124 results about "Mucous membrane of nose" patented technology

The present invention includes benzodiazepine compositions formulated for intranasal administration, comprising a binary solvent system comprising a first solvent in which the benzodiazepine is soluble, the first solvent capable of penetrating nasal mucosal tissue, and a second solvent in which the benzodiazepine in less soluble. The compositions of the present invention may be used to treat a variety of disorders including, but not limited to, panic attacks, muscle spasms, anxiety, and seizures. In one aspect, the present invention relates to a fast-acting, clonazepam composition for transnasal administration that can be used for the treatment of seizure clusters.

The invention provides a pharmaceutical formulation comprising:

(1) THAM, which is tris(hydroxymethyl)aminomethane, as a selective absorbefacient to enhance through the nasal mucosa-lined epithelium the absorption of substances of peptide nature; and

(2) a therapeutically effective amount of active nasal peptide, its pharmaceutically acceptable salt or its peptidic fragment; in a pharmaceutically acceptable, aqueous liquid diluent or carrier, said formulation being in a form suitable for nasal administration.

This invention belongs to chemistry pharmaceutical field and relates to a medication transfer system, especially relates to an agglutinin masked medication-load transfer mechanism transferring from nose to brain. This invention comprises medication carrier nanograin, vesicle or lipid body surface finish agglutinin. By using the transfer system, resort time of medication-load system on nasal mucosa can be prolonged, dielectric mucosa absorb the medication-load system and selectively deliver small molecular chemistry medication, diagnosis medication, polypeptide proteins and gene medication into brain. This invention can deliver more medication into brain and relatively decrease medication in outer tissue, so it can depress toxic action at every pore while toning up prevention, cure and diagnosis effect of backbone diseases.

The invention belongs to the technical field of medicines, and relates to an antigen covalently bound chitosan nanoparticle-based nasal immune carrier and a preparation method thereof. The carrier is composed of a nanoparticle and an antigen, the antigen is covalently bound to the surface of the nanoparticle, and the nanoparticle is prepared by adopting a raw material chitosan and its derivatives; and the antigen is selected from from infectious diseases or tumors related proteins or polypeptides. The carrier can significantly improve the neck lymph node targeting of people nasally dosed with the antigen proteins or polypeptides, enhances the mucosal and systemic immune response, has the advantages of simple preparation, stable process, high antigen utilization rate, difficult antigen shedding, benefiting of the improvement of the cervical lymph node transportation of the antigens, good nasal immune effect and no nasal mucosa toxicity, and is suitable for preventing respiratory infectious diseases.

The invention discloses a culture medium and culture method of a nasal mucosa tissue. According to the culture medium and culture method of the nasal mucosa tissue, epithelial-mesenchymal/matrix components are integrated in an organoid culture system based on a gas-liquid interface method for the first time, and by inducing proliferation and differentiation of adult stem cells in a fresh nasal mucosa epithelial tissue, an organoid which is composed of multiple kinds of cells, including ciliated cells, goblet cells, club cells and basal cells, and is close to an internal mucosa in structure andfunction can be obtained, and becomes an in-vitro nasal mucosa model with proliferation and multi-lineage differentiation capability.

The invention discloses a nasal cavity channel diameter detection tube and relates to the field of medical consumables. The detection tube is provided with a detection tube body, wherein the front end of the detection tube body is provided with a guide part which is small in front and big in back, and the outer side of the detection tube body is provided with a length mark; the upper portion and the lower portion of the tube wall of the guide part are provided with through holes, a measuring air bag is arranged outside the portion, behind the guide part, of the detection tube body and connected with an inflator through an inflatable pipe via a one-way valve, and the inflator is provided with a scale which corresponds to the diameter of the measuring air bag and reflects the air injection amount; the detection tube body is connected with a breathing machine or an aspirator through an inlet and can provide an oxygen supply channel or suck secreta in the nasal cavity. The detection tube can achieve measurement of the passing diameter of the nasal cavity channel to provide a basis for choosing a proper cannula or catheter for a nasal trachea cannula and avoid aspiration by mistake caused by nasal mucosa damage and bleeding when an improper cannula or catheter is adopted.

