Long-acting cefquinome sulfate injection and preparation method thereof

A technology of cefquinoxime sulfate and injection, applied in the field of medicine, can solve problems such as short action time, and achieve the effects of slow release, cost saving, and long-term storage without discoloration

Active Publication Date: 2014-04-30
AMICOGEN CHINA BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing cefquinome sulfate injection has a short action time and needs to be injected once a day for 3-5 consecutive days. It is now developed to reduce the frequency of medication, reduce the stress response of animals, and provide convenience for farmers to meet m

Method used

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  • Long-acting cefquinome sulfate injection and preparation method thereof
  • Long-acting cefquinome sulfate injection and preparation method thereof
  • Long-acting cefquinome sulfate injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example one:

[0030] A long-acting cefquinome sulfate injection, which is composed of the following raw materials:

[0031] Each 100ml injection contains the following components:

[0032]

[0033] The remainder is the solvent for injection

[0034] The suspending agent is hydrogenated castor oil;

[0035] The dispersant is span-60;

[0036] The stabilizer is PG;

[0037] The solvent for injection is ethyl oleate for injection.

[0038] A preparation method of long-acting cefquinome sulfate injection specifically includes the following steps:

[0039] (1) Add 10g of ethyl cellulose and 1g of hydroxypropyl cellulose to 500ml of 70wt% ethanol aqueous solution, and then add 6g of cefquinome sulfate (containing 5g of cefquinome) to the above solution, at room temperature , Stir to dissolve, filter and sterilize through a 0.22μm microporous membrane, and spray-dry to obtain a cefquinome sulfate sustained-release carrier;

[0040] (2) Add 1g hydrogenated castor oil, 0.2g span-60, 0.1g PG ...

Example Embodiment

[0042] Embodiment two:

[0043] A long-acting cefquinome sulfate injection, which is composed of the following raw materials:

[0044] Each 1000ml injection contains the following components:

[0045]

[0046] The remainder is the solvent for injection

[0047] The suspending agent is aluminum stearate;

[0048] The dispersant is span-60;

[0049] The stabilizer is vitamin E;

[0050] The injection vehicle is soybean oil for injection.

[0051] A preparation method of long-acting cefquinome sulfate injection specifically includes the following steps:

[0052] (1) Add 50g of ethyl cellulose and 5g of hydroxypropyl cellulose to 2500ml of 70wt% ethanol aqueous solution, and then add 30g of cefquinoxime sulfate (containing 25g of cefquinoxime) to the above solution, at room temperature , Stir to dissolve, filter and sterilize through a 0.22μm microporous membrane, and spray-dry to obtain a cefquinome sulfate sustained-release carrier;

[0053] (2) Add 5g aluminum stearate, 0.5g span-60, and 1g ...

Example Embodiment

[0055] Embodiment three:

[0056] A long-acting cefquinome sulfate injection, which is composed of the following raw materials:

[0057] Each 10000ml injection contains the following components:

[0058]

[0059] The remainder is the solvent for injection

[0060] The suspending agent is beeswax;

[0061] The dispersant is Tween-80;

[0062] The stabilizers are PG and BHT;

[0063] The injection vehicle is triacetin for injection.

[0064] A preparation method of long-acting cefquinome sulfate injection specifically includes the following steps:

[0065] (1) Add 750g of ethyl cellulose and 100g of hydroxypropyl cellulose to 10000ml of 70wt% ethanol aqueous solution, and then add 120g of cefquinoxime sulfate (containing 100g of cefquinoxime) to the above solution, and at room temperature , Stir to dissolve, filter and sterilize through a 0.22μm microporous membrane, and spray-dry to obtain a cefquinome sulfate sustained-release carrier;

[0066] (2) Add 200g beeswax, 10g tween-80, 1g BHT, 2g...

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PUM

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Abstract

The invention relates to a long-acting cefquinome sulfate injection. The injection is prepared by a method in the following steps: adding cefquinome sulfate into an ethanol solution containing ethyecellulose and hydroxy propyl cellulose; filtering, sterilizing and performing spray-drying to obtain a cefquinome sulfate carrier; adding a suspending agent, a dispersing agent and a stabilizing agent into partial injection solvent, dissolving at 100 DEG C, and adding an injection solvent to the whole amount, and performing dry heat sterilization at 150 DEG C for 1 hour; cooling the dispersion liquid to room temperature, adding the cefquinome sulfate carrier into the dispersion liquid, and uniformly stirring; passing through a high-speed cutting dispersion machine to prepare the long-acting cefquinome sulfate injection. The prepared suspension injection is uniform in granularity, good in fluidity, slow in settlement, good in redispersion property, wall adhesion prevention of liquid medicine, good needle cleaning performance, no discoloration after long-term storage and stable chemical property. After the preparation is injected in a pig in an intramuscular manner, the preparation is slowly released, long in elimination half life and smooth in plasma concentration, can be used for prolonging the effective action duration of the medicine in the body and reducing the number of administration times, and is convenient to use.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of veterinary medicine, in particular to a long-acting cefquinome sulfate injection and a preparation method thereof. Background technique [0002] Cefquinoxime is the fourth-generation cephalosporin antibiotic for animals. It is a broad-spectrum and highly effective cephalosporin antibiotic. Compared with the third-generation cephalosporin, it has a wider antibacterial spectrum and stronger bactericidal effect. Its intrinsic antibacterial activity is stronger than that of the first three generations of cephalosporins. Compared with the first three generations of cephalosporins, the fourth generation of cephalosporins requires less dosage, has strong sensitivity to treating bacteria, has a long plasma half-life, and has no nephrotoxicity. It has a strong killing effect on Staphylococcus aureus, Streptococcus, Pseudomonas aeruginosa, Enterobacteriaceae (Escherichia coli, Sal...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/546A61K47/38A61K47/44A61K47/12A61P31/04
Inventor 胡维智王玲杨春晓金永东宋镇
Owner AMICOGEN CHINA BIOPHARM CO LTD
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