31 results about "Behenic acid" patented technology

Edible, pourable, fat-containing product, preferably in the form of a water-in-oil emulsion or a full fat product, comprising 40 to 99.9 wt. % liquid vegetable oil; 0.1 to 10 wt. % of hard stock fat; water up to 100 wt. %, wt. % calculated on the total weight of the product, wherein the hard stock fat is free from palm or palm-derived fats or fat fractions; free from hydrogenated fats or fat fractions and has a C22:0 (behenic acid) content of at least 10 wt. %, wt. % calculated on the amount of fatty acids in the hard stock.

The technical problem of the present invention is to provide an oily food which does not solidify even in a cold storage temperature range, is flexible, does not bleed out even in contact with a food containing moisture, and has a good gloss and flavor in appearance. According to the present invention, by satisfying all of the following conditions (a) to (e), it is found that an oily food which is flexible in a cold storage temperature range, does not bleed out, and has a good gloss and flavor in appearance can be provided: (a) a saturated fatty acid having 16 to 24 carbon atoms is contained in an oil content of the oily food in a total amount of 15 to 33 mass%; (b) an unsaturated fatty acid having 18 carbon atoms is contained in the oil content of the oily food in a total amount of 60-90 mass%; (c) less than 3% by mass of moisture; (d) an oil content of 35-70% by mass; and (e) 0.1-2 mass% of a glycerin fatty acid ester containing 40 mass% or more of behenic acid in the oily food.

Gummy or jelly candies with modified functional ingredients with controlled time-release. The invention relates to gummy or jelly candies (1) comprising at least one modified functional ingredient with controlled time-release, characterized in that they comprise, inside or on the surface, at least one modified functional ingredient (2), namely encapsulated and / or granulated, said gummy or jelly candies having the following constituents: at least one carbohydrate consisting of glucose syrup and / or sugar; at least one fiber; at least one protein; and at least one fruit in the form of concentrated juice or natural juice and / or at least one natural or artificial sweetener; at least one gelling agent; at least one flavoring; at least one coloring; said at least one modified functional ingredient which is a food functional ingredient; water;and at least one acid, the constituent (E) comprising an active substance or a functional ingredient proper (3) and an excipient, and being disposed of in capsules or granules (4), the excipient being a microencapsulation excipient in the case of capsules or a granulation excipient in the case of granules, said excipient being at least one of: glyceryl dibehenate, hydroxypropyl cellulose and / or ethyl cellulose, a constituent (E) having an excipient proportion of between 20 and 80% by weight.;

The present invention discloses a hair metabolite marker combination for diagnosing Alzheimer's disease and its application. The hair metabolite marker combination includes triacontanes, erucic acid, heneicosane, behenic acid, tetracosane, 3-hydroxybutyric acid, 15-methylhexadecanoic acid, arachidic acid, heptadecanoic acid, melatonin, stearic acid, tetracosanoic acid, heneicosanoic acid, and docosane. The present invention uses metabolomics methods to study, compare, and analyze the hair metabolites of AD patients, MCI patients, and cognitively normal subjects, explores potential biomarkers that may be contained therein, obtains a group of hair metabolite differences among AD patients, and evaluates the sensitivity and specificity of this group of substances for diagnosing AD. The present invention provides a new marker for the accurate diagnosis of AD and can be used in clinical auxiliary diagnosis of AD to improve diagnostic accuracy.

Provided are compositions that include colchicine conjugated to behenic acid, optionally wherein the colchicine conjugated to behenic acid is encapsulated by a nanoliposome. In some embodiments, the colchicine is conjugated to behenic acid at the acetamide position of a B-ring of colchicine, the nanoliposome includes a lipid component comprising DSPC, DOPE, and DSPE-PEG, and cholesterol; and / or the colchicine conjugated to behenic acid is present in the nanoliposome in an amount of at least about 400, 500, 600, or more than 600 pg / mL. Also provided are methods for preparing behenic acid-conjugated colchicine derivatives, methods for preparing lipid nanoparticle-encapsulated colchicine derivatives, and methods for using the same to treat and / or prevent inflammatory and / or cardiovascular diseases, disorders, and / or conditions.

