83 results about "Gastric lumen" patented technology

An intragastric device generally comprises a strip digestive-resistant mesh material that is operable between a first configuration and a second configuration. The first configuration is sufficiently small to permit introduction of the digestive-resistant mesh material into a gastric lumen of the mammal. The second configuration is sufficiently large to prevent the digestive-resistant mesh material from passing through the mammals pylorus, thereby permitting the mesh member to act as an artificial bezoar. Methods and devices for delivering the mesh member are also provided, including a pusher that is operable to engage and disengage the mesh member for delivery through the gastric lumen via a delivery sheath.

Devices and methods for tissue acquisition and fixation, or gastroplasty, are described. Generally, the devices of the system may be advanced in a minimally invasive manner within a patient's body, e.g., transorally, endoscopically, percutaneously, etc., to create one or several divisions or plications within the hollow body organ. Such divisions or plications can form restrictive barriers within a organ, or can be placed to form a pouch, or gastric lumen, smaller than the remaining stomach volume to essentially act as the active stomach such as the pouch resulting from a surgical Roux-En-Y gastric bypass procedure. Moreover, the system is configured such that once acquisition of the tissue by the gastroplasty device is accomplished, any manipulation of the acquired tissue is unnecessary as the device is able to automatically configure the acquired tissue into a desired configuration.

Devices and methods for tissue acquisition and fixation, or gastroplasty, are described. Generally, the devices of the system may be advanced in a minimally invasive manner within a patient's body, e.g., transorally, endoscopically, percutaneously, etc., to create one or several divisions or plications within the hollow body organ. Such divisions or plications can form restrictive barriers within a organ, or can be placed to form a pouch, or gastric lumen, smaller than the remaining stomach volume to essentially act as the active stomach such as the pouch resulting from a surgical Roux-En-Y gastric bypass procedure. Moreover, the system is configured such that once acquisition of the tissue by the gastroplasty device is accomplished, any manipulation of the acquired tissue is unnecessary as the device is able to automatically configure the acquired tissue into a desired configuration.

Devices and methods for tissue acquisition and fixation, or gastroplasty, are described. Generally, the devices of the system may be advanced in a minimally invasive manner within a patient's body, e.g., transorally, endoscopically, percutaneously, etc., to create one or several divisions or plications within the hollow body organ. Such divisions or plications can form restrictive barriers within a organ, or can be placed to form a pouch, or gastric lumen, smaller than the remaining stomach volume to essentially act as the active stomach such as the pouch resulting from a surgical Roux-En-Y gastric bypass procedure. Moreover, the system is configured such that once acquisition of the tissue by the gastroplasty device is accomplished, any manipulation of the acquired tissue is unnecessary as the device is able to automatically configure the acquired tissue into a desired configuration.

An apparatus and method comprising at least one intragastric member or artificial bezoar made of a digestive-resistant or substantially indigestible material that is introduced into a gastric lumen of a mammal for the treatment of obesity. The intragastric member or artificial bezoar is typically at inserted into the gastric lumen in a partially compacted configuration, whereby it is then manipulated into, or allowed to assume, a second expanded configuration sufficiently large to remain within the reservoir of the stomach during normal activities and not be passed through the pylorus into the intestines. In animals, the present invention has been found to be effective in achieving weight loss over a several month period, while being easy to place and retrieve.

An apparatus and method comprising at least one intragastric member comprising a curvilinear axis which extends about and along a central axis of an intragastric device or artificial bezoar made of a digestive-resistant or substantially indigestible material that is introduced into the gastric lumen of a mammal for the treatment of obesity. One or more intragastric members are loaded onto an outer delivery tube in a partially compacted first configuration and delivered to an overtube. The overtube includes a proximal end, a distal end and a main lumen configured to receive the intragastric member in the first configuration for delivery to the gastric lumen wherein the intragastric member is expanded to a second configuration.

A gastric balloon apparatus. An apparatus is disclosed that is insertable into a patent's stomach for treatment of overweight. The balloon occupies a volume of the gastric lumen to provide a sensation of fullness after the consumption of only modest amounts of food. The balloon apparatus has a basic toroidal shape to prevent blockage of the entrance or exit lumens of the stomach and promote proper passage of food through the stomach, while protecting the stomach lining from ulceration and irritation. A series of toroidal balloons of graduated diameter may be joined by inner and outer sleeves to define a funnel-shaped apparatus which expands when food is ingested, thus satiating the patient with substantially reduced quantity of food. A balloon storage and insertion apparatus also is disclosed, whereby a gastric balloon according to the disclosure may be pre-inflated and stored ion a tube for later use, whereupon the pre-inflated balloon is deployed into the stomach. Various mechanisms are disclosed for providing a pre-determined deflation of an inserted balloon, permitting the deflated balloon to be excreted from the body.

