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Improved Zhenyuan tablet and preparation method thereof

A technology of vibrating source tablets and tablet cores, which is applied in the field of improved vibrating source tablets and its preparation, can solve the problems of low bioavailability, achieve the effects of prolonging the sustained release time, improving bioavailability, good moisture resistance and moisture absorption

Inactive Publication Date: 2020-01-24
HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The active ingredient of Zhenyuan Tablets is total ginsenosides, but the bioavailability of total ginsenosides in the human body after oral administration is low, and they are eliminated very quickly in the body

Method used

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  • Improved Zhenyuan tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] For every 1000 pieces of improved vibrator chips, the dosage of each component is as follows:

[0030] Element Dosage for 1000 tablets (g) effect Panax ginseng saponins 25 Main drug starch 25 filler Lactose Monohydrate 200M 50 filler Povidone K30 1.0 Adhesive / Slow Release Material silica 1.5 Antisticking agent Magnesium stearate 0.5 lubricant Hydroxypropylmethylcellulose 1.5 Coating material

[0031] The method for making the improved vibration source sheet includes:

[0032] (1) Pass ginseng fruit saponins, starch, 200M lactose monohydrate, silicon dioxide, and magnesium stearate through a 100-mesh sieve for later use.

[0033] (2) Weigh 200 M of total ginseng fruit saponins, starch, and lactose monohydrate in the prescribed quantity, place them in a mixing granulator, and mix them evenly.

[0034] (3) Take the prescribed amount of povidone K30 and add it to 60v% ethanol to dissolve, add the obta...

Embodiment 2

[0041] For every 1000 pieces of improved vibrator chips, the dosage of each component is as follows:

[0042] Element Dosage for 1000 tablets (g) effect Panax ginseng saponins 25 Main drug starch 30 filler Lactose Monohydrate 200M 70 filler Hydroxypropylmethylcellulose 2.0 Adhesive / Slow Release Material silica 2.5 Antisticking agent Magnesium stearate 1.0 lubricant Opadry (stomach-soluble type) 2.5 Coating material

[0043] The method for making the improved vibration source sheet includes:

[0044] (1) Pass ginseng fruit saponins, starch, 200M lactose monohydrate, silicon dioxide, and magnesium stearate through a 100-mesh sieve for later use.

[0045] (2) Weigh 200 M of total ginseng fruit saponins, starch, and lactose monohydrate in the prescribed quantity, place them in a mixing granulator, and mix them evenly.

[0046] (3) Add the prescription amount of hydroxypropyl methylcellulose dispersed in 17ml...

Embodiment 3

[0053] For every 1000 pieces of improved vibrator chips, the dosage of each component is as follows:

[0054] Element Dosage for 1000 tablets (g) effect Panax ginseng saponins 25 Main drug starch 28.5 filler Lactose Monohydrate 200M 60 filler Hydroxypropylmethylcellulose 1.52 Adhesive / Slow Release Material silica 2 Antisticking agent Magnesium stearate 0.5 lubricant Polyvinyl acetal diethylamine acetate 2.01 Coating material

[0055] The method for making the improved vibration source sheet includes:

[0056] (1) Pass ginseng fruit saponins, starch, lactose monohydrate 200M, silicon dioxide, and magnesium stearate through a 100-mesh sieve for later use.

[0057] (2) Weigh 200 M of total ginseng fruit saponins, starch, and lactose monohydrate in the prescribed quantity, place them in a mixing granulator, and mix them evenly.

[0058] (3) Add the prescription amount of hydroxypropyl methylcellulose dispers...

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Abstract

The invention relates to an improved Zhenyuan tablet and a preparation method thereof in the technical field of pharmaceutical preparations. The improved Zhenyuan tablet includes a tablet core and a coating, wherein the tablet core includes ginseng fruit saponins and a sustained-release material, and the coating includes a sustained-release coating material. By adding the sustained-release material in the tablet core and adopting the coating containing the sustained-release coating material, the slow release time of the Zhenyuan tablet is prolonged, and the bioavailability of ginseng fruit saponins in the Zhenyuan tablet is improved. The Zhenyuan tablet has a good slow-release effect. Each 1000 Zhenyuan tablets preferably include the following ingredients: 25 g of ginseng fruit saponins, 28.5 g of starch, 60 g of lactose monohydrate, 1.52 g of povidone, 2 g of silica, 0.5 g of magnesium stearate and 2.01 g of gastric soluble opadry. The povidone is used as both a sustained-release material and a binder to reduce the tablet weight.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an improved vibration source tablet and a preparation method thereof. Background technique [0002] Zhenyuan Tablet has the functions of nourishing and strengthening, prolonging life, anti-fatigue, anti-stress and anti-hypoxia. It can be applied clinically to dizziness, fatigue, premature aging and neurasthenia, endocrine disorders and other indications. It is mainly administered orally. [0003] Zhenyuan tablets generally require a course of treatment in order to achieve the therapeutic effects of improving resistance, regulating yin and yang, and eliminating toxins and adverse factors in the body. For example, to improve aging symptoms and treat senile diseases, according to the clinical observation of 327 cases in authoritative hospitals, after two months of taking it for middle-aged and elderly people, the aging symptoms were significantly improved, and th...

Claims

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Application Information

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IPC IPC(8): A61K9/32A61K9/36A61K9/22A61K36/898A61P9/00A61P9/10A61P25/20A61P39/00A61P39/06
CPCA61K9/2054A61K9/284A61K9/2866A61K36/898A61P9/00A61P9/10A61P25/20A61P39/00A61P39/06
Inventor 管悦琴罗雪峰郑卫兵管习海
Owner HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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