The invention relates to an axial circular pipe type screen heat pipe taking copper oxide nanoparticle suspension as working substance, which consists of an evaporation section, a thermal insulation section and a cooling section, wherein, the thermal insulation section is externally covered with a Teflon stick to make thermal insulation, the cooling section is externally welded with a cooling water jacket, the inner wall of the evaporation section is provided with a screen liquid-absorbing core structure, the working substance filled inside the screen liquid-absorbing core structure is copper oxide nanoparticle suspension, and the fluid filling rate is 40 to 60 percent of the volume of the evaporation section. The copper oxide nanoparticle suspension is the mixing liquid of de-ionized water and copper oxide nanoparticles, and the mass concentration of the copper oxide nanoparticles in the suspension is between 0.5 and 2 percent. During the use, the element which needs to make a heat radiation is pasted on the lower end of the heat pipe, the heat of the element which needs to make a heat radiation is transferred to the cooling section depend on the evaporation heat transfer of the working substance inside the grooved heat pipe, the working substance in the cooling section condenses the heat transfer to transfer the heat into condensed water. After the invention uses the water based copper oxide nanoparticle suspension as the working substance, the heat exchange performance is improved, and the total heat resistance of the heat pipe is decreased.