An intragastric catheter provides a method of inducing satiety due to its presence in the stomach cavity. Efficacy is improved by the tactile sensation provided by a plurality of fingers that extend from the device. Normal peristaltic action upon the device moves the fingers relative to the stomach. The structure of the intragastric catheter reduces the level of precision required in placement of the device, and blockage of conduits to and from the stomach by the device is unlikely.

The invention comprises a gastric device having a pouch formed from a degradable film. Preferably, the pouch contains a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

An apparatus for accessing the gastric lumen, allowing elaborate intragastric surgeries to be carried on. The apparatus consists of two parts; an external part and a transgastric part. The named external part is a cylinder ending in a larger part of different shapes, the external part will be equipped with a mechanism to allow instruments to get inside the stomach while preventing gas from escaping out. It will also contain a gas delivery port to allow insufflation of the stomach through the cannula. The named transgastric part consists of a cylinder of variable lengths ending in an internal gastric bolster that will be either solid-type or balloon-type. This part is attached to a tapering introduction system ending in a wire loop to be used for introduction of this part. The apparatus also includes an extraction catheter to be used during removal of transgastric part with solid-type gastric bolster.

Devices and methods for tissue acquisition and fixation, or gastroplasty, are described. Generally, the devices of the system may be advanced in a minimally invasive manner within a patient's body, e.g., transorally, endoscopically, percutaneously, etc., to create one or several divisions or plications within the hollow body organ. Such divisions or plications can form restrictive barriers within a organ, or can be placed to form a pouch, or gastric lumen, smaller than the remaining stomach volume to essentially act as the active stomach such as the pouch resulting from a surgical Roux-En-Y gastric bypass procedure. Moreover, the system is configured such that once acquisition of the tissue by the gastroplasty device is accomplished, any manipulation of the acquired tissue is unnecessary as the device is able to automatically configure the acquired tissue into a desired configuration.

A device for creating a channel between the stomach lumen and the abdominal surface of a patient. The device includes a tube and a first bolster. The tube has a proximal end, a distal end, and a wall, the wall having an inner surface and an outer surface, and each end having an opening therein. The first bolster is attached to the distal end of the tube and the tube is adapted to slidably receive a feeding device having a shaft, wherein at least a portion of the outer diameter of the shaft of the feeding device is substantially the same size as that of the inner wall of the tube. The first bolster is adapted to sealingly engage with the patient so as to minimize or avoid fluid leakage about the tube. The present invention is also directed to a method of using an artificial stoma.

An apparatus and method comprising one or more intragastric balloons comprising a foam material disposed within the gastric lumen of a mammal. When the foam material is disposed within the one or more balloons, the one or more intragastric balloons are configured to prevent the intragastric device from passing through the mammal's pylorus. The one or more intragastric balloons are loaded onto a delivery tube in a partially compacted first configuration and delivered through an overtube. The overtube includes a proximal end, a distal end and a lumen configured to receive the one or more intragastric balloons in the first configuration for delivery into the gastric lumen wherein the one or more intragastric balloons are expanded to a second configuration upon delivery of the foam material. The foam material is delivered through an inflation tube attached to an opening of the one or more intragastric balloons.

The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

An apparatus and method comprising at least one intragastric member or artificial bezoar made of a digestive-resistant or substantially indigestible material that is introduced into a gastric lumen of a mammal for the treatment of obesity. The intragastric member or artificial bezoar is typically at inserted into the gastric lumen in a partially compacted configuration, whereby it is then manipulated into, or allowed to assume, a second expanded configuration sufficiently large to remain within the reservoir of the stomach during normal activities and not be passed through the pylorus into the intestines. In animals, the present invention has been found to be effective in achieving weight loss over a several month period, while being easy to place and retrieve.

An apparatus and method comprising at least one intragastric member made of a digestive-resistant or substantially indigestible material that is introduced into a bag located in the gastric lumen of a mammal for the treatment of obesity. One or more intragastric members are loaded into a delivery tube in a partially compacted first configuration and delivered to an overtube. The overtube includes a proximal end, a distal end and a lumen configured to receive the intragastric members in the first configuration for delivery to the bag located in the gastric lumen wherein the intragastric member is expanded to a second configuration. The apparatus further comprises a constraining element engaged with the bag to secure the intragastric member upon delivery into the gastric lumen.

