59 results about "Molecular chemistry" patented technology

The invention belongs to the technical field of high-molecular chemistry and relates to a multiple sensitive hydrogel material and a preparation method thereof. The hydrogel material comprises a polymer with cyclodextrin (subject) and polyether pluronic modified by ferrocene (object) group. A gel formation method comprises steps of: simultaneously dissolving the polymer with cyclodextrin and the polyether pluronic with ferrocene group in water; and stirring and dispersing thoroughly under certain solution condition, so as to form a large amount of crosslinking netted organizations based on subject and object identification in the solution. The gel material can response to environment temperature change, oxidizing agent, existence of electric field or change of glucose concentration to generate gel-sol conversion. The invention has advantages of simple preparation method, environment-friendliness and thrift, and has huge application value in biomedicine.

The present invention provides one kind of nanometer micro gel prepared with protein and polysaccharide and its preparation process, and belongs to the fields of biochemistry, high molecular chemistry and medicine preparation. The nanometer micro gel is formed with two kinds of protein or one kind of protein and one kind of polysaccharide differently charged in the same pH conditioned, and through heating to denature protein. Differently charged protein and polysaccharide forms electrostatic composite, micelle or deposit, and through pH regulation and heating, nanometer micro gel in core-shell structure is obtained. The nanometer micro gel may have medicine or nutriment coated through coating / diffusion to obtain nanometer edible medicine or nutriment colloid. Or, it may have perfume, cosmetics or dye coated for releasing in special environment.

This invention belongs to chemistry pharmaceutical field and relates to a medication transfer system, especially relates to an agglutinin masked medication-load transfer mechanism transferring from nose to brain. This invention comprises medication carrier nanograin, vesicle or lipid body surface finish agglutinin. By using the transfer system, resort time of medication-load system on nasal mucosa can be prolonged, dielectric mucosa absorb the medication-load system and selectively deliver small molecular chemistry medication, diagnosis medication, polypeptide proteins and gene medication into brain. This invention can deliver more medication into brain and relatively decrease medication in outer tissue, so it can depress toxic action at every pore while toning up prevention, cure and diagnosis effect of backbone diseases.

The invention relates to a biosensor for detecting peptidylarginine deiminases, and a preparation method and application thereof. The sensor is characterized in that a polypeptide chain 1 (FGGGRGAC) is modified on the surface of a gold electrode; the sulfydryl of the cysteine at the end C of the polypeptide chain fixes the polypeptide chain 1 onto the surface of the electrode through a gold-sulfur bond; polypeptide chain 2 (FGGGGGC) functional silver nanometer particles are connected with silver nanometer particles through the sulfydryl of cysteine of the polypeptide chain 2. Under the assistance of the mutual action of supermolecule cucurbituril 8(CB[8]) assisted subject and object, the functional silver nanometer particles can be recognized with FGG at the end N of the polypeptide chain 1 and FGG at the end N of the polypeptide chain 2 due to CB[B]. The biosensor uses a super molecular chemistry assistance signal marking method for improving the experiment sensitivity; the linear range of the PAD4 can be detected to be 0.005 nM to 200 nM; the detection limit is 0.79 nM; the specificity is very high; the target and other reference protein can be effectively distinguished; the goal of detecting the activity of the endogenous PAD4 in the HL-60 lysates can be achieved.

The invention provides a carbazole-based high-condensed ring dinitrogen-aza[7]helicene compound (I) and a synthetic method thereof, belonging to the technical field of chemical industry. A high-condensed ring dinitrogen-aza[7]helicene compound with high solubility is prepared successfully by taking a cheap carbazole derivative with a plurality of active spots as a raw material by a photocatalysis loop closing method. The method has the advantages of high yield, short time, easiness for operating and the like; and moreover, the use of an expensive reagent is avoided, so that the preparation cost is reduced, and popularization and application are easy. The carbazole-based high-condensed ring dinitrogen-aza[7]helicene compound (I) is recrystallized in different solvents, so that an inclusion compound crystal comprising different solvents is obtained. The high-condensed ring dinitrogen-aza[7]helicene compound can be widely applied in the fields of super molecular chemistry, asymmetric catalysis, chiral liquid crystals, organic two-order nonlinearity, organic electroluminescence, biological medicine and the like.