The invention discloses nasal cavity washing liquid for treating rhinitis. The nasal cavity washing liquid comprises the following components in parts by mass: 50-100 parts of a traditional Chinese medicine extraction solution, 0.1-0.2 part of medium-molecular sodium hyaluronate, 0.1-0.2 part of micromolecular sodium hyaluronate, 8.5-9.5 parts of sodium chloride and 850-900 parts of distilled water, wherein the traditional Chinese medicine extraction solution is prepared from a traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components: 100-150 parts of boat-fruited scaphium seeds, 150-220 parts of flos chrysanthemi, 20-60 parts of herba houttuyniae, 40-80 parts of radix bupleuri and 40-100 parts of herba menthae. The washing liquid is capable of cleaning the nasal cavity and is also capable of accelerating recovery of damaged nasal mucosa and rapidly curing rhinitis fundamentally.

The invention relates to black cumin seed oil nose drop and a preparation method thereof. The black cumin seed oil nose drop is prepared from black cumin seed oil or from black cumin seed oil, scabrous mosla herb, herba ephedra, radix angelicae, violet magnolia, centipeda minima, schizonepeta and radices sileris in a compounding manner. The black cumin seed oil nose drop disclosed by the invention is used for directly acting on the mucosa of the nasal cavity, becomes effective rapidly, and can relieve inflammatory cell infiltration of the nasal mucosa caused by rhinitis and nasosinusitis and inhibit hyperplasia of connective tissues below the mucosa so as to improve nasal obstruction caused by swelling of the nasal mucosa, so the black cumin seed oil nose drop is suitable for treating various rhinitis and has a better effect than clinical commonly-used biyanling pills, centipeda minima nasal drops and the like.

The invention discloses a traditional Chinese medicine liquid preparation for treating rhinitis and a preparation method thereof. The liquid preparation comprises 500 to 800 parts of main liquid preparation, and several parts of auxiliary components and rice vinegar; wherein the main liquid preparation is prepared by decocting main medicinal raw materials such as radix bupleuri, balloonflower root, herba schizonepetae, coptidis rhizoma, and centipede with water, and the auxiliary components comprise a scallion liquid, a garlic liquid, borneol, and ethanol. The liquid preparation is mainly used to treat rhinitis, nasosinusitis, and nasal polyp, and has the advantages of little using amount, user-friendliness, direct act on nasal mucosa, improvement on the blood circulation of nasal mucosa, rapid absorption, prominent curative effect, no side effect, and no drug resistance. The clinical observation results have shown that the cure rate of 2900 clinical treatments on rhinitis, nasosinusitis, and nasal polyp can reach 84% to 85%.

The invention discloses a rhinitis therapeutic instrument. The instrument comprises a shell covering a nose, wherein a first belt is connected between the two side edges of the shell, a second belt isconnected between the upper edge of the shell and the middle of the first belt, extending rods extending into a nasal cavity is installed on the lower edge of the rear face of the shell, far infraredlamp beads are installed at the other ends of the extending rods, and massage structures are installed on the rear side face of the shell and located at the Yingxiang acupoint, the Bitong acupoint and nose wings. The instrument has the advantages that the Yingxiang acupoint, the Bitong acupoint and the nose wings are massaged through a massage magnet to stimulate the acupoints to promote blood circulation around the nose, infrared light irradiation is conducted on the interior of the nasal cavity through the far infrared lamp beads, subcutaneous tissue is permeated to expand nasal mucosa capillaries, blood circulation and cell tissue metabolism are promoted, the damaged nasal mucosa is repaired, a damaged nasal mucosa is repaired, nasal cavity inflammation is relieved, so that rhinitis, allergic rhinitis and the like are relieved and treated.

The invention relates to a parathyroid hormone 1-34 pharmaceutical composition and a preparation method thereof. Specifically, the invention relates to a parathyroid hormone 1-34 pharmaceutical composition, which contains parathyroid hormone 1-34 as an active ingredient and a pharmaceutically acceptable carrier, and the carrier at least comprises a buffer solution, a penetration enhancer, a stabilizer and a preservative. The parathyroid hormone 1-34 pharmaceutical composition is a parathyroid hormone 1-34 nasal spray or a nasal spray combination. The parathyroid hormone 1-34 nasal spray or thenasal spray combination prepared by the method has the advantages that the first-pass effect is avoided, and the bioavailability is high; the effect taking is fast; the administration is convenient,the patient compliance is strong, the nasal spray is subjected to nasal mucosa absorption in the use process, and can be used for favorably reducing the pain of injection administration of polypeptidedrugs and the like.