Disclosed is a compound essential oil for improving dull skin, which comprises the following components: oleic acid, linoleic acid, palmitic acid, stearic acid, limonene, α-pinene, linalool, palmitoleic acid, eicosanoic acid, squalene, α-copaene, cis-11-eicosenoic acid, β-pinene, trans-caryophyllene, 3-thujene, camphene, behenic acid, myristic acid, p-cymene, (+)-δ-cadinene, menthol, linolenic acid, caprylic acid, menthone, capric acid, sabinene, and myrcene. The compound essential oil has excellent effects of skin whitening, brightening, and moistening.

To provide a method which enables powdery food to be easily dispersed in water.SOLUTION: A method for improving water dispersibility of powdery food comprises including a powder of a propylene glycol fatty acid ester in a powdery food in a powder state, the ester containing stearic acid or behenic acid as the constituent fatty acid. The ester is not particularly limited as long as it is a solid at room temperature and can be processed into a powder. However, there may be mentioned, for example, a monoester or a mixture of a monoester and a diester, with the monoester being preferable.SELECTED DRAWING: None

Compound essential oil for alleviating skin aging and a preparation method therefor. The compound essential oil comprises the following components in parts by weight: 60-70 parts of oleic acid, 10-20 parts of linoleic acid, 10-20 parts of palmitic acid, 1-10 parts of stearic acid, 0.1-0.8 parts of cis-11-eicosenoic acid, 0.1-0.8 parts of α-copaene, 0.1-0.6 parts of linolenic acid, 0.1-0.5 parts of α-pinene, 0.1-0.5 parts of trans-caryophyllene, 0.1-0.5 parts of eicosanoic acid, 0.1-0.4 parts of linalool, 0.01-0.4 parts of (+)-δ-cadinene, 0.01-0.3 parts of limonene, 0.01-0.3 parts of behenic acid, 0.01-0.3 parts of palmitoleic acid, 0.01-0.3 parts of β-cedrene, 0.01-0.2 parts of tetracosanoic acid, 0.01-0.2 parts of β-pinene, 0.01-0.1 parts of 3-thujene, 0.01-0.1 parts of myristic acid, 0.01-0.1 parts of α-humulene, 0.01-0.1 parts of (-)-α-gurjunene, 0.01-0.1 parts of α-cedrene, and 0.01-0.1 parts of p-cymene. The compound essential oil is derived from natural and green raw materials, can effectively avoid side effects while treating skin aging, and thus has good safety.

The invention discloses an encapsulated oil-in-water type composition and a preparation method thereof. The encapsulated oil-in-water type composition comprises the following components in percentage by weight: 0.1-1% of retinol; the oil-phase thickening agent is selected from one or more of dextrin palmitate, a castor oil / IPDI (isophorone diisocyanate) copolymer, an HDI (hexamethylene diisocyanate) / trihydroxymethyl hexyl lactone cross-linked polymer, glyceryl behenate, a hydrogenated (styrene / butadiene) copolymer and dibutyl lauroyl glutamine; the oil-phase thickening agent is selected from one or more of dextrin palmitate, a castor oil / IPDI (isophorone diisocyanate) copolymer, an HDI (hexamethylene diisocyanate) / trihydroxymethyl hexyl lactone cross-linked polymer, glyceryl behenate, a hydrogenated (styrene / butadiene) copolymer and dibutyl lauroyl glutamine; 10%-20% of an oil component, wherein the oil component comprises caprylic acid / capric triglyceride; 0.1%-5% of a rheology modifier; 5-20% of a humectant; and the balance of water. The capsule product has good slow release property. According to the composition disclosed by the invention, high-content addition and high-efficacy performance of the retinol are realized, meanwhile, good formula stability can also be realized, and the problem of skin irritation caused by the retinol is improved.

