11results about How to "Achieve long-term effect" patented technology

The invention relates to a preparation method and application of a wall coating type enzyme-loaded microchannel reactor. The method comprises the following steps: mixing tetramethyl orthosilicate, methyltrimethoxysilane and methanol to obtain a solution A; deionized water, polyethylene glycol, a sodium fluoride aqueous solution and a dialyzed lipase solution are mixed to obtain a solution B, the solution B and the solution B are mixed for 3-10 minutes in an ice bath environment to obtain a solution C, the solution C is introduced into the pretreated microchannel through an injection pump, after incubation is conducted for 10-60 minutes, nitrogen is adopted for purging, redundant sol-gel is removed, and then the solution C is put into a drying oven to be dried; the catalyst is used for hydrolysis reaction of grease and various ester exchange and esterification reactions. The method can be carried out in a mild environment, and has higher conversion rate and shorter reaction time.

The invention discloses a coupling drug of albumin binding peptide fused with a single-domain antibody and a preparation method and application thereof, and relates to the technical field of biological pharmacy, the coupling drug is obtained by fusing albumin binding peptide and the single-domain antibody to obtain fusion protein and coupling drug molecules with the fusion protein; the fusion form of the albumin binding peptide and the single-domain antibody comprises a single-target monoclonal antibody mode: the C terminal or the N terminal of the albumin binding peptide is fused with one single-domain antibody; in the single-target double-antibody mode, the C end and the N end of the albumin binding peptide are simultaneously fused with one single-domain antibody or are respectively fused with two same single-domain antibodies; and a double-target double-antibody mode: the C end and the N end of the albumin binding peptide are respectively fused with two different single-domain antibodies. By means of the characteristic of high-affinity binding of the albumin binding peptide and the serum albumin, the long-acting effect of the coupling medicine in vivo can be achieved, the effect that the coupling medicine is enriched to a tumor part in vivo in a targeted mode can be achieved, and the anti-tumor purpose is achieved.

The invention provides a fruit growth regulator and bacteriostatic preservative as well as a preparation method and application thereof, and belongs to the technical field of preservation, pomace is taken as a raw material, and pomace microfibrillated cellulose, pectin and seed oil containing phenolic substances are extracted through organic acid treatment, DES reagent auxiliary mechanical treatment, ethanol water treatment and other treatments; then carrying out hydroformylation modification on nano cellulose, grafting chitosan, and compounding with pectin to obtain dialdehyde microfibrillated cellulose-chitosan-pectin composite particles with pH response performance, and taking the dialdehyde microfibrillated cellulose-chitosan-pectin composite particles as a stabilizer of a Pickering emulsion; the green growth regulator solution is used as a continuous phase, the seed oil mixed Chinese herbal medicine extract is used as a dispersion phase, the controlled-release Pickering emulsion with growth regulation and bacteriostasis effects is prepared, the prepared emulsion is sprayed on berries to form a film layer, the growth process of the berries can be regulated, the fruit yield and quality are improved, and the quality of the berries is improved. And antibacterial substances can be slowly released for preservation when berries are picked and stored.

This invention relates to the field of water remediation technology, specifically to a piezoelectric catalytic component and a groundwater remediation system. The piezoelectric catalytic component includes: an upper part of a piezoelectric catalytic body with a spiral channel communicating with an inlet, and a lower part with a cavity; the cross-sectional diameter of the spiral channel gradually decreases from the inlet to the end; a column is provided in the cavity, and a piezoelectric film is spirally wound around the column; the end of the spiral channel is close to the piezoelectric film at the upper end of the column; the piezoelectric film receives water containing organic pollutants flowing in from the spiral channel and catalytically degrades the organic pollutants through piezoelectric conversion; this application combines the static pressure of the water flow, accelerates the water flow through the spiral channel, the flow velocity gradually increases from top to bottom, the hydraulic impact load is correspondingly enhanced, the mechanical force flowing through the piezoelectric film is increased, low-frequency vibration excites the piezoelectric catalytic effect, maximizes the catalytic degradation capacity of the piezoelectric material, and thus improves the catalytic degradation efficiency of the piezoelectric material.

The application discloses an antistatic agent, a pressure-sensitive adhesive and application thereof, and belongs to the technical field of protective films. The antistatic agent is prepared by copolymerization of the following monomers in parts by weight: 15-25 parts of a quaternary ammonium salt monomer, 20-30 parts of a first acrylate soft monomer, 3-8 parts of a first acrylate hard monomer and 1-5 parts of a hydroxyl-containing monomer. The antistatic agent is a quaternary ammonium salt acrylate copolymer prepared by copolymerization of the quaternary ammonium salt monomer, the acrylate soft monomer, the acrylate hard monomer and the hydroxyl-containing monomer. The copolymer has both a quaternary ammonium salt conductive group and an acrylate group. The acrylate group can deeply participate in photopolymerization, so that the quaternary ammonium salt group with a conductive function is firmly anchored on the adhesive copolymer molecular chain through a covalent bond, thereby effectively solving the migration and precipitation problems of the antistatic component and realizing long-acting antistatic performance.

