Controlled-release antibacterial dressing and preparation method thereof

A technology of antibacterial agent and antibacterial composition, applied in the field of slow-release antibacterial dressing and its preparation

Pending Publication Date: 2018-07-03
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the production of medical dressings in China is mainly concentrated on traditional medical dressings, and few new medical dressings are involved.

Method used

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  • Controlled-release antibacterial dressing and preparation method thereof
  • Controlled-release antibacterial dressing and preparation method thereof
  • Controlled-release antibacterial dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0094] Embodiment 1: Preparation of drug-loaded starch microsphere antibacterial dressing

[0095] (1) Preparation of starch microspheres embedded with polyhexamethylbiguanide hydrochloride (PHMB)

[0096] Pour 50 mL of mixed solution of cyclohexane and chloroform (V (cyclohexane): V (chloroform) = 4: 1) into a 250 mL three-necked flask as the oil phase, and add 2 g of emulsifier (where the emulsifier The mass ratio of Span60:Tween60=3:2), heating and stirring at 50° C. to completely dissolve the emulsifier, and set aside.

[0097] Weigh 1.5 g of soluble starch into 15 mL of distilled water, heat and dissolve to prepare starch=10wt% aqueous solution. Measure 10mL of the starch aqueous solution and add 0.2g MBAA (N,N'-methylenebisacrylamide), fully dissolve and add dropwise to the above oil phase, keep stirring at 500r / min, and take samples under an optical microscope in due course Observe the shape of the emulsion. After formation of uniform droplets, 0.1 g of ceric ammoniu...

Embodiment 2

[0105] Embodiment 2: the antibacterial effect of drug-loaded starch microsphere antibacterial dressing on Escherichia coli E.C (ATCC25922) and Staphylococcus aureus S.a (ATCC6538)

[0106] (1) Antibacterial test

[0107] Cut the sample into a size of 1.0cm×1.0cm, put it into a 250ml Erlenmeyer flask, add 70ml of PBS and 5ml of bacterial suspension, and adjust the concentration of bacterial suspension in PBS to 1×10 4 -9×10 4 CFU / ml, fix the Erlenmeyer flask on a vibrating shaker, shake it at 150r / min for 24h, take the sample solutions of the experimental group (with sample) and the blank group (without sample), respectively, dilute with PBS appropriately, and pour it into agar Plates were inoculated for colony counting. At the same time, a control group should be set up, and only PBS and bacterial suspension should be added to the control group. The antibacterial rate is the ratio (in percentage) of the difference between the average number of colonies before and after shak...

Embodiment 3

[0112]The long-acting antibacterial test of embodiment 3 drug-loaded starch microsphere antibacterial dressings to E.C and S.a

[0113] Test method is with reference to embodiment 2, and drug-loaded starch microsphere antibacterial dressing is to E.C and S.a long-acting antibacterial test, and drug-loaded starch microsphere composition is to E.C and S.a antibacterial action test result as shown in table 2 and table 3:

[0114] "+" indicates that it has antibacterial effect on bacteria,

[0115] "-" indicates that there is basically no antibacterial effect or weak antibacterial effect on bacteria.

[0116] Table 2 Long-acting antibacterial test of drug-loaded starch microsphere antibacterial dressings on E.C and S.a

[0117] value

symbol

＞80

+++

60

++

50

+

40

―

30

――

20

―――

[0118] The antibacterial ef...

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Abstract

The invention relates to a controlled-release antibacterial dressing and a preparation method thereof and particularly discloses a compound. The compound contains a dressing carrier and microspheres loaded to the dressing carrier. The invention further discloses a composition, a dressing as well as a preparation method and use of the dressing. According to the composition and the dressing, the pharmaceutical burst release phenomenon of a common antibacterial dressing can be effectively improved, and the growth and reproduction of germs such as escherichia coli, staphylococcus aureus, pseudomonas aeruginosa and Candida albicans can be steadily inhibited for a long time. The controlled-release antibacterial dressing provided by the invention is applicable to the treatment of operation cuts,wounds, burns, donor sites, pressure sores, diabetic ulcer and other wound surfaces.

Description

technical field [0001] The invention relates to the field of medical dressings, in particular to a slow-release antibacterial dressing and a preparation method thereof. Background technique [0002] Medical dressing products are an important class of medical supplies. At present, the production of medical dressings in China is mainly concentrated on traditional medical dressings, and few new-type medical dressings are involved. [0003] Wounds are prone to infection, mainly due to the reproduction of pathogens such as Staphylococcus aureus, Escherichia coli and Candida on the wound. Medical dressings are a key material in clinical wound management. The main function of traditional medical dressings is to cover wounds and prevent wound infection. With the development of modern science and technology, new medical dressings are constantly appearing, and the clinical efficacy is also improving. Compared with traditional dressings, new medical dressings, especially antibacter...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/44
CPCA61L15/44A61L2300/622A61L2300/602A61L2300/404
Inventor 项灵超李娟吴爱国
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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