Use of madecassic acid of centella asiatica in preparing medicaments for treating liver fibrosis

A technology of asiatic acid and hepatic fibrosis, applied in the field of Centella asiatica, can solve problems such as hindering the application of Centella asiatica and unclear effects, and achieve the effect of widening choices, less adverse side effects, and good curative effect

Inactive Publication Date: 2013-03-20
HANGZHOU SHARPLY PHARM R&D INSTIT +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Centella asiatica contains a variety of components, and it is not clear which components play a role in the prevention and treatment of liver fibrosis and cirrhosis, which greatly hinders the application of Centella asiatica in the treatment of liver fibrosis and cirrhosis

Method used

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  • Use of madecassic acid of centella asiatica in preparing medicaments for treating liver fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1: Preparation of madecasinolic acid injection:

[0039] Take 100ml of Tween 20, put it in a 1000ml measuring bottle, add 10g of madecassoic acid, shake until completely dissolved, add pH 7.0 phosphate buffer solution (PBS) to the mark, mix well and put it on a water bath at 50°C for heating 30min. Leave it for 6 hours until the solution system is balanced, and pass it through a 0.45 μm filter membrane to make madecassoic acid injection.

Embodiment 2

[0040] Example 2: Preparation of madecasinolic acid injection:

[0041] Take 60ml of Tween 20 and 40ml of Tween 85, put them in a 1000ml measuring bottle, add 6g of madecasinolic acid, shake until completely dissolved, add pH 7.0 phosphate buffer solution (PBS) to the mark, mix well and put in Heat on a water bath at 50°C for 30 minutes. Leave it for 6 hours until the solution system is balanced, and pass it through a 0.45 μm filter membrane to make madecassoic acid injection.

Embodiment 3

[0042] Example 3: Preparation of madecassoic acid injection:

[0043] Take 80ml of Tween 20 and 20ml of Tween 85, put them in a 1000ml measuring bottle, add 14g of madecasinolic acid, shake until completely dissolved, add pH 7.0 phosphate buffer solution (PBS) to the mark, mix well and put in Heat on a water bath at 50°C for 30 minutes. Leave it for 6 hours until the solution system is balanced, and pass it through a 0.45 μm filter membrane to make madecassoic acid injection.

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PUM

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Abstract

The present invention relates to the use of centella asiatica, and in particular relates to the use of monomer madecassic acid of the centella asiatica in preparing medicaments for treating liver fibrosis. The present invention also provides madecassic acid injection for the treatment of liver fibrosis and preparation method thereof. The present invention effectively broadens choices of liver fibrosis and cirrhosis patients, and compared with existing medicaments for treating liver fibrosis, the products of the present invention has the advantages of good efficacy, and little adverse side effect.

Description

technical field [0001] The present invention relates to the use of Centella asiatica, especially the use of Centella asiatica in the preparation of medicines for treating liver fibrosis, in particular the use of madecasinolic acid in the preparation of medicines for treating liver fibrosis. Background technique [0002] Liver fibrosis is a pathological state of abnormal hyperplasia of fibrous connective tissue in the liver, and it is an inevitable stage in the development of chronic liver disease to cirrhosis. Hepatic stellate cells (Hsc) are activated through paracrine action to oversynthesize and secrete extracellular matrix (ECM), pro-inflammatory and fibrotic cytokines due to liver cell injury. With the development of liver lesions, liver cells degeneration, necrosis, regenerative nodules, pseudolobules and fibrous septa are formed, and the normal structure of the liver is destroyed. As a result, the liver hardens (cirrhosis) and can further develop into liver cancer. W...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7024A61P1/16
Inventor 范敏华魏巍周学来
Owner HANGZHOU SHARPLY PHARM R&D INSTIT
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