The invention provides a bio-based adhesive and a preparation method thereof and belongs to the technical field of high-molecular chemistry. The bio-based adhesive contains the following main components in parts by weight: bio-based starch, lignin, tea polyphenol and isocyanate. The bio-based adhesive and the preparation method provided by the invention have the advantages that the traditional preparation method for the adhesives is changed, and under the condition without adding any organic solvent and aldehyde-containing monomer, the bio-based adhesive with higher adhesiveness and heat stability is prepared by adopting natural biomass starch as a main agent, the lignin and the tea polyphenol as additives, the isocyanate as a crosslinking agent and water as a green solvent as well as a series of environment-friendly paths.

A method for post-treatment of polymer emulsions belongs to the field of high-molecular chemistry and includes the steps of acidifying polymer powder in an acidic solution, and neutralizing the polymer powder in an alkaline solution to prepare polymer resin, wherein the polymer powder is prepared by pre-drying and granulating a polymer emulsion. Through the acid pickling, residual various small-molecular impurities in the polymer powder are removed, so that the prepared granules have excellent appearance. The residual acid then is neutralized so that the polymer resin can be stored for a long time without color change. The method is high in yield, is high in product qualified ratio, and has simple processes and low production cost. The invention also provides a device for the post-treatment of the polymer emulsions, wherein the device is provided with, continuously, a granulation column and a neutralization tank, wherein a drying chamber and an acid-pickling chamber are arranged in the granulation column. The method and the device ensure continuous operation of the steps of granulation, acidification and neutralization, avoid product loss due to replacement of equipment and also increase yield.

The invention discloses a preparation method of synergistic flame-retardant polyol and application and belongs to the technical field of high-molecular chemistry, reaction-type flame-retardant agent and building insulation materials. The synergistic flame-retardant polyol is prepared by the following steps: using phosphorus pentoxide to react with water, generating phosphoric acid, and then reacting with epichlorohydrin, paraformaldehyde, isocyanuric acid and melamine. The synergistic flame-retardant polyol is used for preparing flame-retardant polyurethane foam materials.

The present invention discloses a method for predicting the chemical absorption property of MgO nano-cluster surface vapor state deposition transition metal Au and Pt in absorbing CO molecules. The B3LYP method of the density functional theory (DFT) is effectively used to perform structural optimization on the following models of an absorption system: A: Mg909 / Au / CO model, B: Mg909 / Pt / CO model, C: Mg908 / Au / CO model and D: Mg908 / Pt / CO model. Output information comprising bond lengths, bond angles, dihedral angles, adsorption energy, front lines and the like can be simulated more conveniently and rapidly by using a computer, so that interference from other substances can be avoided, thereby acquiring calculated simulation data values more accurate than experimental data; absorption energy values in a series of absorption systems can be acquired to predict the absorption capability of the absorption system with respect to CO molecules; and structural optimization of future nano-MgO materials is performed, to enable the future nano-MgO materials to have advantages of a high adsorption rate, quick response, a large adsorption capacity and the like, and play important roles in environmental protection and resource conservation.

The invention relates to the field of organic high-molecular chemistry and discloses an N-heterocyclic carbene platinum complex metal carboxylate integrated catalyst and a preparation method thereof. The preparation method includes following steps: (1) carrying out a reaction between alkyl imidazole and halogenated carboxylic acid to obtain a carboxylic acid functionalized imidazolium salt; (2) carrying out a reaction with chlorides of ferrous, copper, zinc, calcium or magnesium to obtain a imidazole-based ionic liquid containing carboxylates containing the ferrous, the copper, the zinc, the calcium or the magnesium; (3) preparing an N-heterocyclic carbene ligand from the ionic liquid under effect of potassium tert-butyl alcohol; and (4) carrying out a reaction with a Karstedt catalyst to prepare the N-heterocyclic carbene platinum complex metal carboxylate integrated catalyst. The catalyst is high in selectivity, is free of generation of platinum black precipitation, is easy to separate and can be recycled.

