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Madecassic acid solid lipid nanoparticle gel

A nanotechnology of madecassic acid and solid lipids, which is applied in the field of medicine, can solve the problems of low skin penetration and drug utilization, large molecular weight, and low water solubility, and achieve improved keratinization function and good biocompatibility , the effect of avoiding liver damage

Pending Publication Date: 2020-11-13
CHANGSHA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The triterpenoid saponin component mademasiatic acid (madasiatic acid, MA) is one of the most important active ingredients in Centella asiatica. Some studies have compared mademasiatic acid, asiatic acid, madecassoside, centella asiatica The inhibitory effects of 8 saponins such as total glycosides and asiaticoside on the proliferation of scar fibroblasts showed that the activity of madecassic acid and asiatic acid was far stronger than that of other compounds, and madecassic acid It is stronger than asiatic acid, indicating that the inhibitory effect of aglycone is stronger than that of glycosides. It has 1. Anti-inflammatory: anti-irritation 2. True skin repair: inhibit collagen synthesis, 3. Surface skin repair: improve keratinization function, 4. Anti-inflammatory Aging: Stimulate skin cells and other effects, but limited by the low water solubility and large molecular weight of madecassic acid, resulting in low skin penetration and drug availability

Method used

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  • Madecassic acid solid lipid nanoparticle gel
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  • Madecassic acid solid lipid nanoparticle gel

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preparation example Construction

[0044] Preferably, the preparation method of the Asiatic Hydroxy Acid Solid Lipid Nanoparticle Gel comprises:

[0045] (1) After mixing glyceryl behenate and soybean phospholipid, heat and melt in a water bath at 85-95°C;

[0046] (2) After adding madecassic acid to absolute ethanol and ultrasonically dissolving it, adding it to the molten liquid of step (1), heating and melting in a water bath at 85-95°C to form an oil phase;

[0047] (3) Disperse the surfactant in water, heat and melt in a water bath at 85-95°C to form a water phase;

[0048] (4) Slowly add the oil phase to the water phase under stirring at a constant temperature of magnetic force of 1000r / min and stir for 40min. After mixing evenly, shear at 13000r / min for 2-5min to form colostrum;

[0049] (5) Prepare the colostrum into Asiatic acid solid lipid nanoparticles by solvent emulsification volatilization-high pressure homogenization method;

[0050] (6) Take carbomer 940 and water in a weight ratio of 1:7.5-12.5 and mix an...

Embodiment 1

[0057] (1) After mixing 300 g of glyceryl behenate and 150 g of soybean phospholipid, heat and melt in a water bath at 85°C;

[0058] (2) After adding 150 g of madecassic acid to 6 g of absolute ethanol to ultrasonically dissolve it, adding it to the molten liquid of step (1), heating and melting in a water bath at 85° C. to form an oil phase;

[0059] (3) Disperse 750g of surfactant (the ratio of Tween-80 and Poloxamer 188 is 1:0.5) in water, heat and melt in a water bath at 85°C and mix uniformly to form an aqueous phase;

[0060] (4) Slowly add the oil phase to the water phase under stirring at a constant temperature of magnetic force of 1000r / min and stir for 40min, mix well and shear at 13000r / min for 2min to form colostrum;

[0061] (5) Prepare the colostrum into Asiatic acid solid lipid nanoparticles by solvent emulsification volatilization-high pressure homogenization method;

[0062] (6) Take carbomer 940 and water in a weight ratio of 1:7.5 and mix and swell for 24h. Add 0.8ml...

Embodiment 2

[0066] (1) After mixing 300 g of glyceryl behenate and 150 g of soybean phospholipids, heat and melt in a water bath at 90°C;

[0067] (2) After adding 220 g of madeasiatic acid to 8.8 g of absolute ethanol to dissolve it ultrasonically, add it to the molten liquid of step (1), and heat and melt in a water bath at 90° C. to form an oil phase;

[0068] (3) Disperse 1000 g of surfactant (the ratio of Tween-80 and Poloxamer 188 is 1:1) in water, heat and melt in a water bath at 90°C and mix uniformly to form an aqueous phase;

[0069] (4) Slowly add the oil phase to the water phase under stirring at a constant temperature of magnetic force of 1000r / min and stir for 40min, mix well and shear at 13000r / min for 3min to form colostrum;

[0070] (5) Prepare the colostrum into Asiatic acid solid lipid nanoparticles by solvent emulsification volatilization-high pressure homogenization method;

[0071] (6) Take carbomer 940 and water in a weight ratio of 1:10 and mix for 24h, add 0.8ml of ethanol ...

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Abstract

The invention discloses a madecassic acid solid lipid nanoparticle gel. The madecassic acid solid lipid nanoparticle gel comprises madecassic acid solid lipid nanoparticles and blank gel, wherein theweight part ratio of the madecassic acid solid lipid nanoparticles to the blank gel is 25: 19, and the madecassic acid solid lipid nanoparticle gel has the effects of resisting inflammation and irritation, repairing true skin, inhibiting collagen synthesis, repairing surface skin, improving the keratinization function, resisting aging, stimulating skin cells and the like; through skin administration, the damage to the liver is avoided, the percutaneous penetration amount and bioavailability of the medicine are improved, and the purpose of sustained and controlled release targeted administration is achieved.

Description

Technical field [0001] The invention relates to the technical field of medicine, in particular to a solid lipid nanoparticle gel of Asiatic hydroxyacid. Background technique [0002] Centella asiatica, also known as Bengdawan, Luodeda, Xianqian, Copper Money Grass, Half-side Money, etc. It is a plant of the Centella genus Umbelliferae (Umbelliferae). It is a perennial herb with creeping stems, slender, and upper knots. root. The whole plant of this product mainly contains triterpene saponins (such as asiaticoside, madecassoside, etc.) and triterpene acids (asiatic acid, asiatic acid, asiatic acid, etc.), volatile oil Ene, farnesene, elemene, etc.), flavonoids (quercetin, quercetin-3-glucoside, etc.), etc., which can clear away heat and detoxify, reduce swelling, inhibit scar hyperplasia, regulate immune cells, diuresis, Anti-cancer, anti-bacterial, anti-ulcer, anti-atherosclerosis and other effects. [0003] The triterpene saponins, madasiatic acid (MA) is one of the most import...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/51A61K31/56A61K47/24A61K47/14A61K47/32A61P17/00A61P17/18A61P29/00
CPCA61K31/56A61K9/06A61K9/5123A61K47/32A61P29/00A61P17/00A61P17/18
Inventor 马宁彭祎婧
Owner CHANGSHA MEDICAL UNIV
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