The use of renewable energy to reduce fossil fuel consumption is a key strategy to mitigate pollution and climate change, resulting in the growing demand for new sources. Fast-growing proprietary cyanobacterial strains of Fremyella diplosiphon with an average life cycle of 7-10 days, and a proven capacity to generate lipids for biofuel production were studied. We investigated the growth and photosynthetic pigmentation of a cyanobacterial strain (SF33) in both greenhouse and outdoor bioreactors and produced biocrude via hydrothermal liquefaction. The cultivation of F. diplosiphon did not significantly differ under suboptimal conditions (p<0.05), including in outdoor bioreactors with growth differences of less than 0.04 (p=0.035) among various batches. An analysis of the biocrude's components revealed the presence of fatty acid biodiesel precursors such as palmitic acid and behenic acid, and alkanes such as hexadecane and heptadecane, used as biofuel additives. In addition, the quantification of value-added photosynthetic pigments revealed chlorophyll a and phycocyanin concentrations of 0.0011±5.83×10−5 μg / μL and 7.051±0.067 μg / μg chlorophyll a. Our results suggest the potential of F. diplosiphon as a robust species that can grow at varying temperatures ranging from 13° C. to 32° C., while producing compounds for applications ranging from biofuel to nutritional supplements. This paves the way for production-level scale-up and processing of F. diplosiphon-derived biofuels and marketable bioproducts. Fuel produced using this technology will be eco-friendly and cost-effective and will make full use of the geographical location of regions with access to brackish waters.

To provide a cleansing agent that smoothly blends with the skin, exhibits good compatibility with makeup, and enables excellent moisture retention after rinsing.SOLUTION: A cleansing agent comprising the following components (A) to (D): (A) 50 mass% or more and 80 mass% or less in total of hydrocarbon oil and ester oil, (B) 1 mass% or more and 20 mass% or less of polyhydric alcohol, (C) a mixed ester of (poly)glycerin, behenic acid, and eicosanedioic acid, and (D) 0.01 mass% or more and less than 1 mass% of a nonionic surfactant having an HLB of 12 or higher.SELECTED DRAWING: None

The invention provides high-purity aluminum oxide nano powder and a preparation method thereof, and belongs to the technical field of nano material preparation. The preparation method comprises the following steps: by taking aluminum sulfate octadecahydrate and aluminum chloride hexahydrate as aluminum salts and polyethylene glycol and fumaric acid as admixtures, slowly adding an aluminum salt solution into an ammonium carbonate solution to react, washing, centrifuging, filtering, drying and sieving to obtain precursor powder, adding ethanol into the precursor powder to prepare slurry, then adding behenic acid into the slurry, and carrying out ball milling to obtain a finished product. And carrying out ball milling, sieving, drying and calcining to obtain the high-purity aluminum oxide nano powder. The prepared aluminum oxide nano powder is uniform in particle size distribution and good in dispersity, the purity is larger than 99.99%, and the requirement of the high-end aluminum oxide nano powder industry can be met.

