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A nanoemulsion medicine of eugenol and preparation method thereof

A technology of nanoemulsion and eugenol, applied in the directions of drug combination, pharmaceutical formulation, antipyretic, etc., can solve the problems of insoluble eugenol in water, poor stability, etc., and achieve clear and transparent appearance, easy operation and long shelf life. Effect

Inactive Publication Date: 2006-12-13
NORTHWEST A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to aim at above-mentioned defect and deficiency of prior art, provide a kind of eugenol containing nanoemulsion drug that veterinary medicine is clinically used for antibacterial and anti-inflammation, insecticide deworming, antipyretic and analgesic, anti-animal parasite, the present invention generally Making eugenol into nanoemulsion greatly enhances the efficacy of eugenol, and also solves the shortcomings of eugenol that is extremely difficult to dissolve in water and has poor stability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 1) Weigh 0.10g of eugenol, 0.77g of isopropyl myristate, 0.15g of jojoba oil, 0.08g of vitamin E oil, 5.83g of Tween-80, 1.17g of Span-80, deionized 91.90g of water, set aside;

[0054] 2) At room temperature of 25°C, first place the weight of isopropyl myristate, jojoba oil, vitamin E oil, Tween-80 and Span-80 on a constant temperature magnetic stirrer and stir at 300rpm 10min, mix well;

[0055] 3) Slowly add deionized water dropwise to the mixture, and stir while adding dropwise. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal phase or oil-in-water nanoemulsion. Continue to add drops and stir continuously. When the amount of water reaches 24.00g, The system will suddenly become thinner. At this time, the O / W nanoemulsion is produced. Add deionized water to 91.90g to prepare a clear and transparent O / W type nanoemulsion, and finally add the eu...

Embodiment 2

[0057] 1) Weigh 4.62g of isopropyl myristate, 0.92g of jojoba oil, 0.46g of vitamin E oil, 11.67g of Tween-80, 2.33g of Span-80, 85.00g of deionized water, clove Phenol 5.00g, for subsequent use;

[0058] 2) At room temperature of 25°C, first place the weight of isopropyl myristate, jojoba oil, vitamin E oil, Tween-80 and Span-80 on a constant temperature magnetic stirrer and stir at 300rpm 10min, mix well;

[0059] 3) Slowly add deionized water dropwise to the mixture, and stir while adding dropwise. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal phase or oil-in-water nanoemulsion. Continue to add drops and stir continuously. When the amount of water reaches 21.00g, The system will suddenly become thinner. At this time, the O / W nanoemulsion will be produced. Add deionized water to 85.00g to prepare a clear and transparent O / W type nanoemulsion, and f...

Embodiment 3

[0061] 1) Weigh 15.38g of isopropyl myristate, 3.08g of jojoba oil, 1.54g of vitamin E oil, 37.50g of Tween-80, 7.50g of Span-80, 25.00g of ionized water, eugenol 10.00g, spare;

[0062] 2) At room temperature of 25°C, first place the weight of isopropyl myristate, jojoba oil, vitamin E oil, Tween-80 and Span-80 on a constant temperature magnetic stirrer and stir at 300rpm 10min, mix well;

[0063] 3) Slowly add deionized water dropwise to the mixture, and stir while adding dropwise. At the beginning, the viscosity of the system is small. As the amount of water increases, the system will become viscous. At this time, the system may appear liquid crystal phase or oil-in-water nanoemulsion. Continue to add drops and stir continuously. When the amount of water reaches 12.00g, The system will suddenly become thinner. At this time, the O / W nanoemulsion is produced. Add deionized water to 25.00g to prepare a clear and transparent O / W type nanoemulsion, and finally add the eugenol ...

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Abstract

The invention discloses the eugenic nanometer drug, comprising isopropyl microstate, croton oil, vitamin E oil, tuwen-80, spans-80 and eugenic. The drug has the advantages of improving the antibiosis, anti-inflammation, disinfection, analgesic, and ant parasitic. So the drug is green, safe and highly effective ant parasitic agent.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a medicine with antibacterial and anti-inflammatory properties, insecticidal and anthelmintic repellent, antipyretic and analgesic properties, and anti-animal parasite, in particular to a eugenol nanoemulsion medicine and a preparation method thereof. Background technique [0002] Eugenol (Eugenol) is a light yellow or colorless clear oily compound with aroma, and it is a good plant-derived medicine. Eugenol has a wide range of pharmacological effects, mainly antibacterial and anti-inflammatory, anti-corrosion and fresh-keeping, insecticidal and anthelmintic, antipyretic and analgesic, and anti-animal parasites. Because eugenol is a volatile oil, it is extremely difficult to dissolve in water, has poor stability, and is easy to lose during the production and storage of traditional preparations and affect the efficacy of the medicine. It is a technical problem to be solved in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/355A61K31/22A61K31/085A61K47/30A61K9/10A61P31/04A61P33/00A61P29/00
Inventor 欧阳五庆寇贺红
Owner NORTHWEST A & F UNIV
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