belong to drugs with low solubility and low permeability. For example, asiatic acid and ursolic acid belong to the fourth class of drugs according to the biopharmaceutics classification system BCS (biopharmaceutics classification system). They are insoluble in water and can be used in most solvents. Exhibits low solubility, making it low in cosmetic or dermatological preparations and has poor skin absorption and low bioavailability

Method used

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  • A cosmetic or dermatological composition and its preparation method and application
  • A cosmetic or dermatological composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] A composition in the form of an O / W nanoemulsion comprising the following components by weight of each raw material is,

[0079] Asiatic acid 0.5%

[0080] Madecassic acid 0.5%

[0081] Centella asiatica total glycosides 2%

[0082] Retinol 0.2%

[0083] Eucalyptus Essential Oil 2%

[0084] Tea tree oil 2%

[0085] Rosemary Essential Oil 1.2%

[0086] Diethylene glycol monoethyl ether (Transcutol) 8%

[0087] 1,2-Pentanediol 2%

[0088] Tween 20 16%

[0089] Polyoxyethylene 35 Castor Oil 12%

[0090] The balance is distilled water

[0091] Preparation:

[0092] ①Weigh the formula amounts of Eucalyptus essential oil, tea tree oil, rosemary essential oil, diethylene glycol monoethyl ether (Transcutol) and 1,2-pentanediol and add them to container A and mix well.

[0093] ② Take the formula amount of asiatic acid, madecassic acid, total asiaticoside, and retinol, add it to the mixture in container A, and stir until it is completely dissolved.

[0094] ③Add dist...

Embodiment 2

[0098] A composition in the form of an O / W nanoemulsion, comprising the following components by weight of each raw material:

[0099] Ursolic acid 1%

[0100] Centella Asiatica Extract 1%

[0101] Ginsenoside 1%

[0102] Retinol 0.1%

[0103] Eucalyptus Essential Oil 2%

[0104] Lemon Essential Oil 1.2%

[0105] Diethylene glycol monoethyl ether (Transcutol) 6%

[0106] 1,2 pentanediol 2%

[0107] Phenoxyethanol 0.3%

[0108] EDTA-2Na 0.2%

[0109] Sodium lactate 1%

[0110] Ceramide 0.2%

[0111] Dipotassium Glycyrrhizinate 0.5%

[0112] Poloxamer 188 0.6%

[0113] PEG-8 Caprylic / Capric Glycerides 10%

[0114] Polyoxyethylene 40 Hydrogenated Castor Oil 12%

[0115] Hydrogenated Lecithin 0.5%

[0116] The balance is distilled water

[0117] Preparation:

[0118] ①Weigh the eucalyptus essential oil, lemon essential oil, diethylene glycol monoethyl ether (Transcutol) and 1,2 pentanediol of the formula amount and add them in container A and mix well.

[0119] ② Tak...

Embodiment 3

[0124] The composition in the form of O / W nanoemulsion, including each raw material component in the following weight percentages is:

[0125] Asiatic acid 0.6

[0126] Centella asiatica total glycosides 1.5%

[0127] Oleuropein 1%

[0128] Ginsenosides 2%

[0129] Retinol 0.2%

[0130] Ursolic acid 0.1%

[0131] Eucalyptus Essential Oil 1.2%

[0132] Tea Tree Oil 1.2%

[0133] Lemon Essential Oil 0.6%

[0134] Dipropylene glycol 5%

[0135] 1,2 pentanediol 5%

[0136] Ascorbyl Glucoside 5%

[0137] Phenoxyethanol 0.2%

[0138] EDTA-4Na 0.2%

[0139] Sodium Hyaluronate 1%

[0140] Dipotassium Glycyrrhizinate 0.3%

[0141] Hexapeptide 0.5%

[0142] Sodium alginate 0.6%

[0143] PEG-6 Caprylic / Capric Glycerides 10%

[0144] Polyoxyethylene 40 Hydrogenated Castor Oil 8%

[0145] The balance is distilled water

[0146] Preparation:

[0147] ①Weigh the eucalyptus essential oil, tea tree essential oil, lemon essential oil, dipropylene glycol and 1,2 pentanediol in...

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Abstract

A cosmetic or dermatological composition and its preparation method and application belong to medicines and cosmetics. The composition comprises 0.001% to 10% of triterpene acids, 0% to 10% of triterpenoid saponins, 0% to 10% of vitamin A or vitamin A derivatives, 0.1% to 20% of essential oils containing terpenes, and 1% to 10% of emulsifiers. 40%, 1% to 40% of co-emulsifier, appropriate amount of water and additives; first dissolve triterpene acid, triterpene saponin and vitamin A or its derivatives in emulsifier, co-emulsifier and terpene-containing vegetable essential oil, while Disperse into the water phase while stirring, and obtain by high pressure homogenization. The prepared nanoemulsion is oil-in-water type, good water solubility, clear and translucent, good stability, high absorption efficiency, anti-aging, reducing wrinkles, whitening, suppressing acne, inhibiting seborrhea, inhibiting scar formation, promoting skin wound repair, etc. All are improved to a greater extent, and the preparation method is simple, and the application value of the composition in the field of medicine and cosmetics is improved.

Description

technical field [0001] The invention belongs to the technical field of medicine and cosmetics, and particularly relates to a cosmetic or dermatological composition and a preparation method and application thereof. Background technique [0002] With age, the activity of skin cell proliferation, collagen synthesis and skin hydration decreases. As a result, the skin looks dull, dry and flabby. With the acceleration of modern life rhythm and the increasing work pressure, overtime and staying up late, interference from physical factors and environmental factors, accelerate skin aging and relaxation. [0003] Terpenoids are olefinic compounds whose molecular formula is an integer multiple of isoprene (C5H8). They are lipids and are insoluble in water. Terpenes can be classified into monoterpenes, sesquiterpenes, diterpenes, triterpenes, etc., according to the number of isoprene units contained in the molecule. [0004] Triterpenoids are composed of several isoprenes linked end-...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/06A61K8/63A61K8/67A61K8/92A61K9/107A61K31/56A61K31/704A61K36/23A61K45/06A61P17/00A61Q19/00A61Q19/02A61Q19/08A61K31/07
CPCA61K8/63A61K8/922A61K8/671A61K8/9789A61K8/068A61Q19/00A61Q19/02A61Q19/08A61K45/06A61K31/56A61K31/704A61K31/07A61K36/23A61K9/1075A61P17/00A61K2800/5922A61K2800/82A61K2800/30A61K2800/782A61K2300/00
Inventor 林振放
Owner 泉州达浔生物科技有限公司
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