The invention discloses a tin-free weather-resistant hydroxyl polyester resin and a preparation method thereof, and belongs to the technical field of hydroxyl polyester resin, the preparation method comprises the following steps: firstly, carrying out acid pickling and calcining pretreatment on diatomite, then carrying out KH-550 silane coupling agent modification, cerium loading and behenic acid hydrophobic modification to obtain a cerium-loaded hydrophobic modified diatomite catalytic promoter, and finally, carrying out acid pickling and calcining treatment on the cerium-loaded hydrophobic modified diatomite catalytic promoter to obtain the tin-free weather-resistant hydroxyl polyester resin. Then taking polybasic acid and polyhydric alcohol as monomers, adding an ethylene glycol titanium catalyst and a hydrolysis-resistant catalytic promoter, and performing normal-pressure esterification and high-vacuum polycondensation reaction to prepare the tin-free weather-resistant hydroxyl polyester resin; on the basis of tin-free treatment, through synergistic catalysis of the ethylene glycol titanium catalyst and the cerium-loaded hydrophobic modified diatomite catalytic promoter and structural optimization of the rigid monomer, the technical problems that a traditional titanium catalyst is poor in low-temperature dispersity and prone to hydrolysis and deactivation in advance are effectively solved, the stability of a catalytic system and the processing performance of resin are improved, and the service life of the resin is prolonged. The weather-resistant polyester resin is suitable for weather-resistant polyester resin scenes for powder coatings such as high-end outdoor building materials and automobile hubs.

To provide an oily cosmetic having superior ability to give moisturized sensation and smoothness to hair, and also having superior spreadability and hair setting ability.SOLUTION: An oily cosmetic comprising the following components (A) to (C): (A) an oil-soluble polyurethane, (B) glyceryl behenate / eicosanedioate and / or glyceryl tribehenate / isostearate / eicosanedioate, and (C) a liquid oil.SELECTED DRAWING: None

The present invention aims to provide an oily food product that remains soft without solidifying even at refrigerated temperatures, does not seep through when in contact with foods containing moisture, and has a good glossy appearance and flavor. [Solution] The present invention provides, (a) The total amount of saturated fatty acids with 16 to 24 carbon atoms in the oil of oily foods is 15 to 33% by mass. (b) Linoleic acid makes up 20-40% by mass of the oil content in oily foods. (c) The moisture content is less than 3% by mass. (d) The oil content is 35-70% by mass. (e) A glycerin fatty acid ester containing 40% or more by mass of behenic acid is contained in an oily food product at a concentration of 0.1 to 2% by mass. By satisfying all of the conditions (a) to (e), we found that it is possible to provide an oily food product that remains soft at refrigerated temperatures, does not ooze, and has a good appearance, gloss, and flavor.

The invention provides a low-odor and easy-to-demould polypropylene material for automobiles and a preparation method thereof, and belongs to the technical field of high polymer materials. The polypropylene material comprises the following components in parts by weight: 60-80 parts of polypropylene, 0-8 parts of an ethylene-octylene copolymer (POE), 16-25 parts of talcum powder, 1-2 parts of a deodorant, 1-2 parts of a coupling agent, 0.1-0.2 part of an antioxidant, 0.2-0.4 part of a dispersing agent, 0.3 part of a heat stabilizer and 0.2-0.5 part of a release agent, and behenamide (Hubeheng Xing Constant Industry 3061-75-4) is selected as the release agent. Through model selection of the specific release agent and synergistic cooperation of all the components, on the basis that the mechanical property of the material is guaranteed, the double advantages of low odor and easy demolding are achieved, the problems that a traditional release agent is easy to decompose, the odor exceeds the standard and demolding is poor are effectively solved, and the release agent is suitable for production of automobile interior trim parts of complex structures; the preparation method is simple in process, easy in parameter control and convenient for industrial popularization.

The invention discloses compound essential oil for improving varicosity and a preparation method of the compound essential oil. Comprising the following components: oleic acid, linoleic acid, octanoic acid, decanoic acid, limonene, palmitic acid, alpha-pinene, stearic acid, beta-pinene, gamma-terpinene, 3-cacumen biotae, p-cymene, menthol, menthone, 3-carene, linalool, docosanoic acid, myrcene, sabinene, trans-caryophyllene, isomenthone, citronellol, pulemenone, 4-terpinenol and eudesmol. The compound essential oil disclosed by the invention has excellent effects of improving leg vascular protrusion, obviously improving bluish violet, and relieving soreness and swelling, pain and itching of an affected part.

