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Amoxicillin capsule and preparation method thereof

A technology of amoxicillin capsules and amoxicillin, applied in the field of western medicine preparations, can solve the problems of large individual differences in capsule dissolution, reducing the effect of co-solvent and co-solvent, and increasing the relative amount of co-solvent added. release effect, volume reduction effect

Inactive Publication Date: 2018-06-29
ZHENGZHOU HOUYI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Invention patent CN103735529A discloses a method for preparing amoxicillin dry granulation capsules. Dry granulation is adopted, and cross-linked povidone is added as a disintegrant during the granulation process. The addition of cross-linked povidone will cause capsules There are large individual differences in dissolution. In addition, crospovidone may also reduce the solubilizing effect of the co-solvent, and increase the relative addition of the co-solvent in a disguised form.

Method used

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  • Amoxicillin capsule and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] An amoxicillin capsule is prepared from the following raw materials in parts by weight: 200 parts of amoxicillin, 5-10 parts of sodium carboxymethylcellulose, 1-1.5 parts of talcum powder and 0.5-3.5 parts of magnesium stearate.

[0027] It is prepared from the following raw materials in parts by weight: 200 parts of amoxicillin, 8 parts of sodium carboxymethylcellulose, 1.25 parts of talcum powder and 2 parts of magnesium stearate.

[0028] The amoxicillin is amoxicillin heavy powder granules obtained by dry granulation, and the particle size of the amoxicillin heavy powder granules is less than 20 mesh.

[0029] 70%-98% of the amoxicillin heavy powder granules have a particle size of 20-80 mesh, and 2%-30% of the amoxicillin heavy powder granules have a particle size of less than 80 mesh.

[0030] The particle size range of 50%-70% amoxicillin heavy powder particles is between 20-50 mesh, the particle size range of 15-30% amoxicillin heavy powder particles is between ...

Embodiment 2

[0040] An amoxicillin capsule is made of the following raw materials in parts by weight: 200 g of amoxicillin, 5 g of sodium carboxymethylcellulose, 1 g of talc, and 0.5 g of magnesium stearate.

[0041] The particle size range of 50% amoxicillin heavy powder granules is between 20-50 mesh, the particle size range of 25% amoxicillin heavy powder granules is between 50-80 mesh, and the particle size range of 25% amoxicillin heavy powder granules is The particle size is less than 80 mesh.

[0042] A kind of preparation method of above-mentioned amoxicillin capsule, concrete steps are as follows:

[0043] (1) Mix amoxicillin and talc evenly;

[0044] (2) The mixture obtained in step (1) and the dry inert gas are injected into the ultrafine pulverizer together, and crushed by high-speed airflow, and the obtained particles are passed through 500 sieves;

[0045] (3) Mix the fine powder obtained in step (2) with sodium carboxymethylcellulose evenly, pass through a 20-mesh sieve, m...

Embodiment 3

[0051] An amoxicillin capsule is made of the following raw materials in parts by weight: 200 g of amoxicillin, 5.5 g of sodium carboxymethylcellulose, 1.05 g of talc, and 0.8 g of magnesium stearate.

[0052] 52% of amoxicillin heavy powder granules have a particle size range of 20-50 mesh, 26% of amoxicillin heavy powder granules have a particle size range of 50-80 mesh, and 22% of amoxicillin heavy powder granules The particle size is less than 80 mesh.

[0053] A kind of preparation method of above-mentioned amoxicillin capsule, concrete steps are as follows:

[0054] (1) Mix amoxicillin and talc evenly;

[0055] (2) The mixture obtained in step (1) and the dry inert gas are injected into the ultrafine pulverizer together, and crushed by high-speed airflow, and the obtained particles are passed through 500 sieves;

[0056] (3) Mix the fine powder obtained in step (2) with sodium carboxymethylcellulose evenly, pass through a 20-mesh sieve, make wet granules, dry, and then pa...

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Abstract

The invention discloses an Amoxicillin capsule which is prepared from the following raw materials in parts by weight: 200 parts of Amoxicillin, 5-10 parts of sodium carboxymethylcellulose, 1-1.5 partsof talcum powder and 0.5-3.5 parts of magnesium stearate. Compared with the prior art, the Amoxicillin capsule is enabled to have higher dissolution rate through regulating the particle sizes of Amoxicillin particles as raw materials and the proportion of auxiliary materials, the use of carboxymethyl starch, cross-linked polyvinylidone and other disintegrating agents is avoided, the size of the Amoxicillin capsule is reduced, and the raw materials and the auxiliary materials can be held by using a No. 1 capsule; the process steps of the Amoxicillin capsule are simplified, the production costis reduced, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of western medicine preparations, in particular to an amoxicillin capsule and a preparation method thereof. Background technique [0002] The molecular formula of amoxicillin is C 16 h 19 N 3 o 5 S . 3H 2 O, molecular weight 419.46, amoxicillin is off-white or white powder, crystalline, slightly bitter taste, insoluble in ethanol, slightly soluble in water. [0003] Amoxicillin is one of the most commonly used semi-synthetic penicillin-type broad-spectrum R-lactam antibiotics, which is stable under acidic conditions and has a gastrointestinal absorption rate of 90%. Amoxicillin has a strong bactericidal effect and a strong ability to penetrate cell membranes. It is one of the most widely used oral semi-synthetic penicillins. After oral administration, the endophthalmium group in the drug molecule is immediately hydrolyzed to form a peptide bond, which is quickly combined with the transpeptidase in the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/43A61K47/38A61K47/02A61K47/12A61P31/04
CPCA61K9/4866A61K9/485A61K9/4858A61K31/43
Inventor 王凯李建正马沛然李亚娥
Owner ZHENGZHOU HOUYI PHARMA
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