The invention belongs to the technical field of super-molecular chemistry and particularly relates to small molecule peptide-based cholesteric organic gel molecules and a preparation method thereof. The cholesteric organic gel molecules can form gel in an organic solvent and the formed gel has thermal stability and water stability and can respond to ultrasound for realizing transformation of ultrasonically-induced gel into gel. The organic gel molecule comprises 1) an anhydride naphthalene part serving as a luminophor, 2) a middle small peptide serving as a functional group for forming intermolecular hydrogen bonds and 3) a sterides part which has biocompatibility and serves as a gelation factor and a hydrophobic group. The molecule can form high-quality gel which has rich micro-nanoscale macro morphologies, such as nuclear shells, solid balls, defect balls, nanofiber, micro-fiber and the like, and has regular shape and high repeatability in nearly ten organic solvents including acetonitrile, ethanol, benzene, toluene, acetone and the like through a sol-gel process. The organic fluorescent gel has a certain application value in the aspects of nano material preparation, medicinal carrier transportation, biological marking and the like.

The present invention relates to the field of organic and high-molecular chemistry, and discloses a preparation method of substituted diaryl phosphate. It is characterized by that said invention uses substituted phenol or substituted diaryl bisphenol as raw material, in the presence of inorganic alkali and non-toxic solvent said invention makes three steps of phenol treatment, condensation reaction and direct alkali-adding aqueous solution salt formation be implemented in one reaction container.

The invention belongs to the technical field of super molecular chemistry, and particularly relates to L-glutamine organogel containing 1-cyanotoluylene and a preparation method thereof. The organogel is a mixed system consisting of an organogel agent and a solvent. In the system, the organogel agent is L-glutamine organogel containing 1-cyanotoluylene, and the concentration of gel is 1-5 milligrams / milliliter. The organogel is obtained by dissolving a small molecular organogel agent in an organic solvent or a mixture of an organic solvent and water under a heating condition and cooling to room temperature. The organogel can be used for gelating 12 types of solvents such as toluene, chlorobenzol, dichlorobenzene, methylene dichloride, methanol, a mixture of DMSO (Dimethylsulfoxide) or DMF (Dimethyl Formamide) and water, and the like, and the system represents an aggregation induction fluorescence enhancement phenomenon in the gelating process. Due to the aggregation induction fluorescence enhancement property, the application of the L-glutamine organogel to a temperature-sensitive fluorescent switch becomes possible.

The present disclosure provides an improved device that can be used to sense and characterize a variety of materials. The device may be used for a variety of applications, including genome sequencing, protein sequencing, biomolecular sequencing, and detection of ions, molecules, chemicals, biomolecules, metal atoms, polymers, nanoparticles and the like.

The invention discloses a magnetic putamen MOFs compound drug-loading system of pillararene nano-valve controlled-release, a preparation method and an application thereof, and belongs to the technicalfield of the compound drug-loading system. The preparation method comprises the following steps: using Fe3O4 as a nuclear matrix, enabling MOFs reaction mother solution to directly react with the nuclear matrix through an in-situ growth mode to form the magnetic putamen MOFs, and modifying 'connecting shaft' molecules on the magnetic putamen MOFs material loaded with the drug through a post-modification mode and performing the follow-up installation of the pillararene nano-valve mediated by a subjective and objective acting force, and realizing the controlled-release under the stimulation oflesion environment factors. Through changing the types of the pillararene nano-valve and the 'connecting shaft' molecules, the slow release of the drugs under the stimulation response can be realized.The whole compound material diagnosis and treatment system is capable of realizing the targeting drug release and the controllable drug release behavior by using the controllability of the nano-valveas the opportunity. The multi-functional point-fixing, timing and positioning treatment can be realized by organically combining the molecular chemistry and the material chemistry, so the disease treatment efficiency is improved.

