Compound essential oil for improving varicosity and preparation method thereof

Abstract

The invention discloses compound essential oil for improving varicosity and a preparation method of the compound essential oil. Comprising the following components: oleic acid, linoleic acid, octanoic acid, decanoic acid, limonene, palmitic acid, alpha-pinene, stearic acid, beta-pinene, gamma-terpinene, 3-cacumen biotae, p-cymene, menthol, menthone, 3-carene, linalool, docosanoic acid, myrcene, sabinene, trans-caryophyllene, isomenthone, citronellol, pulemenone, 4-terpinenol and eudesmol. The compound essential oil disclosed by the invention has excellent effects of improving leg vascular protrusion, obviously improving bluish violet, and relieving soreness and swelling, pain and itching of an affected part.

Description

Technical Field

[0001] The invention belongs to the technical field of medicine, and particularly relates to a compound essential oil for improving varicose veins and a preparation method thereof. Background Art

[0002] Varicose veins are a common vascular disease characterized by venous valve dysfunction, which leads to obstructed blood flow, increased intravenous pressure, and vasodilation and tortuosity. Varicose veins are more common in the lower extremities, and patients often experience symptoms such as heaviness, soreness, pain, and edema. Severe cases can lead to complications such as skin hyperpigmentation, ulcers, and thrombosis, severely impacting patients' quality of life.

[0003] Currently, treatments for varicose veins primarily include surgery and conservative therapies. While surgical treatment is highly effective, it is invasive, expensive, and requires a long recovery period, with a certain risk of recurrence. Conservative treatments primarily include pressure therapy, medications, and lifestyle interventions, with oral and topical medications being the primary treatment options. However, existing medications generally suffer from limited efficacy, significant side effects, and poor patient compliance.

[0004] With the rise of aromatherapy in recent years, essential oils have shown promise in alleviating varicose vein symptoms. Essential oils are volatile aromatic compounds extracted from plants and possess a variety of biological activities, such as anti-inflammatory, antioxidant, and circulation-boosting properties. Some studies have shown that certain essential oils can improve symptoms in patients with varicose veins, but their mechanisms of action remain unclear, and the efficacy of a single essential oil is limited.

[0005] Therefore, developing a safe, effective, easy-to-use compound essential oil that can comprehensively improve the symptoms of varicose veins has important clinical significance and application value. Summary of the Invention

[0006] The present invention aims to provide a compound essential oil for improving varicose veins and a preparation method thereof. The compound essential oil has excellent effects of improving prominent leg blood vessels, obvious bluish purple color, soreness, swelling, pain and itching of the affected area.

[0007] To achieve the above objectives, the technical solutions of the present invention are as follows: A compound essential oil for improving varicose veins, comprising the following components in parts by weight: 20-40 parts of oleic acid, 15-30 parts of linoleic acid, 5-15 parts of caprylic acid, 5-15 parts of capric acid, 1-10 parts of limonene, 1-10 parts of palmitic acid, 1-10 parts of α-pinene, 1-10 parts of stearic acid, 0.5-1.5 parts of β-pinene, 0.5-1.5 parts of γ-terpinene, 0.5-1.5 parts of 3-thujene, 0.1-1 parts of p-cymene, and 0.1-1 parts of menthol. 0.05-0.5 part, 0.1-1 part, menthone, 0.1-1 part, 3-carene, 0.1-1 part, linalool, 0.05-0.5 part, behenic acid, 0.05-0.5 part, myrcene, 0.05-0.5 part, sabinene, 0.05-0.5 part, trans-caryophyllene, 0.05-0.5 part, isomenthone, 0.05-0.5 part, citronellol, 0.05-0.5 part, pulegone, 0.05-0.5 part, 4-terpineol, and 0.05-0.5 part.

