32 results about "Allergy medications" patented technology

The invention discloses Graphostroma sp. 3A00421 and applications of fermentation compounds of the Graphostroma sp. 3A00421, wherein the Graphostroma sp. 3A00421 is preserved in China Center for TypeCulture Collection on October 30, 2017, and has the preservation number of CCTCC NO: M 2017637, and the preservation address is Wuhan University in Wuhan city in China. According to the present invention, the fermentation compounds of the Graphostroma sp. 3A00421 have anti-allergic activity and anti-inflammatory activity, and can be used for preparing anti-allergic or anti-inflammatory drugs; andthe new compound source is provided for the research and development of anti-allergic and anti-inflammatory drugs, the important significance is provided for the development of marine drugs in China,the effective applications of deep-sea microbial resources can be promoted, and good application prospect is provided.

The invention discloses an antibacterial and hypoallergenic adult paper diaper and a preparation method thereof. The diapers are sequentially superimposed with a skin-friendly layer, a liquid instant absorption layer and a leak-proof water-proof layer, which are prepared by hot pressing; the skin-friendly layer is made of natural antibacterial materials chitosan and antibacterial drugs combined with inorganic materials, and adopts electrospinning technology The preparation of non-woven fabrics has a high specific surface area and good absorption. The release of antibacterial drugs loaded in inorganic materials can effectively inhibit bacteria and reduce bacterial growth; the absorbent fiber non-woven fabric is used in the liquid instant absorption layer, and at the same time Adding water-absorbing polymers and nano-activated carbon particles to form multiple barriers, not only has the function of air permeability and high water absorption, but also has the characteristics of natural antibacterial and deodorizing. When the ambient temperature is high, moisture and heat are easy to pass through. It is not easy to produce heat and diaper rash; at the same time, the addition of antibacterial and anti-allergic drugs can reduce the growth of bacteria, do not irritate the user's skin, and improve comfort and safety.

The invention discloses Penicillium commune T3-1 (Penicillium commune T3-1) and its fermentation compound, extraction and purification method and application in anti-allergy. The Penicillium commune T3-1 (Penicillium commune T3-1) of the present invention is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 2017123, the preservation address is China. Wuhan. Wuhan University, and the preservation date is March 2017 15th of May. The structural formula of the compound obtained by the fermentation and extraction of Penicillium commune T3-1 of the present invention is shown in formula (I) and formula (II): it is found through experiments that it has strong anti-allergic activity and can be used for preparing and development of anti-allergic drugs. The invention provides a new compound source for the research and development of anti-allergic drugs, is of great significance to the development of marine drugs in my country, can also promote the effective application of deep-sea biological resources, and has good application prospects.

The invention discloses a transdermal therapeutic system of huperzine A and derivatives thereof. A patch disclosed by the invention is safe, non-irritating and non-allergic to skin, and long in drug action time, so that the administration frequency is reduced. The medicine can be continuously released for a long time, the peak valley phenomenon of blood concentration caused by oral administration is avoided, the first-pass effect of the liver and degradation of the medicine in the gastrointestinal tract are avoided, the transdermal therapeutic system is suitable for patients who fall asleep, do not react or cannot swallow the oral medicine (the compliance of the patients is improved), and administration can be interrupted at any time when side effects are found.

The invention discloses the application of coyne in the preparation of anti-allergic drugs, by comparing the degranulation of KU812 cells, the degree of swelling of the toes, the degree of Evans blue exudation of the toes, HE staining of foot skin tissue sections, and the release of serum histamine To evaluate the drug group to be tested, the normal saline control group and the normal control group, to evaluate the therapeutic effect of the drug on allergic diseases, and to determine that coyne can be used in the preparation of anti-allergic drugs. Coin can effectively alleviate the symptoms of local and systemic allergic reactions in mice; reduce mast cell degranulation and significantly improve the symptoms caused by allergic reactions.

The invention discloses the application of vitamin K3 in the preparation of anti-allergic drugs. Vitamin K3 has a clear therapeutic effect on improving anaphylactoid symptoms. By comparing the degranulation of KU812 cells, the degree of swelling of the toe, and the degree of Evans blue exudation of the toe , Serum histamine release evaluation test drug group, normal saline control group and normal control group, to evaluate the therapeutic effect of drugs on allergic diseases, to determine that vitamin K3 can be used in the preparation of anti-allergic drugs. Vitamin K3 can effectively alleviate the symptoms of local and systemic anaphylaxis in mice; reduce mast cell degranulation and significantly improve the symptoms caused by anaphylaxis.

The invention discloses application of Licochalcone A in preparation of an antiallergic drug. A to-be-detected drug group, a normal saline control group and a normal control group are evaluated by comparing a mastocyte degranulation degree, a mouse toe swelling degree, a toe Evans blue exudation degree and a body temperature lowering degree, so that the treatment effect of the drug for allergic diseases is evaluated; a result determines that the Licochalcone A can be used for preparing the antiallergic drug. The Licochalcone A can effectively relieve local and systemic anaphylactic reaction symptoms of mice. Mastocyte degranulation is reduced, and symptoms caused by allergy are remarkably eliminated.