The invention, which relates to the micro-nano Newton force detection technology field, discloses a system and a method for detection of a micro-nano Newton force on a spherical membrane vibratory quantum. According to the method, under an effect of spherical membrane vibration, on the basis of changes of a diameter and a thickness of a spherical membrane, detected vibratory quantum change information enables detection on a micro-nano Newton force exerted on a spherical membrane to be realized. The system comprises a micromanipulator platform, a corpuscule loading mechanism, a spot light source, a PSD sensor, a data processing system and the like. In addition, the system also comprises a one-time spherical membrane generation mechanism or a spherical membrane support that is used for a repeated spherical membrane. According to the invention, enormous economic benefits and technological supports are brought for micro-force detection fields like biomedicine and molecular chemistry and the like in China.

A method for preparing a supra-molecular graphene load manganese dioxide self-assembly relates to the technical field of supra-molecular chemistry. According to the invention, the electrochemical performance of a graphene-based super capacitor is improved by combining the properties of a manganese dioxide Faraday capacitor and high specific surface area and high conductivity of graphene. Graphene-manganese dioxide compound is simply and rapidly prepared through supra-molecular interaction; then, graphene is assembled through supra-molecular interaction; and finally, a three-dimensional self-assembly of graphene sandwich manganese dioxide nanoparticles is obtained. Experiments show that the self-assembly of graphene load manganese dioxide has higher specific capacitance than that of pure manganese dioxide, and the specific capacitance can be up to 867.8 Fg<-1>.

The invention discloses a method and a system for detecting an optical micro / nano Newton force on a spherical membrane and relates to the technical field of micro / nano Newton force detection. The method realizes the detection a micro / nano Newton force applied on the spherical membrane through the detection of the variable quantity of an interference spectrum obtained by changing the diameter and thickness of the spherical membrane under the interference effect of the spherical membrane. The system comprises a micro operating platform, a micro particle loading mechanism, a point light source, an optical fiber sensor, a spectrum analyzer, a data processing system and other large parts. The system also comprises a disposable spherical membrane generating mechanism or a reusable spherical membrane support. The method and the system can bring huge economic benefits and technical support to the micro force detection fields such as biochemical fields, molecular chemistry fields and the like in China.

The invention provides a synthesis method of a free radicalized ethylene-maleic anhydride copolymer, and belongs to the field of functional high molecular chemistry. An esterification reaction is performed on an ethylene-maleic anhydride copolymer and 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine nitroxide free radicals to obtain the free radicalized ethylene-maleic anhydride copolymer. By the synthesis method, a previous method for preparing a free radicalized polymer by relying on complex and cumbersome monomer polymerization is broken through, only one step of simple esterification reaction isneeded, and the prepared free radicalized ethylene-maleic anhydride copolymer has high molecular weight and relatively high free radical content of per unit mass of repeating units, and the free radical number of each monomer molecule can be as high as 0.97; the electrolyte resistance is good, and the solubility in an electrolyte solution is only 0.59mg / mL; meanwhile, the synthesis method has theadvantages of simple reaction, mild condition, and high reaction degree which can reach 54%.

The invention relates to the technical field of friction welding stirring heads, and discloses a sialon ceramic friction welding stirring head and a production method thereof. The friction welding stirring head is creatively produced from sialon ceramic, the sialon ceramic has good toughness, very high hardness, very high wear resistance and very high high-temperature oxidation resistance, and raw materials of the sialon ceramic have low prices and wide sources. A traditional ceramic technology and high-molecular chemistry are organically combined, a high-molecular polymer polymerization technology is introduced to a ceramic production technology, and a gel injection molding technology is adopted, so compared with other molding technologies, the method disclosed in the invention has the substantial advantages of short production time, low die and device requirements, low cost, and high structure and component designability; the density of the above product is uniform; a green body has a high strength, and is convenient for machining; and the method is especially suitable for realizing near-net-shape forming, realizes small product shape limitation, can be used to produce complex profiled parts, and is universal and economic.