[0008] Further, the invention comprises the following components in parts by weight: 25-35 parts of oleic acid, 18-25 parts of linoleic acid, 8-13 parts of caprylic acid, 8-13 parts of capric acid, 5-8 parts of limonene, 5-8 parts of palmitic acid, 3-7 parts of α-pinene, 2-6 parts of stearic acid, 0.8-1.3 parts of β-pinene, 0.5-1.2 parts of γ-terpinene, 0.5-1.2 parts of 3-thujene, 0.2-0.8 parts of p-cymene, 0.2-0.8 parts of menthol, 0.2-0.8 parts of menthone. .3-0.8 parts, 3-carene 0.1-0.5 parts, linalool 0.1-0.5 parts, behenic acid 0.1-0.4 parts, myrcene 0.1-0.4 parts, sabinene 0.1-0.4 parts, trans-caryophyllene 0.1-0.4 parts, isomenthone 0.1-0.4 parts, citronellol 0.1-0.4 parts, pulegone 0.05-0.3 parts, 4-terpineol 0.05-0.3 parts, eucalyptol 0.05-0.3 parts.

[0009] Furthermore, the invention includes the following components in parts by weight: 30 parts of oleic acid, 21 parts of linoleic acid, 12 parts of caprylic acid, 10 parts of capric acid, 6 parts of limonene, 6 parts of palmitic acid, 5 parts of α-pinene, 4 parts of stearic acid, 1 part of β-pinene, 0.7 parts of γ-terpinene, 0.7 parts of 3-thujene, 0.6 parts of p-cymene, 0.6 parts of menthol, 0.5 parts of menthone, 0.3 parts of 3-carene, 0.3 parts of linalool, 0.2 parts of behenic acid, 0.2 parts of myrcene, 0.2 parts of sabinene, 0.2 parts of trans-caryophyllene, 0.2 parts of isomenthone, 0.2 parts of citronellol, 0.1 parts of pulegone, 0.1 parts of 4-terpineol, and 0.1 parts of eucalyptol.

[0010] The method for preparing the compound essential oil for improving varicose veins of the present invention comprises the following steps: a. extracting sweet almonds by a refining method to obtain sweet almond essential oil; b. Using cold pressing method to extract black cumin seeds and tamanu malus to obtain black cumin seed essential oil and tamanu malus essential oil; c. Using cold pressing to extract coconut pulp, and then hydrolyzing it and extracting it by fractionation to obtain coconut essential oil; d. Grind the lemon fruit, extract the essential oil by cold pressing, filter and centrifuge to obtain the volatile oil, and let it stand to obtain lemon essential oil; e. Juniper, cypress, frankincense, helichrysum, peppermint, rose geranium and lavender were crushed to obtain solid plant fragments, which were extracted by steam distillation to obtain juniper essential oil, cypress essential oil, frankincense essential oil, helichrysum essential oil, peppermint essential oil, rose geranium essential oil and lavender essential oil; f. Mix the above components in parts by weight to obtain a compound essential oil.

[0011] Preferably, in step a), the extraction of sweet almonds by a refining method includes the following process: shelling and cleaning the sweet almonds, crushing the sweet almonds into a paste, heating at 60-80°C for extraction to obtain oil, removing the solvent by distillation, and then performing demucining, deacidification and decolorization. Finally, high-temperature vacuum distillation is performed, the extracted product is filtered and the filtrate is collected to obtain oleic acid, linoleic acid, palmitic acid, and stearic acid; the extraction solvent is hexane, and the vacuum distillation temperature is 240-280°C.

[0012] Preferably, in step b), the cold pressing method for extracting black cumin seeds and tamanu malus comprises the following process: physically pressing the black cumin seeds and tamanu malus, separating the oil using a centrifugal separator, filtering the extracted product and collecting the filtrate, wherein the pH value during the extraction process is 6-8 and the temperature is 3-7°C.

[0013] Preferably, in step c), when the extraction is performed by fractionation, the number of fractionation plates is 25 and the reflux index is 2-9.

[0014] Preferably, in step d), the temperature during the cold pressing method for extracting the plant essential oil is controlled at 5-10°C, and the standing temperature is 6°C.

[0015] Preferably, in step e), when the plant essential oil is extracted by steam distillation, the mass ratio of water to plant solid fragments is 4 to 6:1.

