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Propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel and preparation method thereof

A technology of in-situ gel and chitosan, which is applied in the directions of pharmaceutical formulations, unknown raw materials, medical preparations with inactive ingredients, etc., can solve the problems of unsatisfactory local administration methods, affecting the application of propolis, and difficulty in propolis.

Inactive Publication Date: 2013-02-13
KUNMING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, propolis is insoluble in water, and the local administration method is not ideal, which affects the clinical application of propolis

Method used

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  • Propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel and preparation method thereof
  • Propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel and preparation method thereof
  • Propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel and preparation method thereof

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Embodiment Construction

[0041] 1 Preparation and determination of chitosan with different degrees of deacetylation

[0042] (1) Preparation of chitosan with different degrees of deacetylation

[0043] Take 1g of chitosan with a deacetylation degree of 90% and dissolve it in 60mL of 12% (v / v) acetic acid solution, then add 60mL of anhydrous methanol, and add acetic anhydride according to the ratio in Table 1 below. The reaction time is,

[0044] Table 1 Preparation of chitosan with different degrees of deacetylation

[0045]

[0046] Add 500 mL of 0.5 mol / L potassium hydroxide-ethanol solution to precipitate a white fibrous substance, wash it twice with absolute ethanol until the solution becomes neutral, filter, and dry to constant weight to obtain chitosan with low deacetylation degree. By changing the amount of acetic anhydride added and adjusting the reaction time, chitosan with deacetylation degrees of 60%, 70%, and 80% was prepared. The degree of deacetylation of chitosan was determined by ...

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Abstract

The invention provides propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel and a preparation method thereof, and belongs to a preparation method for a periodontal treatment local slow-release medicament. The gel comprises a blank matrix thermo-sensitive in-situ gel of a chitosan acetic acid solution and an aqueous solution of beta-sodium glycerophosphate in a volume ratio; and an aqueous solution of propolis-coated hydroxypropyl beta-cyclodextrin in a mass ratio is used as a slow-release micro capsule of propolis / hydroxypropyl beta-cyclodextrin. The invention also provides the preparation method of the propolis and chitosan periodontal slow-release thermo-sensitive in-situ gel. Preferably, the chitosan of which the deacetylation degree is 90 percent and the molecular weight is 0.5 million Doyle is used as a medicament-carrying slow-release gel preparation. The gel forming temperature of the thermo-sensitive gel is 36 DEG C, the gel forming time is 65 seconds, the gel is released slowly and stably, the release degree reaches over 99 percent in 24 hours at the temperature of 37+ / -0.5 DEG C, and a sudden release effect is avoided.

Description

technical field [0001] The invention belongs to the preparation method of local slow-release medicine for periodontal disease treatment, in particular to the method for preparing periodontal slow-release medicine with temperature-sensitive in-situ gel. Background technique [0002] In the field of oral treatment, there are related research and clinical reports on propolis at home and abroad. In 1997, Yong et al. found through research that propolis had a significant inhibitory effect on oral pathogenic bacteria and enzyme activity. In 2007, Bruschi et al. reported the use of propolis sustained release agent to treat periodontitis. Preliminary studies have shown that this system has potential for treating periodontitis. The role of Zhouyan is worthy of clinical evaluation. In 2008, Jiang Lin and others studied the effect of propolis and propolis ornidazole mixture on the growth of Porphyromonas gingivalis, and found that propolis has a better effect on the growth of Porphyrom...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/36A61K47/40A61K35/64A61P1/02A61K35/644
Inventor 丁仲鹃税艳青李宝才孙剑
Owner KUNMING MEDICAL UNIVERSITY
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