The present invention provides an iron-based mixed powder for powder metallurgy, which contains an iron-based powder and one or more binders that are selected from the group consisting of oleic acid amide, erucic acid amide, lauric acid amide, palmitic acid amide, stearic acid amide, behenic acid amide, and ethylene bis-oleic acid amide, have a melting point of 60°C to 120°C inclusive, and adhere to the surface of the iron-based powder, wherein the content of the binders with respect to the mass that is obtained by subtracting the mass of the binders from the total mass of the iron-based mixed powder for powder metallurgy is 0.01 mass% to 1.0 mass% inclusive. According to the present invention, the powder compact strength of an iron-based green compact that is obtained by pressure molding the iron-based mixed powder for powder metallurgy is increased, and damage to the iron-based green compact in green processing can be prevented. In addition, the energy consumption required for heating and mixing of an iron-based mixed powder for powder metallurgy can be reduced.

The invention provides a preparation method of printing ink and a product thereof. A differentiated resin method is adopted, so that the color mixing resistance of the bottom covering ink and the color ink is improved; titanium dioxide is treated by pentaerythritol, so that the anti-settling stability of the bottom-covering ink is remarkably improved, and the spraying stability is improved; by screening and combining pigments with different hue angles, the hue angle difference delta h degree of the ink combination is reduced, and the color gamut volume is increased; through a mixed solvent of N-methyl-2-pyrrolidone and n-octylbenzene, the concentration and the stability of the graphene dispersion liquid are improved, and the friction resistance and the stability of the ink are further improved; and behenic acid is adopted for treatment, so that the friction resistance of the ink is improved.

The present invention relates to an oily food in combination with a moisture-containing food, a method for producing the same, a food, and a method for improving the gloss of an oily food in contact with a moisture-containing food. According to the present invention, it is found that by satisfying all of the following conditions (a) to (e), an oily food can be provided which is flexible in a cold storage temperature range, does not bleed out, and has a good gloss and flavor in appearance, (a) the total amount of saturated fatty acids having 16 to 24 carbon atoms, which are constituent fatty acids in the oil content of the oily food, is 15 to 33 mass%, and (b) the total amount of saturated fatty acids having 16 to 24 carbon atoms, which are constituent fatty acids in the oil content of the oily food, is 15 to 33 mass%. (b) 20-40 mass% of linoleic acid as a constituent fatty acid in the oil content of the oily food; (c) less than 3% by mass of moisture; (d) an oil content of 35-70% by mass; and (e) 0.1-2 mass% of a glycerin fatty acid ester containing 40 mass% or more of behenic acid in the oily food.

The invention discloses a method for efficiently preparing arachidic acid and behenic acid by adsorbing and decontaminating raw materials through bio-based calcium oxide, and relates to the field of grease chemical engineering, the method comprises the following steps: S1, high-erucic acid rapeseed oil raw materials are subjected to decontaminating treatment through an adsorption column filled with bio-based calcium oxide, and the bio-based calcium oxide is prepared by calcining aquatic organism shells; s2, carrying out acidic hydrolysis on the impurity-removed raw material to obtain mixed fatty acid; according to the method for efficiently preparing the arachidic acid and the behenic acid by adsorbing and removing impurities from the raw materials through the bio-based calcium oxide, the bio-based calcium oxide is prepared from waste shells, high-value utilization of waste is achieved, and the cost is low. The material has a high specific surface area and abundant mesopores, and shows a selective adsorption capacity far higher than that of common calcium oxide on polar impurities such as thioglycoside and colloid, the removal rate can reach 88% or above, and the purity of the raw materials is guaranteed from the source.

