Method for preparing total asiatic acid, asiatic acid and madecassic acid from asiatic pennywort herb and use of prepared product

A technology of madecassoic acid and madecassoic acid is applied in the directions of drug combinations, pharmaceutical formulations, steroids, etc., which can solve the problems of time-consuming and labor-intensive, solvent consumption, inability to prepare madecassoside at the same time, etc. Low cost, good for promotion

Inactive Publication Date: 2011-03-30
SHANGHAI NORMAL UNIVERSITY
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Problems solved by technology

[0003] The active ingredients of Centella asiatica are total saponins of Centella asiatica, Asiatic acid, and Madecassic acid. At present, the preparation method of Asiatic acid and Madecassic acid is mainly extracted directly from Centella asiatica grass. The content of asiatic acid and hydroxyasiatic acid in grass is very low, so it needs to go through tedious separation and purification processes such as extraction and chromatography to obtain, which is time-consuming and laborious, and consumes a lot of solvents
It has been reported that asiatic acid was prepared from asiaticoside to increase the yield of asiatic acid, but this method uses asiaticoside as a raw material and cannot simultaneously prepare madecassoside

Method used

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  • Method for preparing total asiatic acid, asiatic acid and madecassic acid from asiatic pennywort herb and use of prepared product
  • Method for preparing total asiatic acid, asiatic acid and madecassic acid from asiatic pennywort herb and use of prepared product

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Embodiment 1

[0022] The present invention is further described below:

[0023] Extraction of Centella asiatica total saponins:

[0024] Whole grass coarse powder 1Kg, add 10 liters of water to reflux and extract three times, each time for 1.5 hours, filter, combine the filtrate, concentrate under reduced pressure to a specific gravity of 1.1, add three times the volume of 95% alcohol for precipitation, leave overnight, filter, and decompress the filtrate Concentrate to dryness to obtain 51g, which is the total saponins of Centella asiatica, with a yield of 5.1%.

[0025] Also use 1 kg of whole herb coarse powder, add 10 liters of 60% alcohol to reflux and extract three times, each time for 1.5 hours, the following operations are the same as above, and 56 g of total saponins are obtained, with a yield of 5.6%.

[0026] Preparation of Centella asiatic acid:

[0027] Add 51g of the above-mentioned total saponins of Centella asiatica, add 200ml of 1% potassium hydroxide solution, heat and st...

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Abstract

The invention relates to a method for preparing total asiatic acid, asiatic acid and madecassic acid from asiatic pennywort herb and use of a prepared product. The method comprises the following steps of: preparing asiaticoside from coarse powder of the asiatic pennywort herb; treating the asiaticoside by using alkali liquor, acidifying, extracting by using n-butyl alcohol, and recrystallizing byusing alcohol to prepare the total asiatic acid; and performing chromatography on the total asiatic acid to obtain the asiatic acid and the madecassic acid. Meanwhile, the total asiatic acid, the asiatic acid and the madecassic acid can be used for reducing postmeal glucose and preventing and treating diabetes. The method has the characteristics that the process is simple, the cost is low, and the method is suitable for promotion and large-scale production.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of traditional Chinese medicines, and in particular relates to a method for preparing total asiatic acid, asiatic acid and hydroxyasiatic acid from centella asiatica and the application of the obtained preparation. Background technique [0002] Centella asiatica is a commonly used traditional Chinese medicine recorded in the Chinese Pharmacopoeia. It is the whole herb of the Umbelliferae plant Centella asiatica Linn. The Liver, Spleen, and Kidney meridians have the effects of clearing away heat and promoting dampness, detoxifying and reducing swelling. Used for damp-heat jaundice, heatstroke diarrhea, sand and blood, carbuncle sores, traumatic injuries. In recent years, studies have reported that Centella asiatica has the functions of promoting wound healing, softening scars, anti-psoriasis, anti-depression, anti-mammary gland hyperplasia, anti-liver fibrosis, anti-cancer, tre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/23A61P3/10C07J63/00A61K31/56
Inventor 宋纯清叶晓平茅仁刚
Owner SHANGHAI NORMAL UNIVERSITY
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