A cover (20) for a computer mouse (1) having a first section (24A) for covering a first mouse button (12A), a second section (24B) for covering a second mouse button (12B), and a third section (23) for covering the main body (11). The cover may be made from natural or synthetic fabric or material, animal skins, furs or hides, may be woven or non-woven, may be smooth, furry, rough, textured, stippled, may be made in any desired color, colors, pattern or patterns, pictures, photographs, and logos. An adhesive (31) secures the cover to the mouse and the cover may be treated with an antibacterial or other agent to retard the growth of undesired organisms.