[0016] The compound essential oil for improving varicose veins of the present invention Oleic acid can reduce the release of proinflammatory cytokines (such as TNF-α and IL-6) and may alleviate low-grade inflammation associated with chronic venous disease.

[0017] Varicose veins are associated with chronic inflammation and oxidative stress. Caprylic acid can reduce the inflammatory response by inhibiting pro-inflammatory factors (such as NF-κB and IL-6). At the same time, it can be absorbed and converted into ketone bodies, improving energy metabolism and endothelial function, and indirectly supporting vascular health.

[0018] Menthol can relieve the pain and discomfort caused by varicose veins by activating the skin's cold receptors (TRPM8 receptors).

[0019] Cypress essential oil: It has the effect of astringing and strengthening blood vessel walls, which can improve varicose veins, help shrink veins, and relieve pain and swelling.

[0020] Lemon Essential Oil: Helps reduce the appearance and symptoms of varicose veins by promoting blood circulation and providing antioxidant benefits.

[0021] Peppermint essential oil: Improves varicose veins by promoting blood circulation.

[0022] Lavender essential oil: Known for its soothing and circulation-boosting properties, it can help relieve the discomfort associated with varicose veins.

[0023] Compared with the prior art, the present invention has the following beneficial effects: The compound essential oil of the present invention has excellent effects of improving prominent blood vessels in the legs, obvious bluish purple color, soreness, swelling, pain and itching of the affected parts.

[0024] The compound essential oil of the present invention is prepared by compounding a variety of plant extracts and their active ingredients. Among them, juniper extract, cypress extract, etc. are all fat-soluble small molecules, which can easily penetrate the skin barrier and reach the basal layer to exert their effects. They are easier to reach the bottom layer of the skin than general drugs, thereby being absorbed and utilized.

[0025] The compound essential oil obtained by the present invention can be administered in the form of an external preparation, which is convenient and simple to use and highly safe, and can avoid adverse reactions that may be caused by oral medications. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 The figure is a TIC chromatogram of the compound essential oil prepared in Example 1 detected by GC-MS detection method.

[0027] Figure 2 This is a chart showing the improvement in prominent blood vessels in the legs of the subjects using this product.

[0028] Figure 3 This is a chart showing the improvement in leg soreness and pain in the subjects after using this product.

[0029] Figure 4 This is a graph showing the improvement in leg itching in the subjects after using this product.

[0030] Figure 5This is a graph showing the improvement in the purple color of the leg veins in the subjects after using this product.

[0031] Figure 6 This is a graph showing the improvement in leg fatigue in the test subjects after using this product.

[0032] Figures 7-10 These are comparison photos of the subjects before and after using the essential oil of the present invention. DETAILED DESCRIPTION

[0033] The present invention will be further described below in conjunction with the examples and drawings. The following examples are intended only to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods in the following examples where specific conditions are not specified are generally performed under conventional conditions.

