Inhalation solution preparation containing Centella asiatica active ingredients and preparation method of inhalation solution preparation

Abstract

The invention belongs to the field of pharmaceutics, and particularly relates to an inhalation solution preparation containing Centella asiatica active ingredients and a preparation method of the inhalation solution preparation. The solution preparation includes 1 [mu]g / mL-30 mg / mL of Centella asiatica active ingredients, an isotonic agent and a solvent, wherein the Centella asiatica active ingredients are one or more selected from Centella asiatica total asiaticosides, asiaticoside, madecassoside, asiaticoside B, asiatic acid, pharmaceutical salts of asiatic acid, madecassic acid, pharmaceutical salts of madecassic acid, asiatic acid B and pharmaceutical salts of asiatic acid B. The solution preparation has clear pharmaceutical effects and low content of impurities, the active ingredientsof Centella asiatica have good stability during long-term storage, and the content of main ingredients reaches 98% or above; the inhalation solution preparation has clear pharmaceutical effects, highstability, reliable quality, high safety and long storage time, and moreover, no preservatives are added to the solution preparation, so that the safety factor of the solution preparation is higher;and the solution preparation has suitable taste, and the taste of the active ingredients of Centella asiatica is covered fully.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a solution preparation of active ingredients of Centella asiatica for inhalation and a preparation method thereof. Background technique [0002] Pulmonary fibrosis is the end-stage change of a large class of lung diseases characterized by fibroblast proliferation and accumulation of a large amount of extracellular matrix, accompanied by inflammatory damage and tissue structure destruction, that is, normal alveolar tissue is damaged and undergoes abnormal repair to lead to structural changes. Abnormal (scarring). Pulmonary fibrosis seriously affects the respiratory function of the human body, manifested as dry cough and progressive dyspnea (perceived insufficient gas), and with the aggravation of the disease and lung damage, the patient's respiratory function continues to deteriorate. The morbidity and mortality of idiopathic pulmonary fibrosis are increasing year by year. The...

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Problems solved by technology

[0004] At present, most of the drugs clinically used to treat pulmonary fibrosis are taken orally, and oral preparations have the disadvantages of low bioavailability and poor therapeutic effect. In order to change this situation, we pioneered the active ingredient in Centella asiatica Prepared into an aerosolized inhalation preparation, which can greatly improve the bioavailability of the drug and improve the therapeutic effect through pulmonary administration, and at the same time provide a new treatment idea for the treatment of fibrosis

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