An esophageal balloon catheter capable of quickly and safely providing esophageal gauging and stenting as well as gastric aspiration during esophageal surgery. The esophageal balloon catheter includes (i) a shaft which defines a gastric lumen and an inflation lumen, (ii) a single inflatable balloon sealingly attached to the shaft at a fixed longitudinal position proximate the distal end of the shaft in fluid communication with the inflation lumen, and (iii) an aspiration port through the shaft between the balloon and the distal end of the shaft in fluid communication with the gastric lumen. The gastric lumen is not in fluid communication with the inflation lumen or the balloon so as to allow aspiration of the stomach without causing inflation or deflation of the balloon.

An intragastric device and method of use thereof are provided. The device is actuated to change its volume based on one or parameters detected in the gastric lumen. The device comprises an expandable reservoir that is adapted to distend one or more walls of the gastric lumen for a predetermined time. The device may also be actuated based on a pressure control system in which the reservoir maintains a constant pressure against the walls of the gastric lumen.

An apparatus comprising an intragastric member re-configurable from a first configuration to a second configuration, the first configuration being sufficiently small to permit introduction of said intragastric member into a gastric lumen of a mammal, the second configuration being sufficiently large to prevent said intragastric device from passing through the mammal's pylorus, wherein said intragastric member comprises a plurality of spaced apart openings. The intragastric member comprises an elongate member having a proximal end and a distal end, wherein the elongate member is threaded through the openings of the intragastric member, and the intragastric member is disposed between the proximal end and the distal end of the elongate member. The apparatus also comprises a proximal stopper engaged to the distal end of the elongate member and a proximal stopper engaged to the proximal end of the elongate member for securing the intragastric member upon delivery into the gastric lumen of the patient. The elongate member can also comprise a cinching member to facilitate delivery of the intragastric member into the gastric lumen of the patient.

Methods and apparatus for quantifying the amount or rate of magnetically susceptible fluid within a gastric lumen are described. In one aspect, a magnetic sensor located external to the patient is configured to detect a quantity of fluid disposed within the gastric lumen. The quantity of fluid may include fluid that is contained upstream with respect to a restriction formed in the gastric lumen (e.g., by a gastric restriction device). The quantity of fluid disposed within the gastric lumen is determined by the magnetic sensor. This quantity may be evaluated over time to then calculate a real time flow rate which can then be displayed to the physician. The methods and devices allow a physician or other trained person to dynamically view real time development of fluid flow within a restricted gastric lumen and may be used in conjunction with adjustments to the gastric restriction device to achieve target or desired flow rates.

The invention describes a percutaneous gastrointestinal anchoring kit having an anchor, an introducer, a guide, an inflator, and a retainer. The anchor contains a ballooned region and a shaft portion. The retainer secures the anchor within the stomach when the ballooned region is inflated by seating against an exterior surface of the patient body and placing a tractive force on the ballooned region so as to pull the gastric lumen to an interior abdominal wall of the patient body. The introducer is used to insert the anchor initially within the stomach. The guide positions the ballooned region of the anchor within the stomach by enabling manipulation from an exterior surface of the patient body. The inflator is used to selectively inflate or deflate the ballooned region as needed.

A tracheo-oesophageal fistula catheter (1) comprises an elongate conduit (2) having a proximal and a distal end, the conduit (2) comprising a plurality of lumens commencing adjacent to the proximal end; means (8, 9) for substantially sealing a tracheo-oesophageal fistula, the means being attached to the conduit (2) adjacent to the proximal end and comprising two elements (8, 9) to be placed on either side of the fistula; and at least one expandable balloon (7) attached to the conduit (2) adjacent to the distal end, and in fluid connection with at least one of said lumens; wherein at least one lumen is a gastric lumen, the gastric lumen extending along the full length of the conduit and having an outlet (6) at the distal end of the conduit (2), and wherein at least one element of the means for sealing the fistula comprises an expandable balloon in fluid connection with at least one of said lumens.

The present invention is related to oral compositions comprising an irreversible gastric H+ / K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor and succinc acid as a parietal cell activator in the gastric lumen. The compositions of the present invention are capable of enhancing the anti-acid activity of PPI in the stomach. The present invention further relates to a method of using such compositions to reduce gastric acid secretion in a mammal.