[0034] 1. Source of Materials: The sweet almonds, black cumin seeds, tamanu seeds, coconut fruits, juniper, cypress, frankincense, helichrysum, peppermint, rose geranium, lavender, and lemon used in the following examples all comply with the relevant provisions under the Chinese Pharmacopoeia (2015 edition) Volume 1, text, and various medicinal materials. Before feeding, the ingredients were identified as being consistent with their names and meeting quality standards. Extraction was performed using the kernels of sweet almonds, the seeds of tamanu and black cumin, the pulp of coconut, the fruits of juniper, the branches and leaves of cypress, the resin of frankincense, the flowers of lavender and helichrysum, the whole plants of rose geranium and peppermint, and the peel of lemon. 2. Specific embodiments Example 1 A method for preparing a compound essential oil for improving varicose veins comprises the following steps: a. Take 100g of shelled sweet almond kernels, clean the surface, grind the kernels into a paste, heat at 65°C, add hexane to dissolve the oil, obtain the oil, remove part of the solvent by high-temperature distillation at 250°C, and then perform demucining, deacidification and bleaching treatments; b. Take 100 g each of black cumin seeds and tamanu seeds, cleaned and pressed by a machine. The temperature was maintained at 7 ° C during the pressing process, and oxygen and light were isolated. Then, the oil was separated by a centrifuge, the extracted product was filtered, and the second filtrate was collected. c. 100 g of coconut was cleaned, coconut oil was hydrolyzed twice and then washed with water, and then fractionated. The number of distillation plates was 25, the reflux index was controlled at 2 to 9, and then the middle fraction was divided; d. Wash 100 g of lemon peel, place it on a grinding wheel, and rotate it at high speed to pierce the peel, releasing the volatile oil. Simultaneously, water is sprayed to flush the volatile oil down into a receiving tank. The mixture of juice and volatile oil is filtered through a sieve and then centrifuged to separate the volatile oil. The mixture is then placed in a 6°C ice storage for 6 days to allow impurities to settle. The pure volatile oil on the top is then removed using a siphon. e. Wash and crush 100 g each of juniper, cypress, frankincense, helichrysum, peppermint, rose geranium, and lavender powder. Add each to a distillation apparatus with 450 mL of water and steam distill to extract the essential oils at 30°C. After 300 minutes, remove the heat and collect the distillate. f. The above-obtained products were mixed to obtain the compound essential oil of Example 1 and placed in a brown bottle for use.

[0036] The weight parts of the components of the compound essential oil of Example 1 of the present invention are shown in Table 1.

[0037] Example 2 A method for preparing a compound essential oil for improving varicose veins comprises the following steps: a. Take 100g of shelled sweet almond kernels, clean the surface, grind the kernels into a paste, heat at 60°C, add hexane to dissolve the oil, obtain the oil, remove part of the solvent by high-temperature distillation at 240°C, and then perform demucining, deacidification and bleaching treatment; b. Take 100 g each of black cumin seeds and tamanu seeds, cleaned and pressed by a machine. The temperature was maintained at 3 ° C during the pressing process, and oxygen and light were isolated. Then, the oil was separated using a centrifuge, the extracted product was filtered, and the second filtrate was collected. c. 100 g of coconut was cleaned, coconut oil was hydrolyzed twice and then washed with water, and then fractionated. The number of distillation plates was 25, the reflux index was controlled at 2 to 9, and then the middle fraction was divided; d. Wash 100 g of lemon peel, place it on a grinding wheel, and rotate it at high speed to pierce the peel, releasing the volatile oil. Simultaneously, water is sprayed to flush the volatile oil down into a receiving tank. The mixture of juice and volatile oil is filtered through a sieve and then centrifuged to separate the volatile oil. The mixture is then placed in a 6°C ice storage for 6 days to allow impurities to settle. The pure volatile oil on the top is then removed using a siphon. e. Wash and crush 100 g each of juniper, cypress, frankincense, helichrysum, peppermint, rose geranium, and lavender powder. Add each to a distillation apparatus and add 600 mL of water for steam distillation. Extract the plant volatile oils at 30°C. After 300 minutes, remove the heat and collect the distillate. f. The above products were mixed to obtain the compound essential oil of Example 2, and placed in a brown bottle for use.

[0038] The weight parts of the components of the compound essential oil of Example 2 of the present invention are shown in Table 1.

[0039] Example 3 A method for preparing a compound essential oil for improving varicose veins comprises the following steps: a. Take 100g of shelled sweet almond kernels, clean the surface, grind the kernels into a paste, heat at 80°C, add hexane to dissolve the oil, obtain the oil, remove part of the solvent by high-temperature distillation at 280°C, and then perform demucining, deacidification and bleaching treatment; b. Take 100 g each of black cumin seeds and tamanu seeds, cleaned and pressed by a machine. The temperature was maintained at 8 ° C during the pressing process, and oxygen and light were isolated. Then, the oil was separated by a centrifuge, the extracted product was filtered, and the second filtrate was collected. c. 100 g of coconut was cleaned, coconut oil was hydrolyzed twice and then washed with water, and then fractionated. The number of distillation plates was 25, the reflux index was controlled at 2 to 9, and then the middle fraction was divided; d. Wash 100 g of lemon peel, place it on a grinding wheel, and rotate it at high speed to pierce the peel, releasing the volatile oil. Simultaneously, water is sprayed to flush the volatile oil down into a receiving tank. The mixture of juice and volatile oil is filtered through a sieve and then centrifuged to separate the volatile oil. The mixture is then placed in a 6°C ice storage for 6 days to allow impurities to settle. The pure volatile oil on the top is then removed using a siphon. e. Wash and crush 100 g each of juniper, cypress, frankincense, helichrysum, peppermint, rose geranium, and lavender powder. Add each to a distillation apparatus and add 400 mL of water for steam distillation. Extract the essential oils at 30°C. After 250 minutes, remove the heat and collect the distillate. f. The above products were mixed to obtain the compound essential oil of Example 3, which was placed in a brown bottle for use.

