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The present application relates to a kind of micro CO efficient removal adsorbent and its preparation and application, the preparation method includes the following steps: (1) active carbon powder, active component A, inorganic clay and dispersing agent are placed in ball mill and are uniformly ground, and mixture material is obtained;(2) active component B and the water solution of reducing agent are atomized and sprayed into the mixture material, then glue is added, and wet material is obtained;(3) wet material is extruded into shape by template, after heat reduction, after drying, calcination, CO removal adsorbent is obtained, i.e. target product;Active component A is monovalent copper salt, and active component B is the mixture of lanthanum chloride and at least one of cerium chloride or yttrium chloride.The strength and adsorption capacity of the CO removal adsorbent of the present application are increased by more than 30% and 25% respectively, the strength is ≥40N / cm, the wear is ≤1.5wt%, the CO adsorption capacity is ≥35ml / g (40℃), the removal precision can reach below 0.01ppm, suitable for the efficient purification of trace CO in hydrogen, nitrogen and other raw gas.

The invention discloses a photochemical synthesis method of a vonoprazan intermediate, and belongs to the technical field of drug intermediate synthesis, the synthesis method comprises the following steps: (1) 2-bromo-1-(2-fluorophenyl) ethyl-1-ketone and acetaldehyde are subjected to a white light irradiation reaction under the action of a photosensitizer and alkali to obtain 4-(2-fluorophenyl)-4-oxobutyraldehyde; (2) carrying out a Paal-Knorr condensation reaction on the 4-(2-fluorophenyl)-4-oxobutyraldehyde and ammonium acetate under the action of an acid catalyst and a dehydrating agent, so as to obtain 2-(2-fluorophenyl)-1H-pyrrole; (3) carrying out formylation reaction on the 2-(2-fluorophenyl)-1H-pyrrole and 1, 1-dichloromethoxymethane under the action of a Lewis acid catalyst, so as to obtain a vonoprazan intermediate; the method has the advantages of cheap and easily available raw materials, high product yield, safe and simple process, mild reaction conditions and low cost, and is suitable for industrial production.