The invention discloses extraction equipment for detecting a high-molecular chemical reagent and an extraction process thereof.The extraction for detecting the high-molecular chemical reagent is carried out by adopting a multi-station design concept, and an arranged clamping mechanism can be used for clamping glass tubes loaded with reagents and having different sizes; an arranged extraction mechanism can realize synchronous extraction and automatic mixing of various reagents, so that the overall operation efficiency can be greatly improved; and meanwhile, single glass tubes and the mixed reagents can be subjected to centrifugal stirring treatment, so that the phenomena of chromatography and the like of the reagents are avoided, and the mixing speed and uniformity of the mixed reagents are improved.

The design and deposition of a sensing layer for room temperature SAW / BAW chemical sensors utilizing macrocyclic compounds in accordance with supra-molecular chemistry principles. The gas to be sensed is attached to the organic sensing film thus changing its visco-elastic properties and creating a mass increase of the film deposited on the surface of SAW / BAW devices. A direct printing method can be used as an additive, mask-less procedure to deposit metallic interdigital transducers and electrodes required for SAW / BAW devices, along with the deposition of a guiding layer and the organic films only on the location required by the sensing SAW / BAW principle of the sensor. Different thermal treatment solutions can be used for the consolidation of the gelly organic films deposited by the direct printing methods.

The invention discloses a method for preparing a nanometer channel with molybdate nanowires, belonging to the nanometer technical field. The method comprises the following steps: a) preparing molybdate nanowires; b) dispersing the nanowires on a substrate; c) preparing the wall material of the nanometer channel on the substrate, wherein the wall material of the nanometer channel covers the nanowires; and d) dissolving the nanowires with the designated polar solvent to obtain the nanometer channel. The invention can be used to prepare the nanometer channel and has wide application prospect in local chemical analysis, local physical measurement, heat engineering, disease detection, cell screening, molecular chemistry test, mRNA extraction and passivation, protein crystallization and other aspects.

The invention provides a three-dimensional reconstruction method for indoor toxic and harmful gas concentration based on basic theories of geometric mathematics, optical physics and molecular chemistry. The method mainly comprises the steps of collecting monitoring point data, identifying abnormal data, discretizing a measured area, performing two-dimensional horizontal reconstruction and performing three-dimensional space reconstruction. At least four poisonous and harmful gas detection devices are installed on an indoor top plate, and monitoring point data of the poisonous and harmful gas detection devices are collected; a space coordinate system of the measured area is built; the measured area is divided into a vertex, a side boundary, a plane area and a space area; the measured area isuniformly discretized; a weight vector and a gas concentration vector are constructed by discretizing the number of grids, and two-dimensional reconstruction on the gas concentration of the measuredarea is carried out; a concentration coefficient function is constructed, a three-dimensional gas concentration map in a three-dimensional space is accurately reconstructed, and the method can be widely applied to three-dimensional online monitoring of indoor space gas distribution.

The invention belongs to the technical field of data synthesis, and particularly relates to a molecular optimization method and system, terminal equipment and a readable storage medium. When the chemical structure of a target molecule is complex, an existing system is poor in performance. The invention provides a molecular optimization method, and the method comprises the steps: obtaining a sourcemolecule, carrying out the cutting of the source molecule according to a target molecule, and obtaining a source molecule reserved region which is a common molecular substructure of the source molecule and the target molecule; converting the source molecule into a simplified molecule linear input specification character string, wherein the simplified molecule linear input specification characterstring is a non-common molecule substructure part in the target molecule; and splicing the source molecule reserved region and the simplified molecule linear input specification character string to obtain the target molecule. The system error rate is greatly reduced.

