5 results about "MADECASSIC ACID" patented technology

The invention relates to the field of medical apparatuses and instruments, the field of medical or dressing preparations, the technical field of biological medicine manufacturing and the technical field of preparation manufacturing, in particular to an oil-soluble reverse micelle composition with anti-wrinkle and tightening effects and a preparation method and application of the oil-soluble reverse micelle composition. The composition comprises an active component, a yeast fermentation product, a stabilizer, grease and polyol, wherein the active ingredients comprise a centella asiatica extract, ginsenoside and aescin; the centella asiatica extract comprises asiaticoside, madecassic acid and asiatic acid; the yeast fermentation product comprises at least one of sophorolipid and rhamnolipid. The composition provided by the invention has good high-temperature stability and grease compatibility, is high in bioavailability and good in grease compatibility, and has obvious effects of resisting wrinkles, tightening, fading dark circles and improving vascular dark circles.

The present invention discloses synergistic herbal compositions comprising combination of a first ingredient selected from Centella asiatica extract containing at least one component selected from magnesium salt or complex of asiatic acid and magnesium salt or complex of madecassic acid or mixtures thereof along with asiaticoside and madecassoside; and a second ingredient selected from extract, fraction, phytochemical or mixtures thereof derived from Theobroma cacao; process for their preparation, methods of treatment and use of such nootropic compositions for improving cognitive functions or mental abilities and gaming performance.

The present invention belongs to the technical field of biomedicine. Disclosed is an asiatic-acid-derived ceramide, which has the structure of general formula (I) or an isomer of general formula I, wherein R1 is selected from one of the following structures in (II), and R2 is hydroxyl or a hydrogen atom. Further disclosed in the present invention are a method for synthesizing the asiatic-acid-derived ceramide and the use thereof. By means of the present invention, the solubility of ceramide is improved by means of introducing an asiatic acid or madecassic acid fragment with good fat solubility, thereby facilitating the use of ceramide in formulations. The compound of the present invention exhibits a significant inhibitory effect on inflammatory cytokine interleukin-6 (IL-6), and can also suppress the overexpression of TRPV1 receptors in sensitive skin and significantly reduce the expression of hyaluronidase, thereby achieving a good soothing effect.

The invention discloses a madecassoside efficient preparation method based on yeast metabolic engineering and a madecassoside compound cosmetic composition. Three glycosyl transferases CaGlcT1, CaGlcT2 and CaRhaT are screened from a centella asiatica transcriptome, after the catalytic activity of the glycosyl transferases is verified, polygene co-expression is performed in saccharomyces cerevisiae, and madecassic acid can be catalyzed to synthesize madecassoside. After fermentation condition optimization and fed-batch fermentation, the conversion yield of madecassoside reaches 582 mg / L from 165 mg / L, 3.5 times of yield increase is achieved, the purity of obtained madecassoside reaches 95% or above, and commercial application and scientific research requirements are met. The obtained madecassoside is compounded with the chrysanthellum indicum extract and the purslane herb extract, so that the synergistic anti-oxidation and whitening effects are achieved. A new scheme is provided for green and intelligent manufacturing of cosmetic raw materials.

The application provides a full-effect protection and prevention repair composition for acne skin and application thereof, and belongs to the technical field of cosmetics. The repair composition of the application is compounded with sulforaphane, lactoferrin, bromelain, madecassic acid lactone and guaiacum extract as active ingredients. The five substances can synergistically act together from multiple aspects, enhance the skin protection, improve the skin light damage, reduce the oxidative stress level, reduce the influence of stress hormone cortisol, and improve the emotional positivity, so as to achieve the effects of preventing acne, smoothing the skin and enhancing the barrier function.