Application of maidenhair volatile oil in rhinitis resistance medicine

A technology of peacock grass and volatile oil, applied in drug delivery, drug combination, medical preparations containing active ingredients, etc., can solve the problems of ineffectiveness and poor curative effect of rhinitis

Inactive Publication Date: 2017-10-27
蔡德成 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, antihistamine drugs such as terfenadine or antiallergic drugs such as tranilast and ketotifen are mainly used in the treatment of rhinitis. These drugs have poor or ineffective effects on chronicity and recurrent rhinitis

Method used

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  • Application of maidenhair volatile oil in rhinitis resistance medicine
  • Application of maidenhair volatile oil in rhinitis resistance medicine
  • Application of maidenhair volatile oil in rhinitis resistance medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1: steam distillation method prepares malachite volatile oil

[0016] Take the whole herb of Peacock Herb, remove impurities, weigh 1kg, crush it, pass through a 20-mesh sieve, add 8L of tap water, extract by steam distillation for 3 hours, separate the volatile oil layer, add anhydrous sodium sulfate to dry, and obtain the volatile oil of Peacock Meadows. The yield was 0.17% (by weight).

Embodiment 2

[0017] Embodiment 2: steam distillation method prepares malachite volatile oil

[0018] Take the whole herb of Peacock Herb, remove impurities, weigh 1kg, crush it, pass through a 50-mesh sieve, add 10L of tap water, extract it by steam distillation for 6 hours, separate the volatile oil layer, add anhydrous magnesium sulfate to dry, and obtain the volatile oil of Peacock Grass. The yield was 0.20% (by weight).

Embodiment 3

[0019] Embodiment 3: Preparation of malachite volatile oil by carbon dioxide supercritical fluid extraction

[0020] Take the whole peacock herb, remove impurities, weigh 1kg, pulverize, and pass through a 60-mesh sieve. Turn on the power, turn on the cooling cycle and heating, set the temperature of the extraction cylinder to 30°C, the temperature of the separation tank I to 25°C, and the temperature of the separation tank II to 20°C. Put the malachite powder into the extraction tank and start the CO 2 Circulation system, set the flow rate to 10L / min. Adjust the pressure of the extraction cylinder to 15MPa, the pressure of the separation kettle I to 8MPa, and the pressure of the separation kettle II to 4MPa. When each parameter reaches the set value, start timing, and through 60min extraction, take out the volatile oil from the discharge port of the separation kettle I and the separation kettle II, to obtain the malaise volatile oil, and the extraction rate is 0.22% (weight...

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Abstract

The invention relates to application of maidenhair volatile oil in a medicine for treating rhinitis. A method comprises the step of grinding a whole herb of maidenhair and then extracting the maidenhair by a steam distillation method or a carbon dioxide supercritical fluid extraction method to form the volatile oil. No toxic reagent is used by the two extraction methods, and the extracted volatile oil has the characteristics of no toxicity, no residue, simple extraction technology and high extraction efficiency. A medicinal auxiliary material can be added into the volatile oil to prepare a nasal drop or a spray as the medicine for treating the rhinitis. Pharmacological experiments show that the volatile oil has a better pharmacological action on an allergic rhinitis model of a guinea pig, can obviously alleviate symptoms of a nose of the allergic rhinitis model of the guinea pig, reduces an ethological accumulative integral, and significantly relieves edema of a nasal mucosa of the allergic rhinitis model of the guinea pig.

Description

technical field [0001] The invention relates to a herbal medicine and its application, in particular to the medicine with malachite volatile oil as the active ingredient and its use in the preparation of anti-rhinitis medicine. Background technique [0002] Peacock grass (Tagetes patula L.), also known as red yellow grass, rattan chrysanthemum, and small marigold, is a plant of the genus Marigold in the Asteraceae family. It is an annual herb with a flowering period from July to September. It is cultivated all over our country and is a common ornamental flower. Peacock grass has medicinal and health care functions. The flowers and leaves can be used as medicine. Can treat whooping cough, tracheitis, cold and so on. [0003] Since the 1980s, people began to study the chemical constituents of Malachite, and isolated flavonoids such as patuletin, quercetagetin, and quercetagitrin ( State Administration of Traditional Chinese Medicine "Chinese Materia Medica" editorial board;...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61P11/02
CPCA61K9/0043A61K36/28A61K2236/331A61K2236/37
Inventor 蔡德成窦德强冉小库
Owner 蔡德成
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