The invention discloses a programmed algorithm for simulating molecular chemical trend motion, which comprises the following steps of: establishing a finite element model related to receptor and ligand cross diffusion, and strictly deducing an analytical equation for unifying molecular chemotaxis behaviors from a statistical thermodynamics basic framework; developing a core algorithm capable of deducing the special motion process, flow field configuration and fluid properties serving as input parameters, giving numerical simulation to the molecular chemotaxis system, and using the molecular chemotaxis system for predicting and checking experiment results. According to the method, the first principle is followed, a dominance equation for describing molecular chemotaxis is completely derivedfrom the basis of a basic statistical thermodynamics theorem, trial mathematical expression and empirical parameter definition are not needed, and a general model is established; a motion equation isconverted into a core algorithm of a program, the motion trend and related effects of a specific molecular binding system are efficiently simulated on the basis of the properties of an actual system,and a quantitative prediction result is output and used for data mining and comparison.

The invention belongs to the technical field of high-molecular chemistry synthesis, and particularly relates to a method for one-kettle preparation of a fluorosilicone block polymer-modified inorganic material. Activators regenerated by electron transfer for atom transfer radical polymerization are adopted to control a reaction, the concentration of a metal catalyst in a system is extremely low, side reactions between radicals and the catalyst and between the radicals can be effectively inhibited or reduced, and end group activity is better kept. Surface functionalized inorganic particles are used as an initiator, a first monomer and a reducing agent are added, and polymerization is initiated; and when the first monomer conversion rate is relatively high, a second monomer and the reducing agent are added and one-kettle preparation of the fluorosilicone block polymer-modified inorganic material can be achieved. The invention provides the technology of one-kettle preparation of the fluorosilicone block polymer-modified inorganic material, wherein the technology has the advantages of being low in catalyst concentration, mild in reaction conditions, simple in operation steps and suitable for industrialization. At the same time, the method has important significance in preparation of high-efficiency marine antifouling coatings, improvement of marine fishery industries, and even enhancement of naval power.

The invention discloses a grinding device of high molecule chemical material particles. The grinding device of the high molecule chemical material particles comprises a fixed bottom plate, wherein a grinding cylinder is fixedly connected with the middle of the upper surface of the fixed bottom plate, a fixed plate is fixedly connected with the middle of the lower surface of the fixed bottom plate,a fixed frame is fixedly connected with the lower surface of the fixed plate, and a telescopic air cylinder is fixedly connected with the bottom of the fixed frame. According to the grinding device of the high molecule chemical material particles, the telescopic air cylinder, a piston fixing plate, a spring, a support shaft, a grinding plug opening, an arc grinding shaft, a top cover plate, a fixed plate block, a grinding motor, a rotation shaft and a grinding handle are cooperatively arranged, and then in the use process, the chemical material particles can be ground by starting the grindingmotor so as to achieve uniform grinding effect, the grinding plug opening is enabled to rise and fall by starting the telescopic air cylinder, the chemical material particles after being ground are enabled to fall to the position below the grinding plug opening when the grinding plug opening falls to the bottom, and then grinding efficiency of the grinding device of the high molecule chemical material particles is improved.

The invention relates to the field of high-molecular chemistry and especially relates to a crosslinking agent, a preparation method and an application thereof, and a CO2-responding polymer formed by the crosslinking agent. The crosslinking agent is a compound represented as the structure formula (I) and has the two functional groups including a methacryloyl group and a diethylamine group at the same time, so that on one hand, the methacryloyl group, as a crosslinking chemical group which acts on a hydroxyl group in polyvinyl alcohol, can form a polymer with the polyvinyl alcohol as a frame in a crosslinking manner, and on the other end, the diethylamine group acts on CO2 to form a polymer which serves as the CO2-responding polymer.