Agglutinin-modified drug delivery system from nose to brain

A delivery system and lectin technology, applied in the field of chemical pharmaceuticals, can solve the problems of non-specificity and location, unsatisfactory residence time, increase the absorption of drug carriers, etc., so as to increase the amount of brain entry, reduce the effect of treatment and diagnosis, and reduce the Effects of systemic toxicity
CN1839799AInactive Publication Date: 2006-10-04FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2006-10-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention belongs to chemistry pharmaceutical field and relates to a medication transfer system, especially relates to an agglutinin masked medication-load transfer mechanism transferring from nose to brain. This invention comprises medication carrier nanograin, vesicle or lipid body surface finish agglutinin. By using the transfer system, resort time of medication-load system on nasal mucosa can be prolonged, dielectric mucosa absorb the medication-load system and selectively deliver small molecular chemistry medication, diagnosis medication, polypeptide proteins and gene medication into brain. This invention can deliver more medication into brain and relatively decrease medication in outer tissue, so it can depress toxic action at every pore while toning up prevention, cure and diagnosis effect of backbone diseases.
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Description

technical field

[0001] The invention belongs to the field of chemical pharmacy and relates to a drug delivery system, in particular to a lectin-modified drug delivery system through the nose into the brain. technical background

[0002] The blood-brain barrier (BBB) ​​is a layer of barrier system between blood and brain tissue. It is composed of polarized brain capillary endothelial cells through complex intercellular tight junctions. It is very important for maintaining the relative stability of the brain environment. , but it is also the main barrier for drugs to enter the brain tissue for prevention, treatment and diagnosis.

[0003] In order to achieve drug delivery in the brain, a variety of brain targeted drug delivery strategies have been applied, such as drug esterification modification and chemical delivery system, carrier, receptor and adsorption-mediated brain targeted drug delivery system, nasal cavity medication etc. Among them, only nasal administration is a ...

Claims

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