The invention relates to a medicine and a preparation for treating allergic rhinitis and a preparation method of same. The medicine includes Western medicines and traditional Chinese medicines, wherein the Western medicines include, by weight, 38-42 parts of clindamycin and 27-33 parts of lidocaine, and the traditional Chinese medicines include, by weight, 50-100 parts of storax, 15-30 parts of borneol, 10-30 parts of artificial musk, and 50-80 parts of centipeda minima. Through combination of the Western medicines and traditional Chinese medicines, damaged nasal mucosa can be rapidly repairedand allergy symptoms are eliminated. The medicine is convenient to use, has reliable and significant curative effects, is good in safety, and is suitable for adults and childrens.

The invention relates to a disposable nasal mucosa dosing device. The device comprises a nasal cavity plug body, a cover body, a rod body, a push rod and an injector, wherein a rear end of the nasal cavity plug body is coupled with a front end of the cover body, the rear end of the cover body is coupled with the front end of the rod body, the rear end of the rod body is coupled with the front endof the injector, and the push rod is slidably and hermetically mounted in the injector; a fluid discharge outlet is connected with an inner cavity of the nasal cavity plug body; the inner cavity of the nasal cavity plug body, the inner cavity of the cover body and the inner cavity of the rod body are connected with the injector; and the push rod includes a push rod far section and a push rod nearsection, the push rod far section is connected with the push rod near section through an easily-broken structure, a push rod front end boss is arranged at the front end of the push rod far section, and the push rod front end boss is selectively connected with a rod body radial boss in a one-way clamping mode. In the invention, a possibility of repeated use is prevented, use is more sanitary and safer, and the device has advantages of a simple structure, convenience in production and assembly and the like.

The invention provides a double-channel negative pressure drainage nasal irrigator. The double-channel negative pressure drainage nasal irrigator comprises a water inlet cover, a clear water tank, a waste water tank, a cavity, a nasal plug bracket, a water inlet valve, a vacuum pump, a double-gear pressing type switch and a conveying pipeline. By means of the structure, the nasal cavity cleaning process is mild and efficient in the mode that the vacuum pump is arranged for vacuumizing to drive the cleaning water, meanwhile, nasal mucosa cannot be damaged, waste water after cleaning does not flow out by arranging the waste water tank, therefore the use convenience of a user is greatly improved, and meanwhile the use experience of the user is improved while refreshing breathing is achieved.

The invention belongs to the technical field of medical instruments, and particularly relates to a hypertonic seawater nasal cavity sprayer. The hypertonic seawater nasal cavity sprayer is composed of a spraying tank, a nozzle and a nozzle cover, the spraying tank is filled with spraying liquid, and the spraying liquid is prepared from, by mass, 0.8%-1.6% of sodium bicarbonate, 2%-2.5% of sea salt, 0.5%-1% of glycerinum, 0.5%-1.5% of a protective agent, 0.3%-0.6% of an adhesive, 0.003%-0.005% of essence and 92.795%-95.897% of purified water. The spray liquid in the hypertonic seawater nasal cavity sprayer has no stimulation effect on nasal mucosa after being sprayed out, has no cilia toxicity, can effectively avoid damage to the nasal mucosa due to long-term use, and greatly improves the use safety of the product.

The invention belongs to the technical field of medicine and relates to temperature-sensitive in situ gel for nasal administration. The temperature-sensitive in situ gel is prepared by dissolving a reverse temperature-sensitive material, namely 'methyl cellulose-polyethylene glycol-sodium citrate' three-component system, as a gel substrate in water. The gel preparation is characterized in that byadjusting the gelling temperature and selecting a proper surfactant, the medicine solubility is increased; and after the preparation is in contact with the surface of the nasal mucosa, the preparationis changed to semi-solid gel with proper strength at nose temperature, so that the semi-solid gel can stay on the surface of the nasal mucosa for a relatively long time. The temperature-sensitive insitu gel for nasal administration, provided by the invention, can prolong the retention time of the medicine in the nasal cavity, thereby increasing the local absorption of the medicine and prolongingthe medicinal effect.