Water-based plaster

一种水性贴剂、水性的技术，应用在酸性共聚物粘合剂、粘合剂类型、无机非有效成分等方向，能够解决膏体延展不均匀、延展膏体的时间仅限于短时间、水性粘附基质粘度升高等问题

Active Publication Date: 2014-05-14
TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] In addition, in Patent Document 2, by using an easily soluble aluminum salt as a cross-linking agent, aluminum ions are dissolved immediately after preparation, so the gel strength is high, and gelation proceeds as the extension time becomes longer, and the aqueous adhesion matrix Viscosity increases significantly, so there is a problem that the time to spread the paste on the support is limited to a short time
[0013] Furthermore, regarding the aqueous paste of Patent Document 3, the viscosity of the paste becomes too high in the spreading step, and the spreading of the paste on the support may become uneven.

Method used

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Examples

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preparation example Construction

[0052] The preparation method of the water-soluble patch provided by the present invention is not particularly limited, and it can be prepared according to known preparation methods. For example, a water-based patch can be formed by spreading the adhesive matrix composed of the above-mentioned matrix components on a support, and covering the surface of the water-based matrix with a plastic film.

[0053] As the plastic film covering the substrate on the support body, polyethylene, polypropylene, polyester, and polyvinyl chloride can be used alone or in combination, and silicone treatment, corona discharge, etc. Thin films for processing, embossing, plasma processing, etc.

[0054] Examples of the support include porous bodies such as polyethylene, polypropylene, polyvinyl chloride, polyester, nylon, and polyurethane, foams, woven fabrics, non-woven fabrics, and films or sheets with porous bodies, foams, and woven fabrics. Cloth, laminated products of nonwoven fabrics, etc., p...

Embodiment 1

[0061] Add 2.5 g of purified water to 1.1 g of loxoprofen sodium hydrate, stir and dissolve, as the main drug solution. Next, add 25g 70% D-sorbitol solution, 3g kaolin, 0.5g titanium oxide, 0.5g tartaric acid, 0.06g edetate sodium hydrate, 5.0g 20% ​​polyacrylic acid aqueous solution, 2.5g 33% Polyvinyl alcohol aqueous solution, 1.0 g of methyl acrylate·2-ethylhexyl acrylate copolymer resin emulsion, and the balance (appropriate amount) of purified water were mixed.

[0062] To this solution, a solution obtained by dissolving 0.1 g of methylparaben and 0.05 g of propylparaben in a mixed solvent of 1.0 g of propylene glycol and 0.5 g of peppermint oil was added, and mixed until uniform. Then add the dispersion obtained by dispersing 4.0g sodium carmellose, 5.0g sodium polyacrylate, 0.25g hydroxypropyl cellulose, and 0.09g aluminum dihydroxide glycerin in 20g concentrated glycerin to the solution, evenly mix. Finally, the main drug solution and 3.0 g of isostearic acid were a...

Embodiment 2-7

[0064] According to the mixing formula (unit: weight %) shown in the following Table 1, the water-based patch of each example was prepared in the same manner as in Example 1.

[0065] It should be noted that the formulation of the above-mentioned Example 1 is also described in Table 1.

[0066] [Table 1]

[0067]

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PUM

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Abstract

Provided is a water-based plaster whereby the gel strength of a water-based adhesive base can be retained in an appropriate state during the steps for producing the water-based plaster, in particular a spreading step and conditioning step, and whereby an optimal adhesiveness for adhering to the skin can be exhibited in a final preparation. The present invention is a water-based plaster, characterized in that a water-based adhesive base in which the main ingredient is a water-soluble polymer contains, as a crosslinking modifier, a higher fatty acid which is liquid at room temperature and has a viscosity of 1000 (mPa*s, 20 DEG C) or higher, wherein the higher fatty acid is isostearic acid and the formulated amount thereof is 1-10 wt%.

Description

technical field [0001] The present invention relates to a water-based patch. Specifically, it relates to a water-based adhesive base mainly composed of a water-soluble polymer and a cross-linking agent, which contains a higher fatty acid having a specific viscosity and being liquid at normal temperature as a cross-linking modifier. Water-based patches. Background technique [0002] Water-based patches formed by spreading a water-based adhesive matrix composed of water-soluble polymers, humectants, water, etc. on a support such as non-woven fabrics are marketed as pharmaceutical preparations or coolants for anti-inflammatory, analgesic, etc. widely circulated. [0003] The water-based adhesive matrix is ​​mostly used in the following method: that is, the carboxyl group of polycarboxylic acid and its salt as a water-soluble polymer and the aluminum ion dissolved from the aluminum compound which is one of the matrix components mixed in the water-based adhesive matrix cross-li...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/02A61K47/12A61K47/32A61K47/38
CPCA61K9/7061C09J133/02
Inventor 谷和叶镰仓高志
Owner TEIKOKU SEIYAKU KK TEIKOKU SEIYAKU CO LTD
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