The application belongs to the technical field of cosmetics, and discloses a portulaca oleracea seed oil, a preparation method and application thereof, cosmetics, medicines and food. The portulaca oleracea seed oil comprises, in percentage by mass, 33-37% of linoleic acid, 24-27% of linolenic acid, 15-18% of oleic acid, 14-16% of palmitic acid, 3.5-4.5% of stearic acid, 0.5-1% of isooleic acid and 0.3-0.4% of behenic acid. The portulaca oleracea seed oil prepared by the preparation method of the application can effectively promote the proliferation of immortalized keratinocytes, reduce the production of inflammatory factors, has strong anti-inflammatory effect, can promote the expression of filaggrin and tight junction protein genes and has barrier repair effect. The preparation method of the portulaca oleracea seed oil comprises sequentially drying, seed oil extraction, seed oil purification, decolorization, impurity removal and drying to obtain the portulaca oleracea seed oil, and has the advantages of simple operation, high yield, low cost, stable product quality, green and environment-friendly process and suitability for large-scale production.

The present invention belongs to the technical field of genetic engineering, and particularly relates to a gma‑miR287 , a recombinant overexpression vector and its application in regulating the fatty acid content of plants. The gma‑miR287 has a nucleotide sequence as shown in SEQ ID NO.1. The present invention screens and successfully clones the differentially expressed fatty acid-related gene gma‑miR287 . The present invention introduces gma‑miR287 into plants to obtain plants overexpressing gma‑ miR287 . The plants show a decrease in the contents of palmitic acid, oleic acid, linoleic acid and eicosenoic acid, and an increase in the contents of palmitoleic acid, linolenic acid, eicosenoic acid, behenic acid and erucic acid. By regulating the gma‑miR287 expression in plants, the present invention is used to cultivate new plant varieties with regulable fatty acid content, providing ideas for cultivating new varieties and having great application value in molecular breeding.

The present invention belongs to the field of biomedicine technology. It is a ceramide compound as shown in the chemical formula I: #imgabs0# wherein R 1 A residue selected from α-linolenic acid, γ-linolenic acid, eicosapentaenoic acid, docosahexaenoic acid, arachidonic acid, ximenynic acid, azelaic acid, jasmonic acid, threonic acid, 4-aminobutyric acid, erucic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, lactobionic acid, rosmarinic acid, danshensu, sodium 3-(4-hydroxy-3-methoxyphenyl) lactate, p-hydroxyphenylacetic acid, palmitoleic acid, vitamin B5, vitamin H, ricinoleic acid, behenic acid, cis-11-eicosenoic acid, hexacosenoic acid-cis-17-enoic acid, cis-11,14-eicosadienoic acid, mandelic acid, or a condensation residue of a fruit acid, R 2 Select one of the following structures: -C 15 H 29 ,‑C 15 H 31 ,‑C 15 H 27 , ‑CHOHC 14 H 27 , ‑CHOHC 14 H 29 The present invention reacts a functional carboxylic acid with a sphingoid base to obtain a class of ceramide compounds with novel structures, thereby enhancing the original efficacy of such molecules and improving the physical and chemical properties of the ceramide compounds.

The present invention aims to provide a non-bleeding chocolate-like food product that offers excellent workability at room temperature. [Solution] The present invention provides, (a) The total amount of saturated fatty acids with 12 and 14 carbon atoms in the constituent fatty acids of the oil contained is 20 to 48% by mass. (b) The total amount of unsaturated fatty acids with 18 carbon atoms in the constituent fatty acids of the oil contained is 37-59% by mass. (c) The moisture content is less than 3% by mass. (d) The oil content is 35-70% by mass. (e) Contains 0.5 to 2% by mass of glycerin fatty acid ester containing 40% by mass or more of behenic acid. By satisfying all of the conditions (a) to (e), we found that it is possible to provide a chocolate-like food product that is easy to work with and does not bleed at room temperature.

