Microneedle capable of controllably releasing medicine and preparation method of microneedle

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a microneedle capable of controllably releasing medicines and a preparation method of the microneedle. The microneedle comprises needle bodies and a substrate, wherein the needle bodies are distributed on the substrate in an array; the needle body comprises a shaping material, a solvent A and a medicine, and the weight ratio of the shaping material to the solvent A is (5-30): (70-95); the substrate is a soluble substrate or an insoluble substrate; the insoluble substrate is composed of a non-woven fabric, a spunlace fabric or a medical adhesive tape; the soluble substrate comprises a base material and a solvent B, and the weight ratio of the base material to the solvent B is (0.5-20): (80-99.5). The preparation method comprises the following steps: preparing the needle body fluid, preparing the substrate and preparing the microneedle. According to the microneedle capable of controllably releasing the medicine, due to the fact that the dissolution rates of the needle body shaping material in tissue fluid are different, the release rates of the medicine in the microneedle are different, and the purpose of controllable medicine release is achieved; and the shaping material is a biocompatible material and has the advantages of safety, no toxicity and no residue.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a microneedle for controlled and sustained release of medicines and a preparation method thereof. Background technique [0002] According to different administration methods, drugs are divided into dosage forms such as oral preparations, injections, ointments, and patches, and dosage forms are selected according to the stability and site of action of raw materials. Oral preparations, injections and other dosage forms will inevitably cause damage to the liver, gastrointestinal tract, etc. during use, and the release and stability of the drug may be affected when the oral preparation passes through the stomach. Therefore, in recent years, transdermal drug delivery There is a growing body of research on drug use patterns. [0003] Microneedle is a form of transdermal drug delivery. When in use, the microneedle body penetrates the stratum corneum of the skin and enters the epiderm...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that the existing microneedles are easy to release and remain, the present invention provides a microneedle with controlled release of drugs and a preparation method thereof. The microneedle includes a needle body and a base, the needle body is located on the base, and the needle body contains There are drugs, because the dissolution rate of the needle excipient material in the interstitial fluid is different, the release rate of the drug in the microneedle is different, and the purpose of drug release can be controlled; the excipient material is a biocompatible material, which is safe, non-toxic, The advantage of no residue; the preparation method of the microneedle is simple and easy to control, suitable for a wide range of applications

Images