The invention belongs to the field of medicinal preparations and a novel medical technology and relates to an in situ
gel preparation loaded with Kangfuxin and its preparation method and use. The in situ
gel preparation loaded with Kangfuxin has temperature sensibility. The in situ
gel preparation loaded with Kangfuxin is characterized in that Kangfuxin as a
raw material and polymers are dissolved in a
buffer solution or
purified water according to a ratio. Because of
polymer reverse-phase gel properties, the in situ gel preparation loaded with Kangfuxin is in a
liquid state and can freely flow at a
room temperature (of 20 DEG C) under storage conditions, and when the in situ gel preparation loaded with Kangfuxin is spread on a wound, under the action of a body temperature, the in situ gel preparation loaded with Kangfuxin forms fast semi-
solid gel. The in situ gel preparation loaded with Kangfuxin is convenient for patient use, improves
patient compliance, can effectively store drugs and can slowly release drugs so that
drug action time is prolonged and
drug efficacy is improved. Through
oral administration, the in situ gel preparation loaded with Kangfuxin can be used for treating
blood stasis, stomachache, gastrorrhagia, gastric ulcer and
duodenal ulcer and assistantly treating
Yin deficiency and
pulmonary tuberculosis, and phthisis. Through external administration, the in situ gel preparation loaded with Kangfuxin can be used for treatment and anti-adhesion of
metal-inflicted wounds, trauma wounds, ulcer wounds,
fistula wounds, burn wounds, scald wounds, bedsore wounds and surgical wounds.