The invention belongs to the field of
skin science and formula
engineering, and particularly relates to branched-chain
ceramide with excellent
solubility and a preparation method and application thereof.The branched-chain
ceramide is obtained by docking branched-chain saturated fatty acids such as
isostearic acid, isopalmitic acid and 2-hexyldecanoic acid with
sphingosine bases. Compared with traditional straight-chain
ceramide, the branched-chain ceramide has a lower
melting point, has remarkably higher
solubility in different polar solvents and shows more excellent stability in an
oil phase system, so that high-concentration addition of the branched-chain ceramide in various compound dosage forms such as O / W, W / O,
anhydrous cream, transparent oil gel and a
surfactant system is realized. Meanwhile, the invention provides a green condensation or
enzyme catalysis synthesis
route and
magnification thereof, and provides a representative
structural formula and nuclear magnetic data, and compared with the
solubility and applicability of the traditional straight-chain ceramide, the product provided by the invention is proved to have wide application value in the fields of
skin barrier repair, moisturizing and soothing,
hair care and the like in the future.