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New application of madecassic acid

A kind of madecassic acid, the technology of use, the application in the composition of madecassic acid or its derivatives and its isomers, the application in medicines or breast health care products, the field of madecassic acid or its derivatives, It can solve the problems of unreported anti-mammary gland hyperplasia effect of madecassolic acid and complex products, and achieve a good effect of breast hyperplasia

Inactive Publication Date: 2012-08-22
苏州迪星生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] And the composition of Asiaticoside is various, and the product of metabolism in vivo is complicated, and the effect of anti-mammary gland hyperplasia of madecassic acid has not been reported in the prior art

Method used

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  • New application of madecassic acid
  • New application of madecassic acid
  • New application of madecassic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 1. The effect of oral administration of madecassic acid and its salt on mammary gland hyperplasia in experimental rats

[0029] 【Test sample】

[0030] ① Madecassic acid (purity 92%), white powder. Accurately weigh madecassic acid, dissolve it with a small amount of ethanol, dilute with distilled water to a 0.5 mg / ml solution, and set aside.

[0031] ② Madecassic acid tromethamine salt (purity 93%), that is, ammonium madecassic acid formed by the carboxylic acid group in madecassic acid and 2-amino-2-hydroxymethyl-1,3-propanediol Butylene trioxide salt, white crystalline powder. Accurately weigh madecassate tromethamine salt, add distilled water to dilute to 0.6mg / ml solution, set aside.

[0032] 【experimental method】

[0033] Get female SD rats, intramuscularly inject 0.25 mg / kg / d of estradiol benzoate injection into legs for 25 consecutive days, and change to intramuscularly inject 5 mg / kg / d of progesterone injection for 5 consecutive days. Simultaneously with mod...

Embodiment 2

[0049] Madecassic acid sheet, its formula is: 50g of madecassic acid, starch 100g, lactose 50g, sodium carboxymethyl starch 10g, appropriate amount of magnesium stearate; Madecassic acid sheet is made 1000 by following process.

[0050] The preparation method is as follows: take madecassic acid powder, lactose, starch, and sodium carboxymethyl starch, pass through 80-mesh sieve respectively, weigh the above-mentioned main ingredients and auxiliary materials according to the prescription amount, mix them evenly, and use 70% ethanol to make soft materials, Granulate through a 24-mesh sieve, dry the wet granules in a ventilated oven at 50°C for 2.5 hours, granulate the dry granules with a 30-mesh sieve, add an appropriate amount of magnesium stearate and mix evenly; Put it on and get it.

Embodiment 3

[0052] Madecassic acid cream, its formula is: 20g of madecassic acid, 76.5g of cetyl alcohol, 150g of petrolatum, 60g of liquid paraffin, 8.5g of sodium lauryl sulfate, 50g of propylene glycol, a small amount of ethanol, ethyl paraben 1g, appropriate amount of water.

[0053] Its preparation method is: melt cetyl alcohol, vaseline, and liquid paraffin in a water bath at 80°C to obtain a co-melt M, dissolve sodium lauryl sulfate and ethylparaben in water, pour it into M, and obtain madecassic acid After dissolving with propylene glycol and a small amount of ethanol, add M, and stir until a homogeneous cream.

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Abstract

The invention relates to a new application of madecassic acid, derivatives, and isomers thereof, and particularly relates to an application of madecassic acid and derivatives thereof, or compositions of madecassic acid or its derivatives and its isomers in the preparation of medicaments for prevention and / or treatment of breast-related diseases, or breast health-care products. Studies confirm that both oral administration and external use of madecassic acid or derivatives thereof or compositions of madecassic acid or its derivatives and its isomers have significant inhibition effect on breast hyperplasia of experimental rats.

Description

technical field [0001] The present invention relates to the new field of application of madecassic acid and its derivatives, in particular to the field of madecassic acid or its derivatives, or the composition of madecassic acid or its derivatives and its isomers in the preparation of preventive and / or Or the application in the medicine of treating mammary gland hyperplasia or breast health products. Background technique [0002] Centella asiatica is the whole plant of Centella Asiatiea (L.) Urban, which is distributed in many countries and southern my country. The whole plant contains a variety of pentacyclic triterpenoid chemical components in the form of glycosides or aglycones. exist. The total glycosides extract of Centella asiatica is extracted and prepared from Centella asiatica, and its main components are asiaticoside, madecassoside, etc., which have the effect of promoting wound healing. Centella asiaticoside extract and the tablets and creams made from it have ob...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/56A61P15/14A23L1/30
Inventor 刘伦俊钱建兰阳山吴治军施亭
Owner 苏州迪星生物医药科技有限公司
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