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Huperzine A acupoint sustained-release gel patch for treating senile dementia and preparation method thereof

A slow-release gel patch and huperzine A technology, which is applied in the field of medicine, can solve the problems that patients cannot take medication continuously, and achieve the effects of long drug action time, large drug loading capacity, and high drug transdermal absorption efficiency

Active Publication Date: 2020-09-11
XIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The first object of the present invention is to provide a kind of huperzine A acupoint slow-release gel patch for the treatment of senile dementia, which solves the clinical problems such as nausea, vomiting, abdominal pain, gastrointestinal pain, etc. Disadvantages that some patients cannot continue medication due to adverse reactions such as road discomfort

Method used

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  • Huperzine A acupoint sustained-release gel patch for treating senile dementia and preparation method thereof
  • Huperzine A acupoint sustained-release gel patch for treating senile dementia and preparation method thereof
  • Huperzine A acupoint sustained-release gel patch for treating senile dementia and preparation method thereof

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Experimental program
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Effect test

preparation example Construction

[0047] The above-mentioned preparation method of huperzine A acupoint sustained-release gel patch for treating senile dementia, huperzine A is prepared by fermentation and biosynthesis of the following engineering bacteria, and the engineering bacteria used include: Mucoris racemosa NSH- D strain Mucorracemosus NSH-D (GenBank accession number KX060585.1), Mucor fragilis NSY-1 strain Mucor fragilis NSY-1 (GenBank accession number KX060586.1), Fusarium verticillioides NSH-5 strain Fusarium verticillioides NSH-5 (GenBank accession number KX853851.1), Fusarium oxysporum Fusarium verticillioides NSG-1 (GenBank accession number KX853850.1), Trichoderma harzianum NSW-V strain Trichoderma harzianum NSW-V (GenBank accession number KX034080.1), any of them One or more are refined through the steps of culture and fermentation, ultrasonic crushing of cells, extraction, concentration, purification and drying.

[0048] The key points of the present invention are described below from the pri...

Embodiment 1

[0053] Step 1: According to the requirements of the preparation, according to the mass percentage, weigh 0.0083% huperzine A, 2.7546% borneol, 0.6121% sodium polyacrylate NP-800, 1.3517% sodium polyacrylate NP-700, 2.4485% Titanium dioxide, 0.1530% aluminum glyoxate, 0.0918% EDTA-2Na, 35.1404% glycerin, 3.6728% PVP-K120, 0.1530% tartaric acid, 47.3089% purified water, 0.1836% preservatives (ethylparaben and Butylparaben 4:1), 6.1213% of 95% ethanol, the sum of the mass percentages of each component is 100%;

[0054] Step 2: Shake and mix the sodium polyacrylate NP-800, sodium polyacrylate NP-700, titanium dioxide, aluminum glycolate and EDTA-2Na weighed in step 1 in a sealed, clean and dry plastic bag to obtain a solid phase for later use;

[0055] Step 3: Add the glycerin weighed in step 1 into a vacuum mixer, then add the solid phase obtained in step 2, and then stir for 10 minutes under the condition that the vacuum degree is not lower than -0.05MPa to obtain the glycerin p...

Embodiment 2

[0061] Step 1: According to the requirements of the preparation, according to the mass percentage, weigh 0.0091% huperzine A, 4.3929% borneol, 1.0138% sodium polyacrylate NP-800, 0.9182% sodium polyacrylate NP-700, 3.3792% Titanium dioxide, 0.2365% aluminum glycylate, 0.1690% EDTA-2Na, 38.0966% glycerin, 4.7309% PVP-K90, 0.2365% tartaric acid, 39.7886% purified water, 0.2703% preservatives (ethylparaben and Butylparaben 4:1), 6.7584% of 95% ethanol, the sum of the mass percentages of each component is 100%;

[0062] Step 2: Shake and mix the sodium polyacrylate NP-800, sodium polyacrylate NP-700, titanium dioxide, aluminum glycolate and EDTA-2Na weighed in step 1 in a sealed, clean and dry plastic bag to obtain a solid phase for later use;

[0063] Step 3: Add the glycerin weighed in step 1 into a vacuum mixer, then add the solid phase obtained in step 2, and then stir for 10 minutes under the condition that the vacuum degree is not lower than -0.05MPa to obtain the glycerin p...

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Abstract

The invention discloses a huperzine A acupoint sustained-release gel patch for treating senile dementia and a preparation method thereof. When in use, the sustained-release gel patch is applied to theDazhui acupoint of the governor meridian of a patient, huperzine A is absorbed by the skin of the Dazhui acupoint and distributively enters the brain tissues to play a role in brain-targeted treatment, and entry of drugs into the blood circulation system is reduced, so that adverse reactions are avoided; and meanwhile, the patch belongs to a novel hydrogel drug delivery system, a preparation matrix is soft, comfortable and high in skin affinity, the patch is safe, non-irritating and non-allergic to the skin, and the drug action time is long, so that the drug delivery frequency is reduced. Therefore, the patch solves the problem of poor curative effect or adverse reactions caused by the fact that AD patients often forget to take medicines or take excessive medicines or take wrong medicinesdue to weakened memory and reduced intelligence, provides a novel medicinal preparation which is reliable in curative effect, convenient to use, safe and non-toxic for the treatment of the AD patients, and has important clinical values and wide market prospects.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a huperzine A acupoint sustained-release gel patch for treating senile dementia, and also relates to a preparation method of the huperzine A acupoint sustained-release gel patch. Background technique [0002] Alzheimer's disease, also known as senile dementia (Alzheimer's disease, AD), is a neurodegenerative disease characterized by progressive dementia such as memory, cognitive ability and self-care ability. After 7 to 10 years of death. According to the latest statistics from the World Health Organization (WHO), there were approximately 47 million dementia patients worldwide in 2017, with 9.9 million new cases each year. "World Alzheimer's Disease Report 2018" reported that China's elderly population exceeded 212 million in 2014. With the intensification of population aging, AD patients are expected to reach 152 million by 2050; Countries with the most patients. In 2015, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/4748A61K47/10A61K47/32A61P25/28
CPCA61K9/7023A61K31/4748A61K47/10A61K47/32A61P25/28Y02A50/30
Inventor 韩文霞李伟泽
Owner XIAN MEDICAL UNIV
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