14 results about "MADECASSIC ACID" patented technology

The invention belongs to the technical field of biological medicines, and discloses ceramide derived from asiatic acid, which has a structure shown in a general formula I or an isomer shown in the general formula I: # imgabs0, in which R1 is selected from one of the following structures: # imgabs1 # R2 is a hydroxyl group or a hydrogen atom. The invention further discloses a synthesis method and application of the ceramide derived from the asiatic acid, the asiatic acid or madecassic acid fragment with good fat solubility is introduced, the solubility of the ceramide is improved, and the ceramide is more convenient to apply in a formula; the compound disclosed by the invention has an obvious inhibiting effect on interleukin 6 (IL-6) inflammatory factors, can also inhibit the overexpression of a TRPV1 receptor of sensitive skin, and can obviously reduce the expression of hyaluronidase, so that the compound has a very good soothing effect.

The present invention relates to a highly soluble composition containing cosmetic actives, its preparation and application, belonging to the technical field of cosmetics. The highly soluble composition containing cosmetic actives of the present invention comprises cosmetic actives and a solvent; the cosmetic actives are selected from one or more of glycyrrhetinic acid, asiatic acid and madecassic acid; the solvent comprises hexylene glycol, methyl glucamine and water. Methyl glucamine has multiple hydroxyl groups in its structure and has good water solubility. By combining the amino group in its structure with the carboxyl group on the cosmetic actives, the hydrophilicity of the cosmetic actives is increased. Hexylene glycol has the characteristics of being amphiphilic for oil and water and can play a bridging role in dissolving the cosmetic actives, promoting the combination of the cosmetic actives and methyl glucamine, thus playing a synergistic effect. At the same time, the amount of solvent used can be greatly reduced, and the dissolution efficiency of the cosmetic actives can be greatly improved, thereby realizing the application value in cosmetics.

The present invention belongs to the field of plant genetic engineering technology, and in particular to the application of a Centella asiatica glycosyltransferase gene in catalyzing the glycosylation of asiatic acid and madecassic acid. The nucleotide sequence of the gene is as shown in SEQ ID No.1, and the protein encoded by it can catalyze the C-28 position of asiatic acid and madecassic acid to carry out glucose group modification to produce asiatic acid monoglucoside and madecassic acid monoglucoside, and prefers catalysis madecassic acid. The present invention, by building a metabolic regulatory network, widely and accurately screens the above-mentioned gene, resolves the glycosylation process of catalyzing asiatic acid and madecassic acid, for the in vitro synthesis of Centella asiatica triterpenoid saponins and industrial production process to improve asiatic acid and madecassic acid glycosylation efficiency and asiaticoside and madecassin yield provide important reference basis, and provide important theoretical support for large-scale production of Centella asiatica active saponins.

The invention discloses a composition with a skin barrier repairing effect as well as a preparation method and application thereof. The composition comprises carboxymethyl chitosan, ceramide and a centella asiatica extract, the mass ratio of the carboxymethyl chitosan to the ceramide to the centella asiatica extract is (0.01-5): (0.01-5): (0.01-5). The centella asiatica extract comprises one or a combination of more of madecassic acid, a centella asiatica root extract, asiaticoside and madecassoside, and the ceramide comprises one or a combination of more of ceramide NP, ceramide EOP, ceramide AS, ceramide AP, ceramide NS and ceramide NG. By implementing the invention, the skin barrier can be effectively repaired, the sensitivity can be relieved, and the moisturizing and nourishing effects can be realized.

The present invention relates to a cosmetic composition comprising a rose extract in the form of an isolated bioactive serum fraction, obtained from fresh roses of the Evanrat variety and a madecassic acid or an extract containing it, preferably an extract of Centella asiatica comprising asiaticoside, madecassic acid and asiatic acid, and its uses in particular to promote the barrier function and to prevent and / or reduce the signs of skin aging.

The present invention relates to a cosmetic composition comprising a rose extract in the form of an isolated bioactive serum fraction, obtained from fresh roses of the Evanrat variety and a madecassic acid or an extract containing it, preferably an extract of Centella asiatica comprising asiaticoside, madecassic acid and asiatic acid, and its uses in particular for promoting the barrier function and for preventing and / or reducing the signs of skin aging.

The invention relates to the field of detection of active ingredients of traditional Chinese medicines, in particular to application of dodder amine and / or 19 alpha-madecassic acid. According to the application disclosed by the invention, the osteoporosis resisting effect of the cuscutamine, the 19 alpha-hydroxyasitic acid in a mouse MC3T3-E1 cell and the osteoclast differentiation effect of the cuscutamine, the 19 alpha-hydroxyasitic acid in a mouse macrophage RAW 264.7 cell induced by sRANKL are evaluated by using osteoblast differentiation and mineralization. Experimental results show that in an osteoblast or osteoclast activity evaluation system, the cuscutamine, the 19 alpha-hydroxysidic acid has the anti-osteoporosis activity, and in addition, the cuscutamine, the 19 alpha-hydroxysidic acid has the anti-osteoporosis activity. Semen cuscutae amine and 19 alpha-madecassic acid can be used as anti-osteoporosis quality markers of the eight-component kidney tonifying capsules.

