Freezing-dried and non-freezing-dried hydroquinone mono-propionate beautifying effect nanometer emulsion and preparation method thereof

Abstract

The invention relates to a freeze-dried or non-freeze-dried hydroquinone monopropionate beauty effect nanoemulsion and a preparation method thereof. The freeze-dried nanoemulsion of the present invention is made of the following raw materials in parts by weight: hydroquinone monopropionate 0.5-4.0, vitamin E 0.2-2.0, isopropyl myristate 8-16, caprylic capric acid tri Glyceride 0.1-1.0, caprylic capric acid polyethylene glycol glyceride 32-40, polyglycerol fatty acid ester 10-14, double distilled water 35-45, mannitol 15-25, glycine 1-6. The non-lyophilized nanoemulsion is made of the following raw materials in parts by weight: hydroquinone monopropionate 0.5-4.0, vitamin E 0.2-2.0, isopropyl myristate 8-16, caprylic capric triglyceride 0.1-1.0, caprylic capric acid polyethylene glycol glyceride 32-40, polyglycerol fatty acid ester 10-14, double distilled water 35-45. The preparation process of the invention is simple, the actual operation is easy, no special equipment is needed, the preparation is efficient and fast, and the entire completion time is less than 30 minutes, it is easy to be industrialized, the product quality is stable, the storage time is prolonged, and it saves energy and raw materials and reduces environmental pollution. There has also been considerable progress.

Description

technical field [0001] The present invention relates to the preparation of biopharmaceutical preparation technology applied to skin pigmented diseases and cosmetic whitening and spot-removing products after improvement, in particular to a freeze-dried and non-freeze-dried hydroquinone monopropionate beauty effect nanoemulsion and its preparation method. Background technique [0002] With the development of society, the advancement of science and technology, and the continuous improvement of people's material, cultural, and spiritual living standards, beauty care is not only the pursuit of all beauty lovers, but also an important part of people's pursuit of high-quality and high-grade life in modern society. Among them, skin whitening and freckle removal have become the focus of beauty and health care cosmetics. [0003] Yet a kind of beauty care cosmetics for skin whitening and freckle removal not only must be safe and have no side effects and make the skin feel comfortable...

AI Technical Summary

Problems solved by technology

[0015] However, at present, there are also some problems in the actual application of nanoemulsions: in the current cosmetic cosmetics for the treatment of skin pigmentation diseases and skin whitening and freckle removal, hydroquinone monopropionate has been successfully compounded into freeze-dried or non- The application of freeze-dried nanoemulsion is still blank; the preparation technology of successful freeze-dried or non-lyophilized hydroquinone monopropionate skin cosmetic effect nanometer is also blank; how to choose less toxic emulsifiers and co-emulsifiers with hydrogen Quinone monopropionate matching to reduce toxicity and skin irritation of lyophilized or non-lyophilized hydroquinone monopropionate nanoemulsions; how to reduce the amount of emulsifier and co-emulsifier; how to determine the best matching emulsifier and Co-emulsifier to improve the stability and antioxidant properties of hydroquinone monopropionate nanoemulsion; how to determine the best formula and preparation process of freeze-dried or non-lyophilized hydroquinone monopropionate skin cosmetic nanoemulsion; how to use Freeze-dried or non-freeze-dried hydroquinone monopropionate skin beauty nanoemulsions have better whitening and anti-freckle effects and advantages; how to choose and determine the types and application doses of active ingredients in skin whitening and anti-freckle beauty nanoemulsions Concentration, etc. are unsolved puzzles