This invention discloses an artesunate prodrug, its preparation method, and its application. The artesunate prodrug comprises amphiphilic polymer groups with different functions coupled to a 1,3,5-triazine-2,4,6-triamine or cyanuric chloride backbone molecule as shown in formula (I). The amphiphilic polymer groups are hydrophilic polyethylene glycol derivative groups containing terminal amino or carboxyl groups and artesunate groups. This artesunate prodrug can self-assemble into long-acting liposomes in water, showing potential for treating neutrophilic asthma.

The present application belongs to the technical field of functional materials, and particularly relates to a coated carbon nanotube composite material and a preparation method thereof, and a functional polymer composite material and a preparation method thereof. The coated carbon nanotube composite material provided by the present application has a core-shell-shell structure coated in turn from inside to outside, wherein the carbon nanotube constitutes an inner core providing mechanical enhancement and an electrically conductive path, a silver layer coated on the surface of the carbon nanotube serves as an intermediate layer and a first antibacterial component, a copper oxide nanoparticle layer coated on the surface of the silver layer serves as an outer shell layer and a second antibacterial component, and the copper oxide layer and the silver layer form a heterojunction. The specific structure produces a synergistic effect of silver, copper oxide and carbon nanotube, so that the composite powder has the functions of high-efficiency antibiosis, antistatic and mechanical enhancement.

According to the fouling release type marine antifouling paint with the underwater bonding effect, firm bonding of a cured coating is achieved through the low-hydration hydrogen-bond interaction formed by a thiourea group and a base material or intermediate paint, and in the seawater environment, a hydrogen-bond network formed by the hydrophobic thiourea group generates the dehydration effect, so that the long-acting bonding effect is achieved. The influence of seawater on the cohesion of the coating is reduced to the greatest extent due to the introduction of the sulfydryl group, so that the coordination between the cohesion and the adhesive force of the cured coating is ensured, and the effective adhesion of the coating is realized. And the surface of the cured coating still shows the characteristic of low surface energy, so that the adhesion of fouling organisms is effectively inhibited. The coating can be applied to the field of antifouling of marine facilities, and is particularly suitable for various marine facilities immersed in a seawater environment for a long time.

This invention discloses a micro-space TCM-adaptive planning and AI self-learning control method based on holistic health care in the home environment, involving the fields of family health care and intelligent environmental control technology. The method includes the following steps: S1, Initialization and Record Building: The user inputs and stores the physical condition test reports of all family members and the distribution map of the family's micro-spaces into the system. This micro-space TCM-adaptive planning and AI self-learning control method based on holistic health care in the home environment deeply integrates TCM constitution theory with family micro-space planning. Through TCM constitution record building, it clarifies the basic constitution, chronic diseases, and allergens of family members, and marks and divides each micro-space in the home according to its location, function, lighting, and ventilation. This achieves TCM-adaptive planning of the micro-spaces. Simultaneously, it matches specific environmental parameters for each space according to different constitutions, upgrading family environmental control from physical parameter adjustment to personalized adaptation to meet the needs of human health care.

The invention discloses amphiphilic polyurethane-organic silicon resin based on dynamic disulfide bonds and nano hybridization and a preparation method of the amphiphilic polyurethane-organic silicon resin. According to the invention, through prepolymerization of hydrophilic hydroxyl polyether and diisocyanate, dynamic disulfide bond chain extension, copolymerization of hydroxyalkyl polysiloxane and compounding of nano silicon dioxide, resin with an amphiphilic micro-area, a dynamic reversible cross-linked network and an organic-inorganic hybrid structure is constructed. The resin has excellent mechanical toughness, efficient self-repairing capability and lasting long-acting antifouling property, is particularly suitable for marine antifouling paint, can be self-repaired after being damaged, and remarkably improves the durability and the service life of a coating in a harsh marine environment.

The invention provides an oral implant abutment with gingival healing promoting and immunoregulation effects and a preparation method thereof, and belongs to the technical field of novel oral implants.The problem that the implant-gingival interface sealing performance is poor is solved.The preparation method comprises the steps that 1, pure titanium is selected to be processed into the abutment, and cleaning and drying are conducted; 2, synthesizing a polydopamine mediated coating on the surface of the abutment processed in the step 1; step 3, constructing a (3-trimethoxy) propyl 2-bromo-2-methyl propionate initiator coating on the surface of the abutment obtained in the step 2; step 4, constructing a PSBMA-PEG polymer coating on the surface of the abutment obtained in the step 3; and step 5, constructing a PSBMA-PEG-LDP coating on the surface of the abutment obtained in the step 4. The functional group of PSBMA-PEG is covalently connected with LDP to form a stable PSBMA-PEG-LDP specific coating on the surface of the implant abutment, so that the long-acting effect of LDP on the implant abutment-gingival interface is realized, and a new hope is brought to effective combination of the implant abutment and gingiva.