8 results about "Allergy medications" patented technology

The invention relates to the technical field of electronic prescriptions, in particular to a dynamic electronic prescription generation method and system based on artificial intelligence. The method comprises the following steps: collecting the latest physiological state parameter flow of a patient, carrying out real-time health state evaluation, and generating a personalized patient state map; historical medical records of a patient are extracted, time sequence pathological evolution tracking is carried out, and a pathological evolution trajectory is generated; performing multi-parameter time sequence difference comparison calculation and drug curative effect quantitative evaluation based on the personalized patient state map and the pathological evolution trajectory to obtain a curative effect evaluation report; performing allergic drug identification on the patient based on the historical medical record of the patient, and performing secondary drug screening to obtain a drug candidate set; and performing intelligent matching calculation on the drug candidate set according to the curative effect evaluation report, and performing combinatorial optimization analysis to generate a final effective electronic prescription. The electronic prescription is automatically updated and adjusted based on the state change of the patient, the risk of allergic prescriptions is reduced, and the safety of the prescriptions is improved.

The present application relates to the application of an acidic goat milk oligosaccharide composition in the preparation of an anti-allergy drug or food, the composition comprising 24 acidic sugar chains 24SMAOs, among which, according to the classification of sialic acid structure, 12 Neu5Ac modified sialylation sugar chains, 10 Neu5Gc modified sialylation sugar chains and 2 sialylation sugar chains modified by both Neu5Ac and Neu5Gc, according to the classification of sialic acid connection mode, 11 alpha2,3 connected sialic acid sugar chains, 10 alpha2,6 connected sialic acid sugar chains and 3 sialic acid sugar chains connected by both alpha2,3 and alpha2,6. The composition belongs to a natural anti-allergy substance, has safety and effectiveness, and realizes excellent anti-allergy performance.

The utility model discloses a medicine allergy prompting disc, which relates to the technical field of medical instruments and comprises a shell, a display disc is arranged in the shell, an observation port is arranged on the shell, a limiting ring is arranged in the shell, the limiting ring is rotatably connected with a rotating shaft, and the rotating shaft is fixedly connected with the central position of the display disc. Through the arrangement of the display panel and the observation opening, eight groups of allergic drug areas are arranged on the display panel in an array mode, different types of allergic drugs are recorded in each group of areas, and when a treatment post nurse is reminded of allergic conditions of a patient and the allergic drugs are prompted through the drug allergy prompting panel, the rotating shaft rotates in the limiting ring, so that the allergic drugs are prompted to the patient through the drug allergy prompting panel; after an area for recording allergic drugs of a patient is rotated to an observation opening, a treatment post nurse can be reminded of the drug allergy type of the patient, medical negligence caused by wrong use of drugs is avoided, safety is improved, and practicability of the drug allergy prompting disc is improved.

The invention provides application of FTY720 in preparation of a medicine for preventing and / or treating food allergy, and belongs to the technical field of medicine. The invention provides application of FTY720 in preparation of a medicine for preventing and / or treating food allergy. Animal experiments prove that the FTY720 can relieve the decrease of the body temperature of a mouse with food allergy; weight loss of mice with food allergy is relieved; the diarrhea occurrence rate of food-allergic mice can be reduced, and the possibility of diarrhea occurrence is reduced; the serum OVA specific IgE antibody level of a food allergy mouse can be reduced; the serum OVA specific IgG1 antibody level of the food allergy mouse is reduced; the jejunum tissue damage of a mouse with food allergy is relieved or relieved; the jejunum inflammatory factor level of food-allergic mice is reduced; the intestinal flora and the like of a mouse with food allergy are improved. The FTY720 provided by the invention can be used for preparing medicines for preventing and / or treating food allergy.

The invention belongs to the technical field of biological medicines, and particularly relates to application of a compound in preparation of an anti-allergic medicine. The degranulation inhibition effect is verified through a mast cell in-vitro culture model, the overall anti-allergic activity is verified by combining an animal allergy model, and a series of experiments prove that the compound A33 can inhibit I-type anaphylaxis (such as ear and subcutaneous anaphylaxis) mediated by an IgE antibody. Different from a traditional anti-allergic drug (such as an antihistamine drug), the compound A33 is used for preventing release of media such as TNF-alpha and IL-6 from the source in an anaphylactic reaction starting link that the compound A33 directly inhibits mast cell degranulation in allusion to downstream blocking of an allergic medium, so that the compound A33 is introduced into the field of anti-allergic product research; a new candidate strategy with a clear targeting mechanism and an experimental basis is provided for prevention and / or treatment of allergic diseases, and the application value in anti-allergic drugs, cosmetics or daily chemical products is wide.

The application discloses application of a Corydalis yanhusuo extract in preparation of an anti-allergic drug and belongs to the technical field of anti-allergic drug preparation. The treatment effect of the drug on allergic diseases is evaluated by comparing P815 cell degranulation and inflammatory factor release, the inflammatory infiltration degree of a local skin allergic reaction of a mouse, and the allergic symptoms of a mouse as a whole, so that it is determined that the Corydalis yanhusuo extract can be used for preparation of an anti-allergic drug. The Corydalis yanhusuo extract can effectively alleviate the local and systemic allergic reaction symptoms of a mouse, and reduce mast cell degranulation, and has a significant improvement effect on symptoms caused by allergic reactions.

This invention discloses a fusion peptide with synergistic anti-allergic effects, an anti-LTB4 monoclonal antibody, and an anti-allergic drug composition thereof. The fusion peptide is composed of peptide A, which inhibits histamine release, and peptide B, which blocks mast cell activation signals, covalently linked by a linker peptide, which can synergistically inhibit mast cell activation. The anti-LTB4 monoclonal antibody can specifically bind to LTB4, blocking its mediated inflammatory response. Combining the fusion peptide, the anti-LTB4 monoclonal antibody, and myricetin, which has antioxidant activity, forms a multi-target drug composition that can synergistically inhibit allergic reactions from multiple aspects, such as inhibiting mast cell degranulation, blocking the action of inflammatory mediators, and clearing oxidative stress products. In vitro cell experiments and OVA-induced allergic asthma mouse models have demonstrated that the anti-allergic effect of this composition is significantly better than that of a single component, and it has no obvious toxicity, providing a new candidate drug for the efficient treatment of allergic diseases.

The invention discloses a mast cell targeted hydrogen sulfide controlled release nano stabilizer as well as a preparation method and application thereof, and belongs to the technical field of nano biological materials and drug delivery. The nano stabilizer (SMSNs (at) SC (at) HA) takes tetrasulfide bond bridged mesoporous organosilicon nanoparticles as a skeleton, an anti-allergic drug sodium cromoglycate (SC) is loaded in mesoporous channels of the mesoporous organosilicon nanoparticles, and hyaluronic acid (HA) is modified on the surfaces of the nanoparticles through covalent bonds. Wherein the tetrasulfide bond can be broken in a reducing environment in cells, so that not only can the controllable and continuous release of hydrogen sulfide gas be realized, but also the degradation of the skeleton structure of the nano stabilizer can be induced, and the release behavior of the loaded drug SC can be cooperatively regulated and controlled; hA realizes targeted recognition of mast cells in a receptor mediation mode, and non-specific leakage of the medicine in a body fluid environment is effectively reduced. The preparation method of the nano stabilizer provided by the invention is mild in process condition, good in repeatability and convenient for industrial amplification. In addition, the nano stabilizer is further applied to a passive skin anaphylaxis model, and a new strategy is provided for preparing the long-term and safe nano stabilizer with a targeting function.