[0040] The weight parts of the components of the compound essential oil of Example 3 of the present invention are shown in Table 1.

[0041] Comparative Example 1 a. Take 100 g of cleaned Tamanu seeds and squeeze them physically using a machine. The temperature during squeezing was maintained at 7 ° C. The oil was isolated from oxygen and light. The oil was then separated using a centrifuge. The extracted product was filtered and the second filtrate was collected. b. Wash and crush 100 g each of juniper, cypress, and helichrysum. Add each to a distillation apparatus and add 450 mL of water for steam distillation. Extract the volatile oils at 30°C. After 300 minutes, remove the heat and collect the distillate. c. The products obtained above were mixed to obtain the compound essential oil of Comparative Example 1, which was placed in a brown bottle for use.

[0042] The weight parts of the components of the compound essential oil of Comparative Example 1 are shown in Table 1.

[0043] Comparative Example 2 a. Take 100g of shelled sweet almond kernels, clean the surface, grind the kernels into a paste, heat at 65°C, add hexane to dissolve the oil, obtain the oil, remove part of the solvent by high-temperature distillation at 250°C, and then perform demucining, deacidification and bleaching treatments; b. Take 100 g of lemon peel, wash it, place it on a grinding wheel, and rotate it at high speed so that the thorns of the grinding wheel pierce the peel, causing the volatile oil to flow out. At the same time, water is sprayed to rinse the volatile oil down and flow into a receiving tank. The mixture of juice and volatile oil is filtered through a sieve and sent to a centrifuge to separate the volatile oil. The mixture is placed in an ice storage at 6°C for 6 days to allow impurities to sink, and then the upper layer of pure volatile oil is sucked out with a siphon; c. Wash and crush 100 g each of cypress, rose geranium, and lavender powder. Then, add each to a distillation apparatus with 450 mL of water and steam distill at 30°C to extract the plant's volatile oils. After 300 minutes, remove the heat and collect the distillate. d. The above products were mixed to obtain the compound essential oil of Comparative Example 2, which was placed in a brown bottle for use.

[0044] The weight parts of the components of the compound essential oil of Comparative Example 2 are shown in Table 1.

[0045] Comparative Example 3 a. Take 100g of shelled sweet almond kernels, clean the surface, grind the kernels into a paste, heat at 65°C, add hexane to dissolve the oil, obtain the oil, remove part of the solvent by high-temperature distillation at 250°C, and then perform demucining, deacidification and bleaching treatments; b. Take 100 g of cleaned Tamanu seeds and squeezed them physically. The temperature was maintained at 7 ° C during the squeezing process and the oil was isolated from oxygen and light. The oil was then separated using a centrifuge, and the extracted product was filtered and the second filtrate was collected. c. Wash 100 g of lemon peel, place it on a grinding wheel, and rotate it at high speed to pierce the peel, releasing the volatile oil. Simultaneously, water is sprayed to flush the volatile oil down into a receiving tank. The mixture of juice and volatile oil is filtered through a sieve and then centrifuged to separate the volatile oil. The mixture is then placed in a 6°C ice storage for 6 days to allow impurities to settle. The pure volatile oil on the upper layer is then removed using a siphon. d. Wash and crush 100 g each of juniper, cypress, helichrysum, and rose geranium. Add each to a distillation apparatus and add 450 mL of water for steam distillation. Extract the volatile oils at 30°C. After 300 minutes, remove the heat and collect the distillate. e. The products obtained above were mixed evenly to obtain the compound essential oil of Comparative Example 3, which was placed in a brown bottle for use.