The application discloses a time-controlled thermal trigger hydrophobic capsule and a preparation method thereof. The capsule comprises a hydrophobic active substance, a thermal response matrix and a selective additive component. The hydrophobic active substance accounts for 30%-70% of the total mass of the capsule and comprises one or more of stearic acid, behenic acid or long-chain alkyl silane. The thermal response matrix is a waxy material with a melting point of 40-70 DEG C. The selective additive component comprises a mechanical reinforcing agent and an interface modifier. The preparation method comprises oil phase preparation, water phase preparation, shearing emulsification, ultrasonic refinement, cooling solidification and separation, and washing and drying. The application uses the hydration heat of the magnesium oxide solidification system itself as a trigger signal, ensures that the hydrophobic agent is released only after the main body of the carbonization reaction is basically completed, fundamentally solves the contradiction that the hydrophobic agent hinders the hydration carbonization, and greatly improves the ability of the solidified soil to resist water penetration and acid rain erosion through double protection.

The invention relates to a skin barrier repairing composition and application thereof. The skin barrier repairing composition comprises ceramide NP, vegetable fat, sterol and / or sterol derivatives. The ceramide NP is a mixture of ceramide NP obtained by reaction of behenic acid and phytosphingosine, reaction of myristic acid and phytosphingosine and reaction of oleic acid and phytosphingosine. According to the composition, the vegetable fat, the sterol and / or the sterol derivative and the three specific ceramide NP are creatively combined for use, the combined composition has excellent skin moisturizing and barrier repairing effects, the thickness of an epidermal layer can be increased, and all the components are matched with one another and have a synergistic effect in the aspect of the efficacy. Different from conventional ceramide NP, a ceramide NP compound is adopted, that is, a reaction product of oleic acid and phytosphingosine, a reaction product of behenic acid and phytosphingosine and a reaction product of myristic acid and phytosphingosine are combined for use and are applied to the composition, and compared with other types of ceramide NP, the effect is better.

Mascara compositions with improved aesthetics are provided. Such compositions generally include a plurality of waxes including sunflower seed wax and a plurality of behenates including tribehenin and behenyl behenate. The plurality of waxes may include the sunflower seed wax, the tribehenin, the behenyl behenate, and at least one additional wax. The plurality of waxes may be present in a total amount of about 5% to about 35% by weight of the mascara composition. The combined total amount of sunflower seed wax, tribehenin, and behenyl behenate may be about 5% to about 20% by weight of the composition. The mascara composition may optionally include no more than about 10% water, such as about 2% to about 7%, by weight of the mascara composition.

The present disclosure relates to active molecules and derivatives thereof for use in ovariogenic diseases. In particular, the present disclosure relates to behenic acid or a derivative thereof or a pharmaceutically acceptable salt thereof, a compound of Formula I or a pharmaceutically acceptable salt thereof, or the use of behenic acid or a derivative thereof or a pharmaceutically acceptable salt thereof in combination with a compound of Formula I or a pharmaceutically acceptable salt thereof in the treatment or prevention of ovariogenic diseases.

The invention discloses a phenylbutazone peak shifting sustained release injection. Every 100 g of the phenylbutazone peak shifting sustained release injection is prepared from the following components by weight: 4.0 to 10.0 g of phenylbutazone, 3.0 to 9.0 g of polyethylene glycol 12000, 5.0 to 13.0 g of povidone C15, 8.0 to 18.0 g of ethyl oleate, 4.0 to 8.0 g of span 20, 1.0 to 3.0 g of behenic acid, 0.5 to 2.5 g of propylene glycol alginate, 0.1 to 2.0 g of propyl gallate and the balance of corn oil. The injection contains three kinds of phenylbutazone drug forms, the drug is released in different time periods after intramuscular injection, and the peak value of plasma concentration is staggered, so that the effect of staggered-peak release is realized. According to the technology, on one hand, the highest plasma concentration is reduced, the liver and kidney metabolism burden is remarkably relieved, and the safety is improved, on the other hand, the effective plasma concentration maintaining time is prolonged, the administration frequency is reduced, the stress reaction generated in the animal fixing process is reduced, and time and labor are saved. Meanwhile, the invention further discloses a preparation method, the process is easy to convert, and the application prospect is wide.