A method of reducing the cross-sectional area of a gastrointestinal lumen is provided wherein a delivery catheter having a needle, one or more anchors disposed within the needle and a suture coupled to each anchor is advanced into the gastrointestinal lumen, the needle extended through the tissue wall, and an anchor ejected from a distal tip of the needle through the tissue wall. The needle is then repositioned against an opposing tissue wall, another anchor deployed from the needle through the opposing tissue wall, and the tissue walls approximated by applying tension to the sutures.

An enteral feeding catheter (5) that provides access to both the stomach and the jejunum for feeding, aspiration and decompression. The catheter includes a dual lumen “D” tube (30) that joins to an external “Y” connector (25) at the proximal end of the tube. The connector serves both lumens as a source for fluid or aspiration. The gastric lumen (37) and the jejunal lumen (38) of the “D” tube both connect to a transitional connector bolus in the stomach. The gastric lumen of the “D” tube joins with a lumen in the transitional bolus that communicates with a gastric port (27). The gastric port is recessed to the level of its full internal lumen, thereby providing maximum protection against occlusion and maximum area for outflow. The “D” jejunal lumen connects in the bolus with a lumen that transitions from a “D” shape to a full circle shape. The latter provides for the attachment of a smaller, round, single lumen tube that extends into the jejunum. At the distal end of the jejunal tube is a bolus (11) containing an improved port that is also recessed to the level of the floor of the internal tube lumen to provide maximum protection against occlusion and maximum area for outflow. Both the gastric port in the transitional bolus and the jejunal port in the tip bolus may include a structural arch protruding radially outwardly therefrom. An arch is effective to prevent the body segment of either bolus from bending and restricting the ports. The invention also provides for the insertion of the tube over a guidewire (21) rather than with an internal stylet, as is normally the case with nasally inserted tubes.

An intragastric member and method of delivery thereof are described. Delivery of the intragastric member is enabled by partitioning the intragastric member into discrete bundles with retaining members that are circumferentially disposed along the longitudinal length of the intragastric member. Formation of the intragastric member into bundles facilitates controlled delivery into the gastric lumen. The use of suture ties enables deployment of the intragastric member into the gastric lumen. The distal ends of the suture ties are affixed to the bundles. Pulling on the proximal free end of each of the suture ties enables the corresponding bundles to be advanced distally along a delivery tube. The suture ties are pulled until each of the bundles slide off from the delivery tube and enter into the gastric lumen

A delivery system and method of use thereof for introducing a bundled intragastric bag into a gastric lumen are described. The delivery system includes a pushing mechanism movable between an unexpanded and expanded configuration. The pushing mechanism in its expanded configuration pushes each of the bundles of the bag into the gastric lumen. A suture strand is periodically pulled during the procedure to help create doughnut-shaped bundles. Another suture strand extends between a proximal button and distal button of the deployed assembly to maintain the doughnut-shaped bundle structure.

The present invention is related to novel oral compositions comprising an irreversible gastric H+ / K+-ATPase proton pump inhibitor (PPI) as a gastric acid secretion inhibitor, pentagastrin (PG) or a PG analogue as an activator of parietal cells in the gastric lumen. In a preferred embodiment, the composition further comprises at least one agent that preserves the availability of PG in the gastric fluids, thus enabling PG to act locally in the stomach. Unexpectedly, the compositions of the present invention exhibit anti-acid activity locally in the stomach that is meal-independent, exhibit fast onset and prolonged inhibition of acid secretion.

The invention comprises a gastric device having an outer region and a gas producing material. The gastric device hydrates within a patient's stomach and the gas producing material expands the device to a greater volume. Accordingly, the volume of the hydrated, expanded gastric devices occupy space in the stomach cavity and reduce the amount of food the patient will ingest before reaching the feeling of fullness. Preferably, the gastric device is made from food grade materials. The gastric device is configured to expand to a desired volume and then degrade after a residence time, allowing the device to be passed by the patient's normal digestive process.

An intragastric member and method of delivery thereof are described. Delivery of the intragastric member is enabled by partitioning the intragastric member into discrete bundles with retaining members that are circumferentially disposed along the longitudinal length of the intragastric member. Formation of the intragastric member into bundles facilitates controlled delivery into the gastric lumen. The use of suture ties enables deployment of the intragastric member into the gastric lumen. The distal ends of the suture ties are affixed to the bundles. Pulling on the proximal free end of each of the suture ties enables the corresponding bundles to be advanced distally along a delivery tube. The suture ties are pulled until each of the bundles slide off from the delivery tube and enter into the gastric lumen.