[0046] The weight parts of the components of the compound essential oil of Comparative Example 3 are shown in Table 1.

[0047] Comparative Example 4 a. Take 100g of shelled sweet almond kernels, clean the surface, grind the kernels into a paste, heat at 65°C, add hexane to dissolve the oil, obtain the oil, remove part of the solvent by high-temperature distillation at 250°C, and then perform demucining, deacidification and bleaching treatments; b. Take 100 g of cleaned Tamanu seeds and squeezed them physically. The temperature was maintained at 7 ° C during the squeezing process and the oil was isolated from oxygen and light. The oil was then separated using a centrifuge, and the extracted product was filtered and the second filtrate was collected. c. Wash 100 g of lemon peel, place it on a grinding wheel, and rotate it at high speed to pierce the peel, releasing the volatile oil. Simultaneously, water is sprayed to flush the volatile oil down into a receiving tank. The mixture of juice and volatile oil is filtered through a sieve and then centrifuged to separate the volatile oil. The mixture is then placed in a 6°C ice storage for 6 days to allow impurities to settle. The pure volatile oil on the upper layer is then removed using a siphon. d. Wash and crush 100 g each of juniper, cypress, frankincense, helichrysum, peppermint, rose geranium, and lavender powder. Add each to a distillation apparatus and add 450 mL of water for steam distillation. Extract the plant volatile oils at 30°C. After 300 minutes, remove the heat and collect the distillate. e. The products obtained above were mixed evenly to obtain the compound essential oil of Comparative Example 4, which was placed in a brown bottle for use.

[0048] The weight parts of the components of the compound essential oil of Comparative Example 4 are shown in Table 1.

[0049] Comparative Example 5 a. After washing 100 g of black cumin seeds, the seeds were physically squeezed by a machine. The temperature was maintained at 7 ° C during the squeezing process, and oxygen and light were isolated. Then, the oil was separated using a centrifuge, the extracted product was filtered, and the second filtrate was collected. b 100 g of coconut was cleaned, coconut oil was hydrolyzed twice and then washed with water, and then fractionated, the number of distillation plates was 25, the reflux index was controlled at 2 to 9, and then the middle fraction was divided; c. Wash 100 g of lemon peel, place it on a grinding wheel, and rotate it at high speed to pierce the peel, releasing the volatile oil. Simultaneously, water is sprayed to flush the volatile oil down into a receiving tank. The mixture of juice and volatile oil is filtered through a sieve and then centrifuged to separate the volatile oil. The mixture is then placed in a 6°C ice storage for 6 days to allow impurities to settle. The pure volatile oil on the upper layer is then removed using a siphon. d. Wash and crush 100 g each of juniper, cypress, frankincense, helichrysum, peppermint, rose geranium, and lavender powder. Add each to a distillation apparatus and add 450 mL of water for steam distillation. Extract the plant volatile oils at 30°C. After 300 minutes, remove the heat and collect the distillate. e. The products obtained above were mixed evenly to obtain the compound essential oil of Comparative Example 5, which was placed in a brown bottle for use.

[0050] The weight parts of the components of the compound essential oil of Comparative Example 5 are shown in Table 1.

[0051] Figure 1 The compound essential oil of Example 1 of the present invention was subjected to gas chromatography analysis. The components of the compound essential oil are shown in Table 1.

[0052] 3. Product usage effect: The embodiment with the best overall effect was selected for population testing.

[0053] (1) Product name: Compound essential oil for improving varicose veins prepared by the present invention.

[0054] (2) Product Usage: Apply 0.1g of essential oil to the affected area, spread evenly, gently massage, and wait for the essential oil to be absorbed by itself.

[0055] (3) Frequency of use: Twice a day.

