Chitin tetra ammonium salt nano-particle, its preparation method and use
A technology of chitosan quaternary ammonium salt and nano-particles, which is applied in pharmaceutical formulations, medical preparations of non-active ingredients, powder delivery, etc., and can solve problems such as inability to apply sensitive macromolecules, failure to meet requirements well, and reduction , to achieve high encapsulation rate, meet environmental protection requirements, and good slow-release effect
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Embodiment 1
[0012] Embodiment 1: making concentration of chitosan quaternary ammonium salt is 1.6mg / ml aqueous solution, then model drug bovine serum albumin is dissolved in chitosan quaternary ammonium salt solution, bovine serum albumin concentration is 1.5mg / ml; Then Add 2ml of 0.5mg / ml sodium tripolyphosphate aqueous solution into 5ml of chitosan quaternary ammonium salt solution, and generate nanoparticles under stirring conditions at room temperature. The encapsulation efficiency of nanoparticles to bovine serum albumin reaches 77%, and in normal saline, the cumulative sustained release reaches 52% in six days.
Embodiment 2
[0013] Embodiment 2: the chitosan quaternary ammonium salt is made into a concentration of 1.0mg / ml aqueous solution, and then the model drug bovine serum albumin is dissolved in the chitosan quaternary ammonium salt solution, and the bovine serum albumin concentration is 0.8mg / ml; then Add 2ml of sodium tripolyphosphate aqueous solution with a concentration of 0.8mg / ml into 5ml of chitosan quaternary ammonium salt solution, and generate nanoparticles under stirring conditions at room temperature. The encapsulation efficiency of nanoparticles to bovine serum albumin is up to 89%, and in normal saline, the accumulated slow release reaches 29% in six days.
Embodiment 3
[0014] Embodiment 3: making concentration of chitosan quaternary ammonium salt is an aqueous solution of 1.6mg / ml, then the model drug bovine serum albumin is dissolved in chitosan quaternary ammonium salt solution, bovine serum albumin concentration is 1.0mg / ml; then Sodium alginate (concentration of sodium alginate is 0.5mg / ml) and sodium tripolyphosphate (concentration of sodium tripolyphosphate is 0.3mg / ml) aqueous solution that is dissolved in 2ml is added in the chitosan quaternary ammonium salt solution of 5ml, Nanoparticles were generated under stirring conditions at room temperature. The encapsulation efficiency of nanoparticles to bovine serum albumin reaches 17.5%, and in normal saline, the cumulative sustained release reaches 32% in six days.
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