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Medicinal composition for treating allergic rhinitis and preparation method and application thereof

A technology of allergic rhinitis and composition, which is applied in the direction of drug combination, pharmaceutical formula, drug delivery, etc., which can solve the problems of rare reports of topical nasal drug use, and achieve the effects of prolonging the drug action time, reducing aggregation, and alleviating allergic reactions

Active Publication Date: 2010-12-08
FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, traditional Chinese medicines are mostly oral preparations in the treatment of AR, and reports on topical nasal administration are relatively rare.

Method used

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  • Medicinal composition for treating allergic rhinitis and preparation method and application thereof
  • Medicinal composition for treating allergic rhinitis and preparation method and application thereof
  • Medicinal composition for treating allergic rhinitis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] The preparation of embodiment 1 pharmaceutical gel drops of the present invention

[0038] a. Take the following raw materials by weight:

[0039] Xu Changqing 20g, cicada slough 4.5g, natural borneol 0.03g, artificial bezoar 0.3g

[0040] b. Take Xu Changqing, add 20 times the amount of water based on the weight of the crude drug, soak for 30 minutes, use steam distillation, extract for 3 hours, collect the distillate, add sodium chloride to refrigerate and crystallize, the volume of the distillate is the same as that of sodium chloride The mass ratio is 100:5, filter, and vacuum dry to obtain paeonol crystals; take paeonol crystals, add appropriate amount of ethanol to dissolve them, and then slowly add them to saturated aqueous solution of β-cyclodextrin, paeonol crystals and β -The mass ratio of cyclodextrin is 1:8, at 45°C, 800r / min stirring inclusion compound for 1 hour, refrigerated for 24 hours, filtered, vacuum-dried to obtain paeonol-cyclodextrin inclusion co...

Embodiment 2

[0046] The preparation of embodiment 2 pharmaceutical gel drops of the present invention

[0047] 1. Extraction process of paeonol in Xu Changqing

[0048] Add 20 times the prescription amount of Xu Changqing and cicada slough with water, soak for 0.5 hours, decoct for 3 hours, collect the distillate, add 5% (g / ml) sodium chloride, refrigerate for 24 hours, filter, wash the crystals with distilled water several times, Vacuum dry at room temperature.

[0049] 2. Paeonol inclusion process

[0050] Take 2g of paeonol and dissolve it in 12ml of ethanol, slowly drop it into 400ml of β-cyclodextrin saturated aqueous solution at a temperature of 45°C, stir for 1h (800r / min), refrigerate for 24h, and filter. A small amount of ethyl acetate was washed 3 times and dried. Vacuum dry at room temperature.

[0051] 3. Borneol inclusion process

[0052] Dissolve 1g of borneol in 10ml, slowly drop into 280ml of β-cyclodextrin saturated aqueous solution, water temperature 30°C, stirring t...

Embodiment 3

[0056] Embodiment 3 Preparation of medicament spray of the present invention

[0057] Get Xu Changqing 14g, cicada slough 5.85g, borneol 0.039g, bezoar 0.39g, extract medicinal materials according to the method described in Example 1, add conventional auxiliary materials to the concentrated solution, put into a spray bottle, and prepare a spray.

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Abstract

The invention provides a medicinal composition for treating allergic rhinitis, which is a medicament prepared from the following traditional Chinese medicines in part by weight: 14 to 26 parts of paniculate swallowwort root, 3.15 to 5.85 parts of cicada slough, 0.021 to 0.039 part of borneol and 0.21 to 0.39 part of bezoar. The invention also provides a preparation method and application of the medicinal composition. The medicinal composition has the effects of expelling wind, reducing heat, and causing resuscitation and refreshing nose and has an obvious clinical treatment effect. Efficacy trials show that drops of the medicinal composition relieves allergic reaction of nasal meatus by reducing AR guinea pig blood LTE4, IgE concentration, inhibiting the release of inflammatory mediator and reducing the aggregation of inflammatory cells on mucous membrane of nose.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating allergic rhinitis. Belongs to the field of medicine. Background technique [0002] Allergic rhinitis (AR), also known as allergic rhinitis, is a type I allergic reaction of nasal mucosa induced by the release of histamine, kinins and leukotrienes mediated by immunoglobulin E (IgE). The main symptoms are nasal itching, sneezing, runny nose, and nasal congestion. In recent years, 10% to 25% of the world's people suffer from allergic rhinitis, and the incidence rate has been increasing year by year. Although AR is not a serious disease, it can affect patients' daily life such as sleep, study, and work, and can induce bronchial asthma, sinusitis, nasal polyps, otitis media, and allergic conjunctivitis. Therefore, seeking effective treatment methods and drugs is a topic of global concern. [0003] Currently, Western medicines for AR mainly include antihistamines, glucocorticoids, deconge...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61K9/00A61K9/12A61K9/06A61P11/02A61P37/08A61K31/045A61K35/413A61K35/64
Inventor 郑健褚克丹徐伟林雄艾斯李煌严国鸿潘旭东
Owner FUJIAN UNIV OF TRADITIONAL CHINESE MEDICINE
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