[0056] (4) Testing date: October 2024.

[0057] (5) Use period: 90 days.

[0058] (6) Age range of the subjects: 19-60 years old.

[0059] (7) Subjects: People with varicose veins (protruding blood vessels in the legs, leg soreness, pain, and itching) and other symptoms. Finally, 22 valid reports were obtained.

[0060] The facial skin aging symptoms of the subjects before using essential oils are shown in Table 2. The improvement of skin aging after use is shown in Table 2. Figure 2-Figure 9 shown.

[0061] Figure 2 This is a chart showing the improvement in leg blood vessel protrusion after the subjects used this product. Significant improvement: the improvement rate reached 60% and above; some improvement: the improvement rate reached 20%~60%; no significant change: the improvement rate was less than 20%.

[0062] Figure 3 This is a chart showing the improvement in leg soreness and pain in the test population after using this product. Significant relief: the improvement rate reached 60% and above; some relief: the improvement rate reached 20%~60%; no significant change: the improvement rate was less than 20%.

[0063] Figure 4 This is a chart showing the improvement of leg itching in the subjects after using this product. Significant improvement: the improvement rate reaches 60% and above; some improvement: the improvement rate reaches 20%~60%; no significant change: the improvement rate is less than 20%.

[0064] Figure 5 This is a chart showing the improvement in the cyanosis of the leg veins in the subjects after using this product. Significant improvement: the improvement rate reaches 60% and above; slight improvement: the improvement rate reaches 20%~60%; no improvement: the improvement rate is less than 20%.

[0065] Figure 6 This is a chart showing the improvement in leg fatigue in the test population after using this product. The effect is very good: the improvement rate reaches 60% and above; the effect is average: the improvement rate reaches 20%~60%; and there is almost no effect: the improvement rate is less than 20%.

[0066] Figures 7 to 10 The following is a comparison of facial photos of the test subjects before and after use. It can be seen from the pictures that after using the compound essential oil of the present invention, the symptoms of varicose veins in the legs are effectively improved.

[0067] As can be seen from the above results, a large number of subjects experienced symptoms of prominent leg blood vessels and leg soreness. After using the compound essential oil for improving varicose veins provided by the present invention, these symptoms were effectively improved. At the same time, no significant side effects were observed in the subjects.

[0068] The above description is merely an example of the implementation of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principles of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

[0069] Table 1 Table 2

Claims

1. A compound essential oil for improving varicose veins, characterized in that: The invention comprises the following components in parts by weight: 20-40 parts of oleic acid, 15-30 parts of linoleic acid, 5-15 parts of caprylic acid, 5-15 parts of capric acid, 1-10 parts of limonene, 1-10 parts of palmitic acid, 1-10 parts of α-pinene, 1-10 parts of stearic acid, 0.5-1.5 parts of β-pinene, 0.5-1.5 parts of γ-terpinene, 0.5-1.5 parts of 3-thujene, 0.1-1 parts of p-cymene, 0.1-1 parts of menthol, 0.1-1 parts of menthone. -1 part, 0.1-1 part of 3-carene, 0.1-1 part of linalool, 0.05-0.5 part of behenic acid, 0.05-0.5 part of myrcene, 0.05-0.5 part of sabinene, 0.05-0.5 part of trans-caryophyllene, 0.05-0.5 part of isomenthone, 0.05-0.5 part of citronellol, 0.05-0.5 part of pulegone, 0.05-0.5 part of 4-terpineol, and 0.05-0.5 part of eucalyptol.