The invention relates to an anti-allergic sulfated polysaccharide and its preparation method and application. The anti-allergic sulfated polysaccharide uses sulfated polysaccharide as a raw material to remove divalent metal ions, and has the characteristics of low molecular weight and high sulfuric acid group content The molecular weight of the anti-allergic sulfated polysaccharide is 600Da-1000Da, and the retention of sulfate groups relative to the raw material sulfated polysaccharide is ≥95% by mass. The antiallergic sulfated polysaccharide prepared by the invention has simple production process and high production efficiency, and the obtained sulfated polysaccharide has strong antiallergic activity, and is very suitable for developing antiallergic drugs or functional foods.

The invention discloses a class of andrastone compounds derived from deep-sea fungi, a preparation method thereof and an application in the preparation of antiallergic drugs. The structures of the andrastone compounds 1-14 derived from deep-sea fungi are shown in formulas I-XIV respectively, and can be used for preparing antiallergic drugs.

The invention provides a quinazolinone-containing diaryl urea compound and a preparation method and application thereof. The quinazolinone-containing diaryl urea compound can obviously inhibit LAD2 cells from releasing beta-hexosaminidase, shows obvious dosage association, can be used for preparing an antiallergic medicament, and particularly can be used for preparing a medicament for antagonizingLAD2 cells from releasing beta-hexosaminidase so as to reduce pain and a load of a patient. The preparation method provided by the invention is easy in obtaining of raw material sources, mild in reaction condition, simple in operation in the reaction process and cheap in used reagent.

The invention discloses the application of the deep-sea fungus Graphstroma sp. 3A00421 and its fermentation compound. The deep-sea fungus Graphstroma sp.3A00421 of the present invention is preserved in the China Center for Type Culture Collection, the preservation number is CCTCC NO: M 2017637, the preservation address is Wuhan University, China, and the preservation date is October 30, 2017. The fermented compound of the deep-sea fungus Graphstroma sp.3A00421 of the invention has anti-allergic and anti-inflammatory activities, and can be used to prepare anti-allergic drugs or anti-inflammatory drugs. The invention not only provides a new compound source for the research and development of anti-allergic and anti-inflammatory drugs, is of great significance to the development of marine drugs in my country, but also promotes the effective application of deep-sea microbial resources and has a good application prospect.

The invention discloses antiallergic drug coating composition. The antiallergic drug coating composition is characterized by comprising antiallergic drug particles and polymer A particles, wherein the polymer A is selected from sodium alginate or chitosan, and the antiallergic drug particles account for 15%-20% of the total mass. The drug composition is applied to the inside of the paranasal sinus (by spraying or brushing) to form a drug coating, drug ingredients in the coating are released slowly, and long-term fixed-point and quantitative administration to the part of lesion can be realized. The invention further provides a preparation method and an application of the composition.

The invention discloses the application of the fermented compound of Aspergillus terreus H768 in the preparation of antiallergic medicine. Aspergillus terreus fermentation compound of the present invention is obtained by fermentation and extraction of Aspergillus terreus H768, and its structural formula is as shown in formula (I): Aspergillus terreus H768 (Aspergillus terreus H768), preserved in China Type Culture Collection Center, preservation number It is CCTCC NO: M 2017121, and the deposit address is China. Wuhan. Wuhan University, and the deposit date is March 15, 2017; the invention finds that the Aspergillus fermented compound has strong anti-allergic activity and can be used to prepare anti-allergic drugs. The invention provides a new source of compounds for the research and development of anti-allergic drugs, which is of great significance to the development of marine drugs in my country, and can also promote the effective application of deep-sea biological resources, and has a good application prospect.

A red algae oligosaccharide and its preparation method and application relate to red algae polysaccharide. Red algae oligosaccharides are red algae polysaccharides with a molecular weight of 2-150kDa and are in powder form. The red algae polysaccharide is prepared into a polysaccharide solution, cooled after reaction, and then added with vitamin C for reaction, after removing the residual vitamin C, then added with absolute ethanol for precipitation and dried to obtain the red algae oligosaccharide. The red algal oligosaccharides can be used in the preparation of antiallergic drugs. According to production needs, it is established to use pressure and vitamin C to degrade red algae polysaccharides to obtain powdered red algae oligosaccharides with a molecular weight of 2-150kDa. The red algae oligosaccharide obtained by degradation through the method has low viscosity, good solubility and strong antiallergic effect. The invention has the characteristics of simple equipment and process, low cost and easy production and application.

The invention discloses a pharmaceutical composition and an application thereof in treating rhinitis, and relates to the technical field of rhinitis treatment. Through combined administration of vitamin C and antiallergic medicines, immunity of a human body and strain capacity to abnormal changes are improved, so that symptoms of rhinitis and allergic recurrence become more and more slight, and the effect of treating rhinitis is gradually achieved.

The invention discloses the application of a compound in the preparation of antiallergic medicine, characterized in that the molecular formula of the compound is C 29 H 27 NO 8 , its chemical structural formula is: the present invention finds that the compound T-5224 can significantly inhibit the release of β-aminoglycosidase in mast cells, has the effect of significantly inhibiting the degranulation of mast cells, and can significantly inhibit allergy in mice reaction. This fully shows that the T-5224 compound can be used to prepare antiallergic drugs and has broad application prospects.

The invention discloses an anthraquinone compound from fungi in deep sea and application of the anthraquinone compound in preparation of antiallergic drugs. The structure of the anthraquinone compoundfrom fungi in deep sea is shown in formula (I), and the anthraquinone compound can be used for preparing the antiallergic drugs.