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Application of madecassic acid in preparation of medicine for preventing or treating ulcerative colitis

A technology of madecassic acid and ulcerative colitis, which is applied in the field of medicine, can solve the problems of no research on the biological activity or application of madecassic acid in anti-ulcerative colitis, so as to improve the therapeutic effect and quality of life, Low toxicity and side effects on human body, and the effect of reducing the general score

Pending Publication Date: 2021-03-05
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] So far, there is no research on the biological activity or application of madecassic acid against ulcerative colitis

Method used

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  • Application of madecassic acid in preparation of medicine for preventing or treating ulcerative colitis
  • Application of madecassic acid in preparation of medicine for preventing or treating ulcerative colitis
  • Application of madecassic acid in preparation of medicine for preventing or treating ulcerative colitis

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Embodiment Construction

[0016] In order for those skilled in the art to fully understand the present invention, the present invention is further described through specific examples below, but those skilled in the art should know that the present invention is not limited in any way by the examples of the present invention. The present invention proves through experiments that the salt of madecassate and the complex of madecassic acid can also achieve similar technical effects.

[0017] Embodiment The effect of madecassic acid on the curative effect of rats with ulcerative colitis

[0018] 1. Grouping and administration of animals

[0019] Fifty-two SPF grade SD rats, half male and half male, weighing 150-170 g.

[0020] Refer to Jiang Xueliang et al. (Jiang Xueliang, Quan Qizhen, Wang Dong, et al. Establishment of ulcerative colitis model in rats by compound method[J]. Journal of Qinghai Medical University, 1999, 20(4): 1-3) to establish ulcerative colitis model Inflammation (UC) model, rats were fe...

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Abstract

The invention discloses application of madecassic acid, or a salt thereof, or a complex thereof in preparation of a medicine for preventing or treating ulcerative colitis, and belongs to the field ofmedicines. Animal experiments show that the madecassic acid has a remarkable prevention and treatment effect on ulcerative colitis. The madecassic acid has an exact effect of resisting ulcerative colitis, is low in side effect, and has a wide medical application prospect.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a medical application of madecassic acid, in particular to the medical application of madecassic acid in the preparation of drugs for preventing or treating ulcerative colitis. Background technique [0002] Centella asiatica (Centella asiatica (L.) Urban) is a centella asiatica tree plant in the family Umbelliferae. Centella asiatica has a long history of application in the field of traditional medicine in many countries and regions. The internal and external use of Centella asiatica in traditional Chinese medicine in my country has a history of two thousand years, and it was first recorded in the book "Shen Nong's Herbal Classic". The chemical constituents of Centella asiatica mainly include triterpenoids, flavonoids, polyynenes and volatile oils. Triterpenoids mainly include triterpenoid saponins, such as madecassoside, madecassoside, etc., and triterpenoid acids, such as asiatic acid, ma...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K36/23A61P1/00A61P1/04
CPCA61K31/56A61K36/23A61P1/00A61P1/04
Inventor 张贵民齐长鹏宁停波
Owner LUNAN PHARMA GROUP CORPORATION
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