2. The compound essential oil for improving varicose veins as claimed in claim 1, wherein The invention comprises the following components in parts by weight: 25-35 parts of oleic acid, 18-25 parts of linoleic acid, 8-13 parts of caprylic acid, 8-13 parts of capric acid, 5-8 parts of limonene, 5-8 parts of palmitic acid, 3-7 parts of α-pinene, 2-6 parts of stearic acid, 0.8-1.3 parts of β-pinene, 0.5-1.2 parts of γ-terpinene, 0.5-1.2 parts of 3-thujene, 0.2-0.8 parts of p-cymene, 0.2-0.8 parts of menthol, 0.3 -0.8 parts, 0.1-0.5 parts of 3-carene, 0.1-0.5 parts of linalool, 0.1-0.4 parts of behenic acid, 0.1-0.4 parts of myrcene, 0.1-0.4 parts of sabinene, 0.1-0.4 parts of trans-caryophyllene, 0.1-0.4 parts of isomenthone, 0.1-0.4 parts of citronellol, 0.05-0.3 parts of pulegone, 0.05-0.3 parts of 4-terpineol, and 0.05-0.3 parts of eucalyptol.

3. The compound essential oil for improving varicose veins as claimed in claim 1, wherein The invention comprises the following components in parts by weight: 30 parts of oleic acid, 21 parts of linoleic acid, 12 parts of caprylic acid, 10 parts of capric acid, 6 parts of limonene, 6 parts of palmitic acid, 5 parts of α-pinene, 4 parts of stearic acid, 1 part of β-pinene, 0.7 part of γ-terpinene, 0.7 part of 3-thujene, 0.6 part of p-cymene, 0.6 part of menthol, 0.5 part of menthone, 0.3 part of 3-carene, 0.3 part of linalool, 0.2 part of behenic acid, 0.2 part of myrcene, 0.2 part of sabinene, 0.2 part of trans-caryophyllene, 0.2 part of isomenthone, 0.2 part of citronellol, 0.1 part of pulegone, 0.1 part of 4-terpineol and 0.1 part of eucalyptol.

4. as claimed in any one of claims 1 to 3, for improving the preparation method of the compound essential oil of varicose veins, it is characterized in that, The steps include: a. extracting sweet almonds by a refining method to obtain sweet almond essential oil; b. Using cold pressing method to extract black cumin seeds and tamanu malus to obtain black cumin seed essential oil and tamanu malus essential oil; c. Using cold pressing to extract coconut pulp, and then hydrolyzing it and extracting it by fractionation to obtain coconut essential oil; d. Grind the lemon fruit, extract the essential oil by cold pressing, filter and centrifuge to obtain the volatile oil, and let it stand to obtain lemon essential oil; e. The juniper, cypress, frankincense, helichrysum, peppermint, rose geranium and lavender were crushed and mixed to obtain solid plant fragments, which were extracted by steam distillation to obtain juniper essential oil, cypress essential oil, frankincense essential oil, helichrysum essential oil, peppermint essential oil, rose geranium essential oil and lavender essential oil; f. Mix the above components in parts by weight to obtain a compound essential oil.

5. The preparation method according to claim 4, wherein: In step a), extracting sweet almonds using a refining method includes the following process: shelling and cleaning the sweet almonds, crushing the sweet almonds into a paste, heating at a temperature of 60-80°C for extraction to obtain oil, removing the solvent by distillation, and then performing demucining, deacidification and decolorization. Finally, high-temperature vacuum distillation is performed, the extracted product is filtered and the filtrate is collected to obtain sweet almond essential oil containing oleic acid, linoleic acid, palmitic acid, and stearic acid; the extraction solvent is hexane, and the vacuum distillation temperature is 240-280°C.

6. The preparation method according to claim 4, wherein: In step b), the cold pressing method for extracting black cumin seeds and tamanu malus includes the following steps: physically pressing the black cumin seeds and tamanu malus respectively, separating the oil using a centrifugal separator, filtering the extracted product and collecting the filtrate, wherein the pH value during the extraction process is 6-8 and the temperature is 3-7°C.

7. The preparation method according to claim 4, characterized in that: In step c), when the extraction is performed by fractional distillation, the number of fractionation plates is 23-27, and the reflux index is 2-9.

8. The preparation method according to claim 4, wherein: In step d), the temperature during the cold pressing method for extracting the plant essential oil is controlled at 5-10°C, and the standing temperature is 6°C.

9. The preparation method according to claim 4, wherein: In step e), when the plant essential oil is extracted by steam distillation, the mass ratio of water to plant solid fragments is 4 to 6:1.

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