The invention relates to the field of medical apparatuses and instruments, the field of medical or dressing preparations, the technical field of biological medicine manufacturing and the technical field of preparation manufacturing, in particular to an oil-soluble reverse micelle composition with anti-wrinkle and tightening effects and a preparation method and application of the oil-soluble reverse micelle composition. The composition comprises an active component, a yeast fermentation product, a stabilizer, grease and polyol, wherein the active ingredients comprise a centella asiatica extract, ginsenoside and aescin; the centella asiatica extract comprises asiaticoside, madecassic acid and asiatic acid; the yeast fermentation product comprises at least one of sophorolipid and rhamnolipid. The composition provided by the invention has good high-temperature stability and grease compatibility, is high in bioavailability and good in grease compatibility, and has obvious effects of resisting wrinkles, tightening, fading dark circles and improving vascular dark circles.

The present invention discloses synergistic herbal compositions comprising combination of a first ingredient selected from Centella asiatica extract containing at least one component selected from magnesium salt or complex of asiatic acid and magnesium salt or complex of madecassic acid or mixtures thereof along with asiaticoside and madecassoside; and a second ingredient selected from extract, fraction, phytochemical or mixtures thereof derived from Theobroma cacao; process for their preparation, methods of treatment and use of such nootropic compositions for improving cognitive functions or mental abilities and gaming performance.

The present invention belongs to the technical field of biomedicine. Disclosed is an asiatic-acid-derived ceramide, which has the structure of general formula (I) or an isomer of general formula I, wherein R1 is selected from one of the following structures in (II), and R2 is hydroxyl or a hydrogen atom. Further disclosed in the present invention are a method for synthesizing the asiatic-acid-derived ceramide and the use thereof. By means of the present invention, the solubility of ceramide is improved by means of introducing an asiatic acid or madecassic acid fragment with good fat solubility, thereby facilitating the use of ceramide in formulations. The compound of the present invention exhibits a significant inhibitory effect on inflammatory cytokine interleukin-6 (IL-6), and can also suppress the overexpression of TRPV1 receptors in sensitive skin and significantly reduce the expression of hyaluronidase, thereby achieving a good soothing effect.

The present invention discloses an application of madecassic acid in antibacterial treatment, and belongs to the application field of effective ingredients of Chinese herbal medicine and natural compounds. The present invention systematically studies the antibacterial activity and related mechanisms of madecassic acid, and confirms that the antibacterial effect of madecassic acid on Gram-positive bacteria is better than that on Gram-negative bacteria, and the antibacterial effect on Staphylococcus aureus is the best. Through the experiment of combined use of madecassic acid and common β-lactam antibiotics, it is confirmed that madecassic acid and β-lactam antibiotics have a synergistic effect, and further evaluates the practical application of madecassic acid on the growth of MRSA bacteria in whole-fat high-temperature sterilized milk. The present invention systematically studies the antibacterial activity and related mechanisms of madecassic acid, which is helpful to develop its potential clinical medicinal value and edible value, and at the same time provides an important basis for the development of antibacterial drugs from Chinese herbal medicines and the formulation of clinical drug use specifications.

The invention discloses a madecassoside efficient preparation method based on yeast metabolic engineering and a madecassoside compound cosmetic composition. Three glycosyl transferases CaGlcT1, CaGlcT2 and CaRhaT are screened from a centella asiatica transcriptome, after the catalytic activity of the glycosyl transferases is verified, polygene co-expression is performed in saccharomyces cerevisiae, and madecassic acid can be catalyzed to synthesize madecassoside. After fermentation condition optimization and fed-batch fermentation, the conversion yield of madecassoside reaches 582 mg / L from 165 mg / L, 3.5 times of yield increase is achieved, the purity of obtained madecassoside reaches 95% or above, and commercial application and scientific research requirements are met. The obtained madecassoside is compounded with the chrysanthellum indicum extract and the purslane herb extract, so that the synergistic anti-oxidation and whitening effects are achieved. A new scheme is provided for green and intelligent manufacturing of cosmetic raw materials.

The application provides a full-effect protection and prevention repair composition for acne skin and application thereof, and belongs to the technical field of cosmetics. The repair composition of the application is compounded with sulforaphane, lactoferrin, bromelain, madecassic acid lactone and guaiacum extract as active ingredients. The five substances can synergistically act together from multiple aspects, enhance the skin protection, improve the skin light damage, reduce the oxidative stress level, reduce the influence of stress hormone cortisol, and improve the emotional positivity, so as to achieve the effects of preventing acne, smoothing the skin and enhancing the barrier function.

Disclosed is a synergistic herbal composition comprising: a first ingredient selected from an extract of centella asiatica, said extract containing at least one ingredient selected from the group consisting of a magnesium salt or complex of asiatic acid, a magnesium salt or complex of madecassic acid, or a mixture thereof, while also containing asiaticoside and madecassoside; a second component selected from the group consisting of an extract, fraction, phytochemicals of cocoa or mixtures thereof; the invention also discloses a preparation method and a treatment method of the composition, and application of the intelligence-improving composition to improvement of cognitive function or mental ability and game performance.