Porous nickel-copper oxide nanowire array enzyme-free glucose sensor electrode on titanium substrate

A glucose sensor and porous nanowire technology, applied in the field of enzyme-free glucose sensor electrodes, can solve the problems of expensive glucose oxidase, poor electrochemical performance, and difficult storage, and achieve the effects of low cost, fast response, and low limit

Inactive Publication Date: 2012-06-20
HUAZHONG NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because glucose oxidase is expensive and difficult to store, it must be refrigerated at low temperature and easily inactivated. If it is not stored properly, glucose oxidase will lose its catalytic activity and lose the function of glucose concentration detection. Therefore, this electrode is cheap, convenient and widely used. Just exist the difficulty that is difficult to overcome; Simultaneously, the chitosan of immobilizing glucose oxidase or Nafion all has the property of being slightly soluble in water, so, the glucose oxidase that plays electrochemical reaction will slow down along with chitosan or Nafion. Slowly soluble in water, that is, long-term or multiple use, the glucose oxidase on the electrode will become less and less, and its electrochemical performance will become worse and worse

Method used

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  • Porous nickel-copper oxide nanowire array enzyme-free glucose sensor electrode on titanium substrate
  • Porous nickel-copper oxide nanowire array enzyme-free glucose sensor electrode on titanium substrate
  • Porous nickel-copper oxide nanowire array enzyme-free glucose sensor electrode on titanium substrate

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Experimental program
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Effect test

Embodiment 1

[0034] Precursor (Ni, Cu) 2 (OH) 2 CO 3 Preparation of nanowire arrays: clean titanium metal sheet (3×2×0.03cm 3 ) into 0.32 grams of copper chloride dihydrate (CuCl 2 2H 2 O), 0.24 grams of nickel chloride hexahydrate (NiCl 2 ·6H 2 O) and 0.7 gram of urea in 80 milliliters of aqueous solutions; Then seal and heat to 120 ℃ in the autoclave of polytetrafluoroethylene liner, keep 24 hours; After natural cooling, titanium metal sheet is taken out, obtains the precursor of electrode sample (Ni, Cu) 2 (OH) 2 CO 3 Nanowire Array Films. The samples were observed by scanning electron microscope and X-ray diffraction. The results show that the precursor (Ni, Cu) 2 (OH) 2 CO 3 The nanowires are distributed vertically, uniformly and densely on the surface of the titanium metal sheet, presenting a nanowire array structure. The diameter of the top of a single nanowire is 20 nanometers, and the length is 2 microns. The results are shown in figure 1 and figure 2 .

Embodiment 2

[0036] The precursor (Ni, Cu) on the titanium substrate 2 (OH) 2 CO 3 The nanowire array film was placed in a box furnace at 350° C. for 60 minutes and annealed to obtain a porous nanowire array film with NiO / CuO nanoparticles cross-assembled on the titanium substrate. Then the morphology and crystal structure of the samples were observed by scanning electron microscope, transmission electron microscope and X-ray diffractometer. The result is expressed in image 3 , Figure 4 and Figure 5 middle. It can be seen from the figure that the nanowire array basically maintains the state before annealing, but the single nanowire has become a porous structure. The nanowires are cross-assembled by NiO and CuO nanoparticles, and the size of the nanoparticles and nanopores are both 5 nm. The X-ray diffraction results of the samples annealed at 350℃ show that the annealing temperature is lower and the crystallization state of the samples is poor.

Embodiment 3

[0038] The precursor (Ni, Cu) on the titanium substrate 2 (OH) 2 CO 3 The nanowire array film was annealed in a box furnace at 500°C for 60 minutes to obtain a porous nanowire array film with cross-assembled NiO and CuO nanoparticles on the titanium substrate. Then the morphology and crystal structure of the samples were observed by scanning electron microscope, transmission electron microscope and X-ray diffractometer. The result is expressed in Figure 6 , Figure 7 and Figure 8 middle. It can be seen from the figure that the nanowire array basically maintains the state before annealing, but the single nanowire has become a porous structure. The nanowires are cross-assembled by NiO and CuO nanoparticles, and the size of the nanoparticles and nanopores are both 5 nm. The X-ray diffraction results of the samples annealed at 500°C show that the higher the annealing temperature, the better the crystalline state of the samples.

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Abstract

The invention relates to a porous nickel-copper oxide nanowire array enzyme-free glucose sensor electrode on a titanium substrate. The electrode is of a porous nanowire array structure formed by alternately assembling nickel-copper oxide nanoparticles on the titanium substrate, wherein single nanowire has the top-end diameter of 20+ / -1 nm and the length of 2+ / -0.2 mu m; the nanowires are vertically, uniformly and compactly distributed on the surface of titanium metal so as to form an array; the single nanowire is formed by alternately assembling copper oxide and nickel oxide nanoparticles with particle size of 5+ / -0.2 nm; and nanopores with size of 5+ / -0.2 nm are uniformly distributed in the nanowires. The preparation method comprises the steps of: placing a clean titanium metal sheet in an aqueous solution of copper chloride dihydrate, nickel chloride hexahydrate and urea, sealing and heating in an autoclave with polytetrafluoroethylene inner lining to 120 DEG C and maintaining for 24 hours; naturally cooling, and taking out the titanium metal sheet to obtain a precursor (Ni,Cu)2(OH)2CO3 nanowire array film of an electrode sample; and respectively annealing the precursor sample in air at 350 DEG C and 500 DEG C to obtain the sensor electrode. The obtained electrode can be applied to biological, medical, electronic instruments and other products.

Description

technical field [0001] The invention relates to an enzyme-free glucose sensor electrode, in particular to a porous nanowire array non-enzyme glucose sensor electrode composed of overlapping nickel-copper oxide nanoparticles on a titanium substrate. It belongs to the fields of biology, medicine, analytical chemistry, electronic equipment, electronic information, etc., and is mainly used in electrochemical analysis instruments of biology, clinical medicine, chemistry, chemical industry and other products. Background technique [0002] On the ordinary electrochemical glucose detection electrode, it is necessary to use chitosan or Nafion to immobilize the glucose oxidase that plays an electrochemical reaction on the electrode. Because glucose oxidase is expensive and difficult to store, it must be refrigerated at low temperature and easily inactivated. If it is not stored properly, glucose oxidase will lose its catalytic activity and lose the function of glucose concentration de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/327
Inventor 黄新堂丁瑞敏刘金平
Owner HUAZHONG NORMAL UNIV
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