Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Nasal spray of seaweed extract and preparation method of nasal spray

A technology of seaweed extract and nasal spray, which is applied in the directions of medical preparations, antiviral agents, and pharmaceutical formulations containing active ingredients, and achieves the effects of convenient use, simple operation and obvious effect.

Inactive Publication Date: 2013-09-18
LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH +1
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] There have been many studies and reports on the antiviral activity and effect of seaweed polysaccharides in the above patents before the application of the above patents, and in the examples of the above patents, there is no preparation process of nasal spray or other dosage forms, only the description of the virus test

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Nasal spray of seaweed extract and preparation method of nasal spray
  • Nasal spray of seaweed extract and preparation method of nasal spray

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Preparation of seaweed extract nasal spray

[0022] Prescription composition: seaweed polysaccharide 2g, glycerin 200g, sodium chloride 50g, and the rest is water for injection.

[0023] Preparation process: Take the prescribed amount of seaweed polysaccharide and add it into a sterilized container, add an appropriate amount of 300ml of sterilized water for injection treated with activated carbon, stir evenly until clear liquid, add an appropriate amount of moisturizing agent to dissolve, stir evenly, and then add the remaining After cooling 700 ml of water for injection, adjust the osmotic pressure to 285-310 (mOsm / kgH 2 O), filter, seal the filtrate and heat at 100°C for 30min, cool to room temperature, fill, and distribute in plastic spray bottles (12mL / bottle), to get ready. (Note: The mouth of the bottle is a special spray pump (spray system), including a sterile filter)

Embodiment 2

[0024] Example 2 Nasal spray properties, pH, minimum filling volume, and inspection of each spray volume

[0025] According to the preparation method of the embodiment, three batches of products were prepared, respectively 001, 002, and 003 batches, and their properties, pH value, filling volume, per spray volume, and uniformity were inspected.

[0026] Table 1 Inspection results

[0027] batch character PH value Loading ml Each injection volume μl / time 001 Transparent colorless viscous liquid 7.01 11.98±0.19 116.3±1.8 002 Transparent colorless viscous liquid 7.10 12.01±0.16 108.6±1.4 003 Transparent colorless viscous liquid 7.05 11.98±0.29 112.7±1.6

[0028] The nasal spray is a transparent, colorless liquid with a uniform solution and a neutral pH, and each spray dose contains a uniform amount of the main drug.

Embodiment 3

[0029] Example 3 Study on Stability of Seaweed Polysaccharide Nasal Spray

[0030] This product investigates the preparation of the solution under normal light conditions. The solution is placed under normal light conditions for 12 hours, and the absorbance, content and related substances are measured at 0, 4, 8 and 12 hours. The results are as follows:

[0031] The solution stability result prepared under the normal light condition of table 2

[0032]

[0033] It can be seen from the experimental results that the color, content and related substances of the seaweed polysaccharide nasal spray solution prepared under normal light conditions meet the requirements, and compared with 0h after being placed under normal light conditions for 12 hours, there is no obvious change in absorbance, content and related substances. Therefore, under normal light conditions, the prepared seaweed polysaccharide solution is stable.

[0034] Strong light exposure test Place the product hori...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
viscosityaaaaaaaaaa
Login to View More

Abstract

The invention relates to nasal spray of seaweed extract and a preparation method thereof. The content of active ingredient seaweed polysaccharide of the nasal spray in every millimeter of solution is 1mg-2.5mg; the content of glycerin in every millimeter of solution is 0.1mg-0.3mg; the content of sodium chloride in every millimeter of solution is 4.0mg-5.0mg. The preparation method of the nasal spray comprises the following steps of: sterilizing seaweed polysaccharide; adding injection water and humectants; uniformly stirring; adding the rest of injection water to adjust osmotic pressure; filtering, sterilizing, cooling and filling. The nasal spray disclosed by the invention is convenient to use; the preparation method is simple and easy to operate; the preparation is free of preservative, sterile, stable, capable of keeping nasal mucosa moist and capable of effectively preventing viral flu.

Description

Technical field [0001] The invention is the field of drug preparations, which involves nasal spray agents and preparation containing seaweed extracts as active ingredients. Background technique [0002] A variety of extracts of seaweed have antiviral activity. A Carraguard, a vaginal disinfection agent based on corner fork -based gum, can effectively inhibit HIV and other sexually transmitted diseases. It has entered the phase III clinical trial in South Africa.The extensive application and in -depth understanding of seaweed polysaccharides, people's research on seaweed polysaccharide biological activity is increasingly valued, and sulfuric acidized polysaccharides, including Kara gum, are known in the art due to their antiviral performance. [0003] Nasal virus (HRV) consists of at least 100 serum types, which is the main pathogenic medium for ordinary colds.Due to the large number of serum types, the development of vaccines has become a problem; therefore, antiviral agents may ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/12A61K31/715A61K31/726A61P31/16A61P31/14A61P31/20
Inventor 关屹闫冬
Owner LIAONING YILING KECHUANG BIOLOGICAL MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com